Navigation Links
Living taste cells produced outside the body

onths, were similar to mature taste cells in several key respects. A variety of methods were used to show that the cultured cells contain unique marker proteins characteristic of mature functioning taste receptor cells. In addition, functional assays revealed that the cultured cells responded to either bitter or sweet taste stimuli with increases of intracellular calcium, another property characteristic of mature taste cells.

Lead author Hakan Ozdener, MD, PhD, observes, "Although scientists have tried for many years to maintain taste cells in a long-term culture system, it was commonly believed that these cells could not be kept alive for longer than about 10 days. Now, we have demonstrated that taste cells can be generated in vitro and maintained for a prolonged period of time."

The taste cell culture system provides new insight into how basal cells turn into functional taste cells. Although previous dogma had held that induction was somehow dependent on interactions with the nervous system, the current findings suggest otherwise. Ozdener explains, "By producing new taste cells in an in vitro system, our results demonstrate that direct stimulation from nerves is not necessary to generate taste cells from precursors."

By using the cultured taste cells, researchers now have more precise control over the cell's surrounding environment, as well as better access to subcellular mechanisms, allowing them to ask certain questions that could not previously be addressed.

For instance, cultured cells can be used to study how taste stimuli interact to enhance good tastes or suppress unpleasant tastes. Similarly, new molecules, including potential artificial sweeteners or bitter blockers, can be evaluated to see if they interact with taste receptors to activate the cell.

Another important avenue for research aims to help people who have lost their sense of taste from radiation or diseases. Identification of factors that promote tast
'"/>

Source:Monell Chemical Senses Center


Page: 1 2 3

Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Living with salt
3. Living anti-HIV gel shows early promise
4. Living laboratory found on shoreline statues
5. Study: Living coral reefs provide better protection from tsunami waves
6. Living view in animals shows how cells decide to make proteins
7. Living with water scarcity -- world must act now
8. Childrens taste sensitivity and food choices influenced by taste gene
9. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
10. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
11. Bitter or sweet? The same taste bud can tell the difference
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Living taste cells produced outside the body

(Date:8/19/2014)... Some infants born with neonatal abstinence syndrome ... more difficult time going through withdrawal than others, ... While genetic and epigenetic (when genes are turned ... as potential factors, researchers at Boston University School ... conducted a first of its kind study to ...
(Date:8/19/2014)... students in college biology and other science courses ... quantitative ways, and now they have a new ... the Life Sciences," published this month by Princeton ... Institute for Mathematical and Biological Synthesis (NIMBioS), teaches ... can be used to explore and explain biological ...
(Date:8/19/2014)... of UTSA researchers has been awarded a nearly $40,000 ... Training (NCPTT), an office of the National Park Service ... will fund a one-year study of the energy efficiency ... homes in hot, humid climates. , Radiant barriers are ... that reflect heat back, thereby reducing the amount of ...
Breaking Biology News(10 mins):In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3
... certain disease mechanisms, illness progression and response to new ... such as nematodes, fruit flies or zebra fish. ... of many individual animals to detect mutants worthy of ... system that uses artificial intelligence and cutting-edge image processing ...
... scientists at the University of California, Berkeley, provide a clearer ... change, and where they go. One study, published ... Biology , finds that changes in precipitation have been underappreciated ... normal range. In the other study, published today (Wednesday, Aug. ...
... Mich. --- Two new species of owls have been discovered ... a key role in confirming their existence. The ... Forktail, the Journal of Asian Ornithology , took years to ... paper,s lead author Pam Rasmussen, MSU assistant professor of zoology ...
Cached Biology News:Artificial intelligence helps detect subtle differences in mutant worms 2Artificial intelligence helps detect subtle differences in mutant worms 3Artificial intelligence helps detect subtle differences in mutant worms 4Studies shed light on why species stay or go in response to climate change 2Studies shed light on why species stay or go in response to climate change 3Studies shed light on why species stay or go in response to climate change 42 new owls discovered in the Philippines 2
(Date:8/20/2014)... , Aug. 20, 2014 /PRNewswire-iReach/ -- A ... transformative collaboration between the school,s bioengineering department and ... of the Intel® Software Academic Program, UCSD,s research ... and the human body.  Photo ... study exhibits the work of Dr. Todd ...
(Date:8/20/2014)... 2014 GraphDB™ 6.0 ... improvements to the enterprise replication cluster, faster loading ... SOLR and Elasticsearch. This release happens to coincide ... triplestore – GraphDB™ was formerly known as OWLIM. ... only mature enterprise resilient RDF triplestore will also ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the ... report to their offering. This report analyzes the ... by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , Europe ... America . Annual estimates and forecasts are provided for the ...
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 Research ... Oxide Fuel Cells (SOFCs) - Global Strategic Business Report" ... the worldwide markets for Solid Oxide Fuel Cells (SOFCs) in ... US, Canada , Europe ... Annual estimates and forecasts are provided for the period 2012 ...
Breaking Biology Technology:Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2
... game of inches," but biology is a game of nanometers, ... the fate of a cell - whether it lives or ... Department of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) ... impact of spatial patterns on living cells. Chemist Jay ...
... GAITHERSBURG, Maryland, November 2, 2011 - ... -based HPV Testing Increases Screening Coverage and is More Sensitive ... in the Lancet Promising findings published today ... community-based, randomized equivalence trial undertaken by public health authorities in ...
... Epitomics, Inc., a California based biotech company, announced ... Allowance from the United States Patent and Trademark ... Proteins (application 10/705,109).  The Notice allowed 17 claims ... samples using libraries of antibodies.  This method has ...
Cached Biology Technology:Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells 2Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells 3Home-based Self-collected Vaginal Specimens Detect More Cervical Lesions and Cancers Than Cytology 2Home-based Self-collected Vaginal Specimens Detect More Cervical Lesions and Cancers Than Cytology 3Home-based Self-collected Vaginal Specimens Detect More Cervical Lesions and Cancers Than Cytology 4Home-based Self-collected Vaginal Specimens Detect More Cervical Lesions and Cancers Than Cytology 5