Navigation Links
Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

In the June issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD), researchers report their findings from the first-ever study examining the prognostic value of serum HBV DNA levels for patients with liver cancer undergoing chemotherapy. They found that patients with high pre-chemotherapy levels of HBV DNA had a significantly increased incidence of severe hepatitis which was associated with the worst survival. The article is also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology).

HBV is associated with a more than 200-fold increase in risk of liver cancer. In areas where HBV is endemic, like China and the Far East, the great majority of cases of hepatocellular carcinoma (HCC) occur in individuals with the virus. For most patients whose cancer is inoperable, chemotherapy is one of the main treatment options, and still the prognosis is dismal. Survival is often measured in months.

Researchers, led by Winnie Yeo of the Chinese University of Hong Kong, examined the significance of pre-chemotherapy HBV DNA levels in the blood on the survival of HCC patients. They studied 188 patients participating in a phase III randomized controlled trial comparing two different chemotherapy regimens. One hundred and seventy patients (92 percent) had evidence of HBV infection. Of these, 125 had sera available to determine HBV DNA levels and were included in the study.

For each patient, the researchers measured the level of HBV DNA in the blood before the start of chemotherapy. They also gathered other potentially important prognostic information, like age, sex, total bilirubin and presence of cirrhosis. Over the course of each patient’s treatment, the researchers monitored blood counts, renal and liver function and clinical signs and symptoms. They then perfo rmed statistical analysis to assess which factors might have influenced patient outcomes.

The median survival of all patients was 6.83 months. Patients with high pre-treatment HBV DNA had a significantly higher incidence of developing severe hepatitis during chemotherapy and had poorer survival. Other factors significantly affecting survival were high total bilirubin and HCV infection.

“The present study has shown that a pre-chemotherapy viral load higher than 10(5.65) copies per milliliter is associated with poorer survival in HCC patients with chronic HBV infection, and this association is independent of an individual’s hepatic reserve, tumor and clinical factors,” the authors report.

Though the study was limited by a small patient cohort, and the fact that all had advanced disease, the authors concluded, “Based on the present findings, the incorporation of anti-viral therapies to reduce HBV viral load should be considered as part of management for HCC patients undergoing chemotherapy.”


'"/>

Source:John Wiley & Sons, Inc.


Related biology news :

1. Research Gives Hope For Liver Damage
2. Gene Therapy Cures Inherited Liver Disease In Rats
3. Liver cancer linked to cellular repair pathway
4. Liver regeneration may be simpler than previously thought
5. Viral DNA sequence a possible trigger for breast cancer
6. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
7. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
8. Columbia research lifts major hurdle to gene therapy for cancer
9. Combination therapy boosts effectiveness of telomere-directed cancer cell death
10. Mitochondrial DNA mutations play significant role in prostate cancer
11. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance ... consulting, provides a free webinar on Performing Quality Investigations: Getting to ... 12pm CT at no charge. , Incomplete investigations are still a major concern ...
(Date:6/22/2016)... , June 22, 2016 Cell Applications, ... allow them to produce up to one billion ... lot within one week. These high-quality, consistent stem ... preparing cells and spend more time doing meaningful, ... a proprietary, high-volume manufacturing process that produces affordable, ...
Breaking Biology Technology: