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Link found between immune system and high plasma lipid levels

cells expressing LIGHT were introduced into the mice, lipid levels rose, both when the mice were fed a regular diet, and also when fed a high-fat, high-cholesterol diet. However, if researchers blocked the LIGHT signaling, using an engineered protein (LTbR-Ig), lipid levels were lowered again.

Two organs believed to regulate lipid levels are the liver and the intestine. Researchers looked at the mouse livers ?particularly at the enzyme, hepatic lipase. This enzyme is made in the liver and secreted into the blood where it plays a key role in lipid metabolism. The livers of mice with T cells expressing LIGHT made and secreted much less hepatic lipase ?and consequently, had higher plasma lipid levels.

The authors write: "Our data may help to explain the long time dogma that chronic inflammation is associated with hyperlipidemia, the mechanisms of which have not been well defined. Whether this is an intended and advantageous product of inflammation or untoward consequences of combating pathogens or autoimmunity remains to be determined."


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Source:University of Chicago Medical Center


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