Navigation Links
Limiting the damage in stroke

Scientists at the Universities of Heidelberg and Ulm and a unit of the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have discovered that a specific signal within brain cells may determine whether they live or die after a stroke. Their study, published online (November 13) by Nature Medicine, strongly suggests that new therapies for victims of strokes could be developed by controlling a molecule involved in passing the signal.

Strokes lead to death or permanent disabilities for millions of people every year when an interruption of the flow of blood to brain cells deprives them of vital oxygen and nutrients. But the fate of the cells seems to depend on what happens next. Scientists discovered that damaged and dying brain cells are very actively using an internal "communications network" known as the NF-kB signalling pathway. Cells have many such networks; their function is usually to switch genes on or off, changing the chemistry and behavior of the cell. Most drugs work by interfering with molecules that play important roles within these networks.

Scientists knew that NF-kB signaling was active in neurons, but its function was unclear. "We had some evidence that in nerve cells, it could trigger a self-destruction program called apoptosis," says Markus Schwaninger of the University of Heidelberg, one of the heads of the project. "If that was the case, the signal could certainly be playing a role in the death of neurons after stroke and other types of brain damage." To address this hypothesis, Schwaninger's group had established a sophisticated method of creating a stroke-like condition in mice, a model that can be used to investigate new therapies.

What would happen if the activity of NF-kB in neurons were blocked after a stroke? To test this, genetic mouse models were required. The group of Manolis Pasparakis at EMBL's Mouse Biology Unit developed a strain of "conditional knockout" mouse in which a protein called IKK2, w
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2 3

Related biology news :

1. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
2. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
3. PET/MRI scans may help unravel mechanisms of prenatal drug damage
4. Genetic therapy reverses nervous system damage in animal model of inherited human disease
5. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
6. Purdue scientists may have found key to halting spinal cord damage
7. Logging changed ecological balance for monkeys, damaged health
8. New study finds how cells with damaged DNA alert the immune system
9. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
10. OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis
11. Smoking damages key regulatory enzyme in the lung
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Limiting the damage stroke

(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... of Southern California have taken an important first ... therapy. Huntington Disease is an incurable neurological ... loss of intellectual faculties. It affects about 30,000 ... parents with the disease have a 50 percent ...
... posted a status update on the social networking Web ... Just 23 characters long, his message, "using EEG to ... "locked-in" patients can couple brain-computer interface technologies with modern ... doctoral student, Wilson is among a growing group of ...
... Mair of Virginia Beach, a graduate student in ... the first-ever Rachel Carson Award for Scientific Excellence ... is a biologist at the agency,s White Sulphur ... service employees who demonstrate superior scientific involvement and ...
Cached Biology News:New hope for treatment of neurodegenerative disorder 2New hope for treatment of neurodegenerative disorder 3Researchers use brain interface to post to Twitter 2Researchers use brain interface to post to Twitter 3
(Date:5/5/2015)... Research and Markets ( ... the "Separation Systems Market in Biotechnology" ... Macromolecules which include protein, RNA, DNA and ... into smaller molecules, during production of commercially ... advanced systems like centrifugation, liquid chromatography, electrophoresis, ...
(Date:5/5/2015)... LOS ANGELES , May 5, 2015 ... and pioneer in providing on-demand access to scientific, technical ... purchasing agreement with the Association of Southeastern Research ... of 38 research libraries located across 11 southeastern states. ... developing innovative and collaborative programs to address the continually ...
(Date:5/5/2015)... DUBLIN , May 05, 2015 Research ... announced the addition of the "Clinical Laboratory, ... and Forecast 2015 to 2019 - Global Version" ... technical developments especially in the area of molecular ... dynamic, growing and evolving world market that is ...
(Date:5/5/2015)... Hills, MI (PRWEB) May 05, 2015 ... premier Parker Hannifin distributor, announces the launch of ... provide fleet operators with a convenient way to ... maintenance products . , The new ... to 100,000 vehicles with direct access to high ...
Breaking Biology Technology:Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2Exotic Automation & Supply Launches Ecommerce Website 2
... FRANCISCO, March 7, 2012  More than 1,100 leaders from ... Francisco for the two-day conference CALBIO2012: Driven by Patients ... patient access to new treatments through partnering and collaborative ... BIOCOM are organizing a statewide meeting for California,s life ...
... Palatin Technologies, Inc. (NYSE Amex: PTN ) ... ROTH OC Growth Stock Conference on Tuesday, March 13, 2012, ... at the Ritz Carlton Laguna Niguel in Dana Point, CA. ... Officer of Palatin Technologies, will provide an update on Palatin,s ...
...  Synthetic Biologics, Inc.  (NYSE Amex: SYN ), ... medicines for serious illnesses, announced today that Jeff Riley, ... ROTH Capital Partners 24th Annual Growth Stock Conference. The ... Ritz Carlton in Dana Point, CA. Mr. Riley will ...
Cached Biology Technology:First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Synthetic Biologics to Present at ROTH Annual Growth Stock Conference 2
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
MAGP-2 (C-19)...
Laminin gamma-2 (G-16)...
Biology Products: