Navigation Links
Living view in animals shows how cells decide to make proteins

oduces within the cell.

The scissors that do the genetic chopping are, in most cells, proteins called splicing silencers and splicing enhancers.

In the current study, Garcia-Blanco’s team sought to identify which silencers chop out an important segment of RNA in a gene called fibroblast growth receptor 2 (FGFR2). This gene plays a critical role in normal mouse and human development, and the order in which its RNA is assembled can alter an animal’s development.

As a model system to study, the scientists genetically created a "glowing" mouse. The mouse carried in its FGFR2 gene a green fluorescent tag that would glow when a common type of silencer, called an "intronic silencer," chopped out a specific exon, called IIIb.

In this way, the scientists could track whether intronic silencers were chopping out the IIIb exon -- and if so, in which tissues and organs -- or whether other types of silencers or helper proteins were involved.

By tracking the green glow, the team found that cells in most tissues made the same decision to silence exon IIIb, but the cells used a variety of silencers and helper proteins to accomplish this task, said Vivian I. Bonano, a graduate student in the University Program in Genetics and Genomics and lead author of the journal report.

"Identifying which silencers are active in a given tissue or organ will ultimately help scientists understand how exons are erroneously included or excluded in various disease processes," Bonano said.

For example, a cell’s decision to include exon IIIb is critical because the exon’s presence or absence determines which variant of the FGFR2 protein is produced, she said. Such subtle variations in proteins can alter the cell’s behavior, just as switching ingredients in a favorite recipe can change the food’s flavor, according to the scientists.

"Viewing these decisions is most relevant in a living animal, because cells behave different
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Living with salt
3. Living anti-HIV gel shows early promise
4. Living taste cells produced outside the body
5. Living laboratory found on shoreline statues
6. Study: Living coral reefs provide better protection from tsunami waves
7. Living with water scarcity -- world must act now
8. Plants, animals share molecular growth mechanisms
9. Elephants imitate truck noises, other animals
10. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
11. Gene therapy for Parkinsons disease moves forward in animals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Living view animals shows how cells decide make proteins

(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... When a pathogen attacks a plant, infection usually follows ... of researchers at the University of California, Riverside focused on ... of the 19 th century by infecting potato plants, ... system. The genus Phytophthora contains many notorious ...
... As fibers go, there,s never been anything quite like spider silk. ... holds up. It is five times stronger than steel and can ... right back like new. Ounce-for-ounce spider silk is even stronger than ... be understandable to think that science knows all there is to ...
... needs to eat. But it,s a dog-eat-dog world, and with ... To cope with this vicious reality, a tiny insect that ... physical protection from its beetle predator. The pest ... numerous countries in recent years has caused immeasurable loss of ...
Cached Biology News:Scientists identify genetic mechanism that contributed to Irish Famine 2Scientists identify genetic mechanism that contributed to Irish Famine 3Stanford researcher sheds new light on the mysteries of spider silk 2Stanford researcher sheds new light on the mysteries of spider silk 3Stanford researcher sheds new light on the mysteries of spider silk 4Pest uses plant hairs for protection 2
(Date:5/28/2015)... , May 28, 2015 RXi Pharmaceuticals Corporation ... discovering and developing innovative therapeutics, primarily in the areas ... a public offering of 26 million units at a ... gross proceeds of approximately $10.4 million. Each unit consists ... 13-month overallotment purchase right to purchase 0.50 of a ...
(Date:5/28/2015)... 2015  GenVec, Inc. (Nasdaq: GNVC ) today ... Swirsky , will present a company overview at the ... on Thursday, June 4, 2015. The ... be available at the following link:  http://wsw.com/webcast/jeff88/gnvc .  ... To access, visit www.genvec.com , click on "Investors ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 The Fertility ... our own Dr. Danielle Vitiello has taken on a ... role, Dr. Vitiello will provide guidance, leadership, oversight and ... to count Dr. Vitiello among our team of experienced ... and CEO, Joseph A. Hill, M.D. “Her expertise and ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
Breaking Biology Technology:RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3
... and OTTAWA, Nov. 20 Sports and,nutritional product ... http://www.naturalnutritioninc.com announced today that it has,launched an ... Lightning Pain Relief Cream. Made from a combination ... be marketed,on the internet and television. Natural ...
... Spheris to be the First Provider of Clinical Documentation Technology, ... ... Tenn., Nov. 20 Spheris has been selected as,the first ... of the nation,s leading group purchasing organizations.,Under the parties, agreement, ...
... CRY ),a biomaterials, medical device and tissue processing company, ... 19th Annual Piper Jaffray,Health Care Conference at the Pierre ... Steven G. Anderson, president and CEO of CryoLife, ... p.m. EST. CryoLife,s live presentation may be accessed ...
Cached Biology Technology:Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief 2Provista Awards Agreement to Spheris 2CryoLife to Present at 19th Annual Piper Jaffray Health Care Conference in New York 2
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
5-bromouridine 5'-triphosphate (BrUTP) *10 mM in TE buffer*...
...
in vitro Translation, Accessory Products...
Biology Products: