Navigation Links
Linking DNA and histone methylation

In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.

Dr. Carey emphasizes that "The study provides a new direction to understand how histone and DNA methylation, two phenomena that play a significant role in stem cell differentiation and cancer, can communicate with each other to turn genes off. "

Although both histone and DNA methylation have long been recognized as hallmarks of euchromatic gene silencing, how these two processes cooperate to induce silencing has remained unresolved. In their upcoming paper, Dr. Carey and colleagues detail that mammalian HP1 proteins facilitate this cooperation.

They found that HP1 proteins, which bind to methylated histones, also interact with the DNA methyltransferase, DNMT1, to stimulate its DNA methylation activity. DNMT1, in turn, reinforced HP1 binding to methylated histones. Finally, the researchers showed that DNMT1-stimulated HP1 binding is required for gene silencing.
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Autism gene identified by researchers at Yale working with a global research consortium
2. Columbia research lifts major hurdle to gene therapy for cancer
3. U of M researcher examines newly emerging deadly disease
4. NYU researchers simulate molecular biological clock
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. New research questions basic tenet of neuron function
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
11. New protein discovered by Hebrew University researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Research and Markets has announced the addition of the ... offering. The report forecasts the ... at a CAGR of 12.28% during the period 2016-2020. ... analysis with inputs from industry experts. The report covers the market ... also includes a discussion of the key vendors operating in this ...
(Date:6/22/2016)... , June 22, 2016  The American College of Medical ... Show Executive Magazine as one of the fastest-growing trade ... 25-27 at the Bellagio in Las Vegas ... highest percentage of growth in each of the following categories: ... companies and number of attendees. The 2015 ACMG Annual Meeting ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... to bring innovative medical technologies, services and solutions to the healthcare market. The ... implementation of various distribution, manufacturing, sales and marketing strategies that are necessary to ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
Breaking Biology Technology: