Navigation Links
Linheng Li Lab documents the development of cancer stem cells

Xi He, M.D., Research Specialist II, and Linheng Li, Ph.D., Associate Investigator, are the first and last authors, respectively, on a new publication that clarifies how normal stem cells become cancer stem cells and how cancer stem cells can cause the formation of tumors.

The paper, "PTEN-deficient intestinal stem cells initiate intestinal polyposis" was posted to the Nature Genetics Web site on January 21.

The theory that cancer stem cells initiate and drive cancer cell growth has been gaining popularity in both clinical and basic research. Recent studies have identified cancer stem cells and shown that they may cause tumors when transplanted into a secondary host. Until now, however, little was known about the process by which mutations in a stem cell result in primary tumor initiation.

The Li Lab team studied the intestinal system in mice in which one of the human tumor suppressor genes, PTEN, had been deleted. They found that the PTEN/Akt pathway likely regulates stem cell activation by helping control nuclear localization of beta-catenin, the Wnt pathway effector, through phosphorylation of beta-catenin -- including Serine552.

"We found that a loss of PTEN in intestinal epithelial cells accompanied by a loss of PTEN in stromal cells can lead to changes that may increase the number of stem cells and change their position or location," said Dr. Li. "These changes result in crypt fission and budding and can lead to intestinal polyposis and uncontrolled tumor growth."

"All of us were very excited to be part of these efforts to reveal basic features of cancer stem cells," said Dr. He. "What we learned -- that cancer stem cells are a rare population in the tumor mass; that they are slow cycling but more active than normal stem cells; and that cancer stem cells and stromal insertions initiate the process of primary tumorigenesis -- will be influential in our future work."

"Findings from the Li Lab create
'"/>

Source:Stowers Institute for Medical Research


Page: 1 2

Related biology news :

1. Novel experiment documents evolution of genome in near-real time
2. A much-needed shot in the arm for HIV vaccine development
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. Zebrafish may hold key to understanding human nerve cell development
5. Scientists identify new model Of NK cell development
6. Influenza vaccine uses insect cells to speed development
7. Chemists identify key gene in development of type 1 diabetes
8. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
9. Liposome finding implies electrical effect on cell development
10. Multi-purpose protein regulates new protein synthesis and immune cell development
11. Gene keeps neural cells on correct developmental path
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Linheng Lab documents the development cancer stem cells

(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
(Date:12/10/2014)... Dec. 8, 2014 You,ve been here before: you ... can,t remember your password, site key or the answer to ... first grade teacher? Today, Hoyos Labs ... app that will finally put an end to the frustration ... TM . 1U leverages a user,s smartphone to acquire ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... Bristol is developing a revolutionary new test to detect breast ... be effective for women of all ages; given that breast ... of 35-55 in Europe, the test could have a dramatic ... The test, which utilises an innovative radar system, will enable ...
... ago, as the last ice age was beginning to wane, often ... in a new study led by University of Washington researchers, an ... dipstick to show that a key section of the West Antarctic ... thought it did. That means it couldn't have contributed as much ...
... University of,Jerusalem have succeeded in discovering and isolating ... structural and qualitative,characteristics that could have consequences for ... cells.,In addition to being obtained from plant tissue, ... quantities as a recombinant protein in,bacteria, making it ...
Cached Biology News:New Breast Cancer Test Could Save Lives 2Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed 2Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed 3The death of a very special chimpanzee 2
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
(Date:12/22/2014)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, announced today the publication ... in conjunction with co-authors from Kyoto University and the ... ongoing clinical research using dermal sheath cup (DSC) cells ... The paper entitled " Hair Follicle Dermal Stem Cells ...
(Date:12/22/2014)... SAN DIEGO , Dec. 22, 2014 ... that the Decipher Prostate Cancer Classifier, a genomic test ... disease in node-negative, high-risk men managed by radical prostatectomy ... with radical prostatectomy is relatively uncommon, using tumor genomics ... form of metastatic disease is an important advance. The ...
(Date:12/22/2014)... The American Journal of ... research, reviews and editorials addressing developments and pathways ... published a provocative article exploring the role of ... potential treatment of prostate cancer. , The ... the possibility that there could be a connection ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... 20, 2011 , Daval International ... randomised, placebo-controlled, double blind Phase II,Study, Treating Patients ... Sclerosis (SPMS). Standard clinical,measures and assessment scores recorded ... biomarkers will be used to investigate safety,efficacy and ...
... WAYNE, Pa. and PETACH TIKVA, Israel, July 20, 2011 ... developing Detect-Ready® tests designed to increase the speed and ... diagnostics distributor Eldan, a part on the Neopharm Group, ... agreement for distribution of MDI,s Detect-Ready MRSA Panel in ...
... Institute have developed a new method to harvest energy ... creation of self-powered microsensors for more accurate and cost-efficient ... the researchers investigated how the flow of water over ... amounts of electricity. The research team demonstrated the creation ...
Cached Biology Technology:Daval International Announces Completion of Phase II Trial for the Treatment of Bladder Dysfunction With AIMSPRO® in Secondary Progressive Multiple Sclerosis 2Daval International Announces Completion of Phase II Trial for the Treatment of Bladder Dysfunction With AIMSPRO® in Secondary Progressive Multiple Sclerosis 3Molecular Detection Inc. and Eldan Electronic Instruments Announce Distribution Agreement for Detect-Ready® MRSA Panel in Israel 2Molecular Detection Inc. and Eldan Electronic Instruments Announce Distribution Agreement for Detect-Ready® MRSA Panel in Israel 3Molecular Detection Inc. and Eldan Electronic Instruments Announce Distribution Agreement for Detect-Ready® MRSA Panel in Israel 4New graphene discovery boosts oil exploration efforts, could enable self-powered microsensors 2New graphene discovery boosts oil exploration efforts, could enable self-powered microsensors 3
Salmonella typhimurium Immunogen: Heat inactivated bacterial cells of Salmonella typhimurium B Storage: 4 C...
...
...
... Clone/PAD: ZMD.366. Immunogen: ... internal region of human SENP1. ... human ~73 kDa SENP1. ... or DYKDDDDK)-HA-tagged-SENP1 transfected Hep2 cell ...
Biology Products: