Navigation Links
Limiting the damage in stroke

hich activates NF-kB, can be controlled. The researchers are able to shut down the molecule at any time in neurons. "More common methods of shutting down a gene remove it from all tissues, for an animal's entire life," Pasparakis says. "You can't do that with NF-kB itself ?in other types of cells the signal has important functions which are necessary for the animal to survive. So to test our hypotheses about its role in neurons, we needed more precise control of the gene." In parallel, Bernd Baumann and Thomas Wirth at the University of Ulm had generated two additional mouse models, which allow the reversible repression or activation of IKK2 at any time in neurons.

"The unique advantage of this system is that we can specifically induce or block this signaling pathway at virtually any time and selectively in neurons," Wirth emphasizes. Putting all of this expertise together permitted the researchers to get a clear picture of IKK2's role after a stroke.

Mice with the hyperactive form of IKK2 in neurons and too much NF-kB signalling, they discovered, suffer even more damage than normal; far more cells die. But if the IKK2 signal is blocked, damaged cells stay alive and even seem to recover. The effects are long-term; neurons in the damaged tissues were still alive several days after the stroke.

Two factors make the study promising in the search for treatments for this deadly disease. First, shutting down the IKK2 signal had beneficial effects even when it was done a few hours after the stroke. That is important when thinking about possible human therapies; it usually takes time for a patient to reach the hospital. Secondly, the same effects could be achieved by blocking IKK2 activity with a small artificial molecule. That's what a drug will have to do. Human cells have a very similar NF-kB signaling network, which means that there is a good chance IKK2 will do something similar in our own brain cells. As NF-kB passes a variety of other importa
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2 3

Related biology news :

1. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
2. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
3. PET/MRI scans may help unravel mechanisms of prenatal drug damage
4. Genetic therapy reverses nervous system damage in animal model of inherited human disease
5. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
6. Purdue scientists may have found key to halting spinal cord damage
7. Logging changed ecological balance for monkeys, damaged health
8. New study finds how cells with damaged DNA alert the immune system
9. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
10. OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis
11. Smoking damages key regulatory enzyme in the lung
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Limiting the damage stroke

(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
(Date:7/10/2014)... , July 3, 2014 Research and ... of the "Global Gesture Recognition & Touch-Less ... Forecasts to 2020" report to their offering ... Global Gesture Recognition & Touch-Less Sensing Market to ... for a while, but the companies were unable ...
(Date:7/10/2014)... , July 9, 2014 The widespread ... in large part by meaningful use and related ... providers interact with laboratory information. Now, more than ... field of clinical informatics in order to deliver ... To address the educational needs of pathologists in ...
Breaking Biology News(10 mins):Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4
... of Sheffield have applied an evolutionary ,use it or ... show that marriage can influence the evolution of age-patterns ... and Dr Andrew Russell, from the University,s Department of ... the 18th and 19th centuries, a time during which ...
... Using satellite data, scientists have produced a first-of-its kind map ... are other local- and regional-scale forest canopy maps, the new ... on one uniform method. The map, based on data ... scientists build an inventory of how much carbon the world,s ...
... University of California, Riverside biologists working on guppies ... long-term studies report that rapid growth responses to ... early in life have repercussions in adulthood. Based ... that grew rapidly as juveniles produced fewer offspring than ...
Cached Biology News:Marriage patterns drive fertility decline 2First-of-its-kind map details the height of the globe's forests 2Rapid growth in adolescence leads to fewer offspring, UC Riverside biologists find 2Rapid growth in adolescence leads to fewer offspring, UC Riverside biologists find 3
(Date:7/10/2014)... today in the journal PNAS (Proceedings of the ... of day and sleep deprivation have a significant effect ... looking at the best time of day to test ... for administering medicines effectively. , Researchers from the University ... investigated the links between sleep deprivation, body clock disruption ...
(Date:7/10/2014)... and spiders can sit upside down forever. Nanophysics makes sure ... in an article just published in Physical Review E ... Geckos and spiders that seem to be able to sit ... worldwide for many years. We will soon be able to ... the gecko,s foot. But the fact is, sooner or later ...
(Date:1/15/2014)... assembling a club sandwich at the nanoscale, National ... succeeded in crafting a uniform, multi-walled carbon-nanotube-based coating ... used in upholstered furniture and other soft furnishings. ... was reduced 35 percent compared with untreated foam. ...
(Date:1/15/2014)... Jan. 15, 2014   Niagara Thermal Products is ... Buffalo BioBlower Technologies LLC ("B3") as the critical thermal ... award from the Army Corps of Engineers.  B3 has ... all biological contaminants and destroys VOCs and other chemical ...
Breaking Biology Technology:Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... a leading waste-to-biofuels company, today held a groundbreaking ceremony ... waste-to-biofuels facility with its partners, the City of Edmonton ... Edmonton Mayor Stephen Mandel and Enerkem Chief Executive Officer ... advanced biofuels plant, which will be located in Edmonton, ...
... - Medicago Inc. (TSX: MDG), a clinical-stage biotechnology ... vaccines based on proprietary manufacturing technologies and Virus-Like ... in a report of President Obama,s Council of ... the President on Reengineering the Influenza Vaccine Production ...
... 31 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ... M. Eastland as Chief Financial Officer and Vice ... Eastland,s responsibilities will include financial management, investor relations ... more than 25 years of financial management experience ...
Cached Biology Technology:Enerkem Announces Construction Start of World's First Municipal Waste-to-Biofuels Facility in Edmonton, Alberta 2Enerkem Announces Construction Start of World's First Municipal Waste-to-Biofuels Facility in Edmonton, Alberta 3Medicago named in Presidential report on meeting the challenges of pandemic influenza 2Medicago named in Presidential report on meeting the challenges of pandemic influenza 3Medicago named in Presidential report on meeting the challenges of pandemic influenza 4ONCOTHYREON APPOINTS JULIE M. EASTLAND AS CHIEF FINANCIAL OFFICER 2
... The steadylite plus assay system ... assay sensitivity, Designed for batch-processing ... for higher density microplates such ... Odor free, Convenient storage conditions ...
... The versatile Promega Flipper® Racks are ... of your small tubes. These polypropylene racks ... choice for freezer storage. They may also ... Each rack is two-sided; one side accommodates ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
...
Biology Products: