Navigation Links
Liver regeneration may be simpler than previously thought

assumed for other organs. New processes may explain why the liver is so uniquely capable of renewal and repair after injury, the scientists thought.

Karp's team considered two samples of mice. The first consisted of embryonic mice at various stages of development while the second was composed of adult mice to which two-thirds of their liver were removed. Using techniques such as DNA microarrays ?which determine which genes are active in a cells ?and software programs that analyze the collected information, the scientists listed all the proteins that help the cells grow and proliferate in both samples.

The results were unexpected. The researchers noticed that only a few proteins were common to both processes. Proteins called transcription factors, which affect DNA in the cell's nucleus, were highly involved in the development of embryos' livers but not in adult liver regeneration. Instead, proteins that help cells proliferate were active in both the developing and regenerating livers.

These findings showed that a regenerating liver does not behave as a developing embryo. Instead, regeneration could actually be only due to an increase in cells that multiply through regular cell divisions, a process called hyperplasia.

The new results may also have important medical implications. Transcription factors are known to be more difficult to manipulate than the other identified proteins. Since the transcription factors were not present in regenerating livers, it might be easier to stimulate liver regeneration by only activating the other identified proteins.

"These results are very encouraging," Karp says. "Not only did we discover that the number of proteins involved in liver regeneration is relatively low, but they don't include transcription factors, so we may be closer to being able to stimulate liver regeneration than we thought."

The next step will be for scientists to understand whether the regenerating
'"/>

Source:American Society for Biochemistry and Molecular Biology


Page: 1 2 3

Related biology news :

1. Research Gives Hope For Liver Damage
2. Gene Therapy Cures Inherited Liver Disease In Rats
3. Liver cancer linked to cellular repair pathway
4. New component of the brakes on nerve regeneration found
5. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
6. Tissue regeneration operates differently than expected
7. New understanding of regeneration gained by Forsyth scientists
8. Protein-coated dental implants could improve bone regeneration
9. Rescuing injured hearts by enhancing regeneration
10. Key to zebrafish heart regeneration uncovered
11. Research project tackles regeneration gap
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Liver regeneration may simpler than previously thought

(Date:5/21/2013)... Chicago College of Medicine will study gender differences in how ... source -- and how changes in fat metabolism play a ... grant from the National Heart, Lung and Blood Institute. , ... energy. These changes may play a major role in the ... women, says E. Douglas Lewandowski, director of the UIC Center ...
(Date:5/21/2013)... of insulin action in cells in precise detail like ... what goes wrong in diabetes. , The breakthrough ... from Sydney,s Garvan Institute of Medical Research, is now ... journal Cell Metabolism . , First discovered in ... in the body because it helps us lower blood ...
(Date:5/20/2013)... about the effect of physical education (PE) on child ... that increasing the amount of time that elementary schoolchildren ... , The study represents some of the first evidence ... and is forthcoming in the Journal of Health ... study can be viewed at: http://www.sciencedirect.com/science/article/pii/S0167629613000556 , ...
Breaking Biology News(10 mins):Do men's and women's hearts burn fuel differently? 2Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3Gym class reduces probability of obesity, study finds for first time 2
... time impact the delivery of drugs and explain a ... nanoparticles that can penetrate a cell without poking a ... The key to their approach? Stripes. The team ... two different kinds of molecules can quickly pass into ...
... Spanish . Networks for radiological monitoring ... environment and detect possible incidents. The PhD thesis ... the University of the Basque Country provides a ... radiological incidents caused externally. Most countries ...
... independent review of social and ethical challenges associated with ... published today (9 June). The report, commissioned by the ... Society Strategy Panel, is part of its programme to ... rapidly emerging area of science and technology. Embargoed copies ...
Cached Biology News:MIT: Stripes key to nanoparticle drug delivery 2More sensitive radiology monitoring in the Basque Country 2More sensitive radiology monitoring in the Basque Country 3Synthetic Biology: funders move to address social and ethical challenges 2
(Date:5/21/2013)... The congress of the ERA-EDTA (European Renal Association ... congress in Europe on nephrology ... Istanbul to share their knowledge ... have been presented: / (1) Gupta, A ... REDUCES ESA USE" By SFP-iron administration, the ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 ... services company for clinical trials, announced today it ... Solutions, LLC. Clinverse’s ClinPay® FLS eClinical commerce ... payment process. SpendMD ™, Aggregate Spend ... solution for tracking and reporting transfer of value ...
(Date:5/21/2013)... New York , May 21, 2013 ... by Transparency Market Research ( http://www.transparencymarketresearch.com ) "Biochip Products ... Research, IVD Tests) - U.S. Industry Analysis, Size, Share, Growth, ... 2.4 billion in 2011 and is expected to grow ... to reach an estimated value of USD 4.7 billion ...
(Date:5/21/2013)... 2013 Many have long discussed the ... acne. Recently physicians from Clinical Psychiatry.com readdressed ... the skin, and suggested using hypnotherapy and ... produced from stress that cause acne. , Doctors in ... acne brings about, stress causes changes in the skin ...
Breaking Biology Technology:ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5Adult Acne Treatment, Probiotic Action Explains How Hypnotherapy and Probiotics May Cure Various Skin Conditions 2
... Better Understanding ... 15 Results from the Global Longitudinal,study of Osteoporosis in ... do not believe they are at a higher risk of,fractures ... than,60,000 women over age 55 and was presented today at ...
... September 15 , - Oncentra(R) RT Viewer* ... September 14-18 and ASTRO 2008, Boston, USA, September,21-24, ... today,announced the market release of Oncentra RT Viewer. ... allows clinicians to review,radiotherapy plans that are generated ...
... 12 Fougera, a division of Nycomed,US Inc., ... Cream USP,1%. The generic formulation compares to Taro,s ... sizes: 15g tubes (NDC # 0168-0133-15), 30g tubes,(NDC ... "The approval of Clotrimazole Cream is another ...
Cached Biology Technology:Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures 2Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures 3Nucletron Announces Market Release of First Commercially Available Software to Review and Share Dicom-Based Treatment Plans for Radiotherapy 2
Monoclonal mouse antibody for immunihistology, clone AD12, Isotype IgG 1, purified, specific for rat pyruvatekinase type L, no cross-reactivities with other pyruvate kinase isoenzymes have been obser...
Control primers and template for 5kb and 15 kb products....
The Lambda Control Kit contains lambda DNA and two 25mer primers, which can be used to amplify a 500bp fragment. The lambda DNA is purified by CsCl gradient centrifugation and organic extraction foll...
... Klein Taq is a derivative of Taq ... truncated Thermus aquaticus DNA polymerase. Expressed from ... initiates at Met236, bypassing the 5'-3' exonuclease ... enzyme reveals a highly active and even ...
Biology Products: