Navigation Links
Living with salt

Over the years, a number of Weizmann Institute scientists have addressed the question of how molecules essential to life, such as proteins, have adapted to function in extreme environments. The proteins they investigated were isolated from halophilic (salt-loving) microorganisms from the Dead Sea. After determining the 3-D structures for several halophilic proteins, researchers were able to explain how these proteins not only cope with high salinities, but are actually "addicted" to them. However, the alga Dunaliella salina is an organism of a different streak: it is able to grow in any salinity, from the extremes of the Dead Sea to nearly fresh water. The uniquely salt-tolerant Dunaliella, which is commercially grown as a source of natural beta carotene, has been investigated at the Weizmann Institute for over 30 years. Yet, the secrets of its exceptionally successful adaptation to salt remained unresolved.

In a recent paper published in the Proceedings of the National Academy of Sciences, USA (PNAS), Institute scientists Prof. Ada Zamir and Dr. Lakshmanane Premkumar of the Institute's Biological Chemistry Department and Prof. Joel Sussman and Dr. Harry Greenblatt of the Structural Biology Department revealed the structural basis of a remarkably salt-tolerant Dunaliella enzyme, a carbonic anhydrase, which may hold the key. Comparisons with known carbon anhydrases from animal sources showed that the Dunaliella enzyme shares a basic plan with its distant relatives, but with a few obvious differences. The most striking of these is in the electrical charges on the proteins' surfaces: Charges on the salt-tolerant enzyme are uniformly negative (though not as intensely negative as those in halophilic proteins), while the surfaces of carbonic anhydrases that don't tolerate salt sport a negative/positive/ neutral mix. This and other unique structural features may enable the algal carbonic anhydrase to be active in the presence of salt, though not dependent on it. In
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2

Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Living anti-HIV gel shows early promise
3. Living taste cells produced outside the body
4. Living laboratory found on shoreline statues
5. Study: Living coral reefs provide better protection from tsunami waves
6. Living view in animals shows how cells decide to make proteins
7. Living with water scarcity -- world must act now
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Living with salt

(Date:4/17/2014)... Our eyes not ... with a continuous stream of information about our own movements. ... a car the world glides by us and leaves ... our brain calculates self-motion from this "optic flow". This way, ... during our own movements. Together with biologists from the University ...
(Date:4/17/2014)... Rajendra Singh Thursday as a "Champion of Change" ... deployment in the residential, commercial and industrial sectors. ... Electrical and Computer Engineering and director of Clemson,s ... hero leading the charge across the country to ... and driving policy changes at the local level ...
(Date:4/17/2014)... a novel method to help kidney stone sufferers ... treatment possible., Kidney stones represent a major medical ... left untreated, apart from being particularly painful, they ... In many patients treated successfully, stone recurrence is ... approach to diagnosis and treatment needs to be ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... shedding light on possible causes of infertility and autoimmune ... and florescent genes to illuminate cells that produce a ... lupus. The technique will help scientists track the ... ensuring supplies of breast milk in nursing mothers but ...
... Belfast academic has shown that crabs not only suffer pain ... study, which looked at the reactions of hermit crabs to ... and Mirjam Appel from the School of Biological Sciences at ... Behaviour . Professor Elwood, who previously carried out a ...
... fish stocking has on aquatic insects in mountain lakes ... to a study completed by U.S. Forest Service and ... a current online issue of the journal Freshwater Biology ... fisheries management practices now in use in California mountain ...
Cached Biology News:Crabs' memory of pain confirmed by Queen's academic 2Study assesses impact of fish stocking on aquatic insects 2
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), ... commercializing innovative therapies addressing major unmet medical needs ... the Notice of Allowance from the United States ... RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. ...
(Date:1/14/2014)... OTTAWA, Ontario , Jan. 14, 2014   Kinaxis ®, ... ( SCM ) and sales and operations planning ( S&OP ... the Biomanufacturing Summit , which will be held at ...  At the conference, join Kinaxis customer Elisabeth Kaszas , ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Globally, approximately 418 million,people are currently infected with ... hepatitis in the 21st century cannot be,understated or ... by Kalorama Information. Paradoxically, despite the obvious ... to contain hepatitis. Yet the incidence and,prevalence of ...
... Tuesday, September 11, 2007 - 11:00 a.m. ET; 8:00 ... 6 /PRNewswire-FirstCall/ - MIGENIX,Inc. (TSX: MGI; OTC: MGIFF), a ... conference call and webcast on Tuesday,September 11, 2007 at ... for the first fiscal quarter ended July 31, 2007. ...
... Inc.,(Nasdaq: VRUS ) and Roche (OTC: RHHBY) ... for the treatment of chronic hepatitis C,virus (HCV) ... on Hepatitis C,Virus and Related Viruses being held ... prodrug of PSI-6130, is an oral cytidine nucleoside,analog ...
Cached Biology Technology:Touching 418 Million Lives, Hepatitis Still Presents Significant Threat to Global Health 2MIGENIX First Fiscal Quarter 2008 Financial Results Conference Call & Webcast Notification 2Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses 2Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses 3Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses 4Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses 5
Mouse monoclonal antibody raised against a partial recombinant ARHGEF11. NCBI Entrez Gene ID = ARHGEF11...
Mouse monoclonal antibody raised against a partial recombinant MYO7A. NCBI Entrez Gene ID = MYO7A...
... PrecisION Ion Channel Cell Lines ,High ... ,Ion channels are well known for having ... function and consequently have a key function ... that modulate ion channels have been investigated ...
... Channel Cell Lines ,High Quality, Functionally-Validated, Ion ... well known for having a critical role ... have a key function in pain, CNS ... channels have been investigated in therapeutic areas, ...
Biology Products: