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Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

rmed statistical analysis to assess which factors might have influenced patient outcomes.

The median survival of all patients was 6.83 months. Patients with high pre-treatment HBV DNA had a significantly higher incidence of developing severe hepatitis during chemotherapy and had poorer survival. Other factors significantly affecting survival were high total bilirubin and HCV infection.

“The present study has shown that a pre-chemotherapy viral load higher than 10(5.65) copies per milliliter is associated with poorer survival in HCC patients with chronic HBV infection, and this association is independent of an individual’s hepatic reserve, tumor and clinical factors,” the authors report.

Though the study was limited by a small patient cohort, and the fact that all had advanced disease, the authors concluded, “Based on the present findings, the incorporation of anti-viral therapies to reduce HBV viral load should be considered as part of management for HCC patients undergoing chemotherapy.”


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Source:John Wiley & Sons, Inc.


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