Navigation Links
Light therapy may combat fungal infections, new evidence suggests

A newly discovered mechanism by which an infectious fungus perceives light also plays an important role in its virulence, according to Howard Hughes Medical Institute investigators at Duke University Medical Center. The findings suggest that changes in light following fungal invasion of the human body may be an important and previously overlooked cue that sparks infection, the researchers said.

The discovery in the human pathogen Cryptococcus neoformans further suggests that light therapy, in combination with anti-fungal drug treatments, might offer an effective method to combat a variety of fungal infections, particularly those of the skin or nails, said HHMI investigator Joseph Heitman, M.D., James B. Duke professor of molecular genetics and microbiology and medicine at Duke.

Light therapy is now used for medical conditions, such as seasonal affective disorder. The most common method, called bright-light therapy, requires that patients sit near a special light box fitted with high-intensity, full-spectrum or white light bulbs. UV irradiation is also used to repigment skin affected by the autoimmune disorder vitiligo.

The findings also have important implications for understanding early fungal evolution, Heitman and study lead author Alexander Idnurm, Ph.D., reported in a forthcoming issue of Public Library of Science Biology, published online March 15, 2005. The National Institute for Allergy and Infectious Diseases and the Burroughs Wellcome Fund supported the research.

The potentially life-threatening fungus C. neoformans invades the central nervous system to cause disease, most commonly in patients who lack a functioning immune system, such as organ transplant recipients, those with HIV/AIDS, and patients treated with steroids or cancer chemotherapy. The fungus' global importance as a health threat has therefore risen in parallel with the increase in immunosuppressive therapies and the worldwide HIV/AIDS epidemic.

Light no
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Light activated anticancer drug targeted to DNA using cisplatin like sub-units
2. New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice
3. Light guides flight of migratory birds
4. Light-sensitive photoswitches could restore sight to those with macular degeneration
5. Light wine intake is associated with longer life expectancy in men
6. Light-based probe sees early cancers in first tests on human tissue
7. Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
8. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
9. Columbia research lifts major hurdle to gene therapy for cancer
10. Combination therapy boosts effectiveness of telomere-directed cancer cell death
11. Gene therapy converts dead bone graft to new, living tissue
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Light therapy may combat fungal infections new evidence suggests

(Date:8/28/2014)... examples of complex systems. Their infrastructure equipment requires ... cooling, transport to supply fuel, and ICT systems ... network chain is interconnected with a wider network ... of UK-based scientists has studied various aspects of ... been published in EPJ B by Gaihua Fu ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability in ... that occurs when the regions of the brain ... The use of non-invasive functional neuroimaging tools has ... dyslexia. However, most prior work has focused on ... a gap in our understanding of how multiple ...
(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Dyslexic readers have disrupted network connections in the brain 2Nanoscale assembly line 2Nanoscale assembly line 3
... of breast cancer that has few treatment options; , ... molecules called microRNA can be used to classify this ... new ways to identify the best therapy for individual ... COLUMBUS, Ohio A new, large-scale study ...
... debate over the use of animals in medical research ... viewpoints are becoming more nuanced, and new initiatives are ... report by The Hastings Center, "Animal Research Ethics: Evolving ... new Web site, animalresearch.thehastingscenter.org , a hub of ...
... at sea, a magnetic map is apparently responsible for their ... data collected over 56 years and reported online on February ... "To find their way back home across thousands of ... exists where they first enter the sea as juveniles," said ...
Cached Biology News:Triple-negative breast cancer subtypes identified using microRNA 2Triple-negative breast cancer subtypes identified using microRNA 3Hastings Center resources chart progress in debate over medical research with animals 2Hastings Center resources chart progress in debate over medical research with animals 3Magnetic map guides salmon home 2
(Date:8/28/2014)... important devices in spintronics, an electronic which is ... but also on their spin and the spin-related ... into magnetic signals and vice versa. Recently, the ... Institute of Physics at Johannes Gutenberg University Mainz ... and Japan, has for the first time realised ...
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson ... three industry veterans to its equity research team ... "Our ongoing expansion in equity research demonstrates our ... unique insights to enhance their investment decision making," ... at STRH.  "We continue to make significant investments ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... Pipeline Efforts at 27th Annual J.P. Morgan Healthcare Conference ... (Nasdaq: GHDX ) announced today that it ... 18-gene Oncotype DX(R) colon cancer assay. Utilizing more ... the validation study will use prospectively defined endpoints to ...
... Jan. 12 WaferGen Biosystems,Inc. (OTC Bulletin ... gene,expression, genotyping, cell biology and stem cell ... successfully demonstrated the,performance of the company,s SmartChip(TM) ... the platform,s ongoing alpha testing program. ...
... - Trial conducted by Novartis to evaluate safety and ... with ribavirin in patients with genotypes 2 and 3 ... Sciences, Inc. (Nasdaq: HGSI ) today announced ... trial that will evaluate the safety and efficacy of ...
Cached Biology Technology:Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 2Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 3Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 4Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 5WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 2WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 3WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 4WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 5Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 2Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 3Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 4Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 5
... IonQuest will provide great value plus ... detector has very high sensitivities and ... to the standard conductivity detector, the IonQuest ... as electrochemical, refractive index, UV/Visible, WaveQuest UV/Visible ...
Capture faint-light images without losing sensitivity or resolution. With its brand new hardware and interface design, the LAS-1000plus turns sample imaging into a simple process....
This pump accomodates StemSep ; pump feed columns of the following sizes : 0.3in., 0.5in., 0.6in., and 1.0in.....
Designed for use with the Agencourt CleanSEQ and Agencourt AMPure 384-well SPRI reagent kits. For use with 384-well thermal cycling plates....
Biology Products: