In its first laboratory tests on human tissue, a light-based probe built by researchers at Duke University's Pratt School of Engineering almost instantly detected the earliest signs of cancer in cells that line internal organs.
If the preliminary success of the "optical biopsy" is confirmed through clinical trials, such a device could ultimately provide a particular advantage for early diagnosis, treatment and prevention of many types of cancer, according to the researchers. The vast majority of cancers start in the body's epithelial cells, which line the mucous membranes in the lungs, esophagus and gut.
"About 85 percent of all cancers start in the epithelium. It may be, for example, brain cancer that causes a patient's death, but that cancer might have originated in the colon or other site of epithelial tissue," said Adam Wax, professor of biomedical engineering. "Being able to detect pre-cancer in epithelial tissues would therefore help prevent all types of cancer by catching it early, before it has a chance to develop further or spread."
In some instances, the technique, known as "fa/LCI" (frequency-domain angle-resolved low coherence interferometry), might ultimately enable doctors and their patients to avoid removal of tissue for biopsy, Wax said. In other instances, he added, fa/LCI could help physicians pinpoint suspicious cells during a traditional biopsy procedure, making it less likely for a cancerous lesion to escape detection.
Wax and his former graduate student John Pyhtila reported in the March 2007 issue of Gastrointestinal Endoscopy that their fiber-optic device reliably differentiated between healthy and precancerous digestive tissue taken from the stomach and esophagus of three patients known to have a precancerous form of a condition called Barrett's esophagus. In less than a second, their fa/LCI-enhanced version of an endoscope, instruments used to visualize internal organs, provided the clinical information
'"/>
Source:Duke University
Related biology news :
1. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
2. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
3. Products containing specific probes for detecting alternative splice forms protected
4. Duke engineers develop new 3-D cardiac imaging probe
5. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
6. A probe, not an echo
7. NASA probe could reveal comet life, scientists claim
8. Montreal researchers probe the genetic basis of memory
9. MBL researchers probe how an ancient microbe thrives and evolves without sex
10. Smart nanoprobes light up disease
11. Magnetic probe successfully tracks implanted cells in cancer patients
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |