Navigation Links
Light activated anticancer drug targeted to DNA using cisplatin like sub-units

One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approach to analog development is light activated drugs, or photodynamic therapy (PDT). Now a Virginia Tech chemistry-biology research team that has been working on both non-cisplatin drugs and cisplatin analogs has combined their findings to create a molecular complex (supramolecule) that exploits cisplatins tumor targeting to deliver a light activated drug.

The latest results from the group's research to create a DNA targeting, light activated anticancer drug will be presented at the 231st American Chemical Society national meeting in Atlanta on March 26-30.

Chemistry professor Karen J. Brewer reports that the group has developed supramolecular complexes that combine light-absorbing PDT agents and cisplatin like units. Previous anticancer molecules created by the group have contained platinum-based molecules that bind DNA. They have also developed new light activated systems able to photocleave DNA. This report combines these two approaches to target the drug to DNA using cisplatin like units, directing the light activation to tumor cells and the sub-cellular target, DNA.

"In the past, our light activated systems had to find the DNA within the cell, an often inefficient process. Now we have added the DNA targeting drug," Brewer said. "We were working on cisplatin analogs before, so we have tied it to light activated systems."

Cisplatin begins its interaction with cancer DNA by binding to the nitrogen atoms of the DNA bases, typically guanine. Our new supramolecules use this nitrogen-binding site to hold the light activated drug at the target until signaled to activate. Thus the new supramolecules can be delivered to the tumor site but remain ine
'"/>

Source:Virginia Tech


Page: 1 2

Related biology news :

1. Light therapy may combat fungal infections, new evidence suggests
2. New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice
3. Light guides flight of migratory birds
4. Light-sensitive photoswitches could restore sight to those with macular degeneration
5. Light wine intake is associated with longer life expectancy in men
6. Light-based probe sees early cancers in first tests on human tissue
7. Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
8. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
9. Reactivated gene shrinks tumors
10. New drug shows promise as powerful anticancer agent
11. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
Post Your Comments:
(Date:11/6/2014)... when that predator runs so fast that it essentially blinds ... the fastest creature on Earth. Some of these half-inch-long beetles ... miles per hour). The fastest human can do about five ... beetle, a person would have to hit 480 miles per ... peak speeds, everything becomes a blur. They can,t gather enough ...
(Date:11/5/2014)... Santamaria, associate professor of biology in the UTSA ... in the nation selected to receive a two-year ... for Exploratory Research (EAGER). The funding supports President ... researchers to create new technology that will demystify ... complex behaviors in neuroscience are broken into the ...
(Date:11/5/2014)... Janeiro, Brazil -Individuals show great diversity in their ability ... and females greatly differ in their perceptual evaluation of ... smell tests. , Sex differences in olfactory ... and may be connected to one,s perception of smell, ... Thus, women,s olfactory superiority has been suggested to be ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3The female nose always knows: Do women have more olfactory neurons? 2
... green tea dramatically boosted production of a group ... levels of these beneficial proteins, according to researchers ... published in the August issue of Cancer Epidemiology, ... Association for Cancer Research, suggest that a green ...
... has shattered a long-held belief that no direct pathway ... cell nucleus. (The cell is the smallest metabolically functional ... material outside of a cell can migrate into a ... phagocytosis, in which extracellular material is captured by a ...
... Alcohol and smoking can be harmful, if not deadly. ... environmental cues, genomic factors also play an important role. The ... complex interactions with the environment. Adoption and twin studies have ... be inherited. Such studies have provided evidence that ones sex ...
Cached Biology News:Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless 2New, more direct pathways from outside the cell-to-cell nuclei discovered 2New, more direct pathways from outside the cell-to-cell nuclei discovered 3Does the desire to consume alcohol and tobacco come from our genetic makeup? 2Does the desire to consume alcohol and tobacco come from our genetic makeup? 3
(Date:11/21/2014)... The California Healthcare Institute ... representing leading California academic institutions, biotechnology, medical device, ... today released a report revealing that California ... The trend shows a 4 percent increase between ... Industry Report indicates that, while biopharmaceutical and ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 2014 ... Ferrocyanide Industry” is a professional and in-depth research ... Sodium ferrocyanide information, like its definition, classification, ... industry overview. This report covers the international market ... global (such as the US, Europe, Asia, China, ...
(Date:11/21/2014)... ON , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... and nine month periods ended September 30, 2014.  Biorem,s complete 2014 ... ( www.sedar.com ). Financial Summary:Three-months ended September ... except per share data) , 2014 , ... 2,282 , 5,281 , 6,715 ...
(Date:11/18/2014)... Diego, CA (PRWEB) November 17, 2014 Athena ... of Salk , Dr. Beverly Emerson, a professor in the ... of genes. Her most recent discovery points to an “off ... Dr. Emerson’s career and how her local research is making ... will present her findings and then join host Cheryl K. ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... (Amex: IMA ) today announced that it has ... Australian company traded on,the Australian Securities Exchange, under which ... issued shares in Panbio for AUD 0.65 cash,per share. ... of,Panbio at approximately AUD 41 million, or approximately USD ...
... ExL Pharma, Cision and the PRSA have,joined ... biotech,public relations executives the first Pharmaceutical Public Relations,Symposium ... This,one-day event will cover the key issues and ... is under ongoing political and media scrutiny,most notably ...
... USC,s Increased Commitment to Research Advancements in Health ... Robust Life Science Industry in Los Angeles, LOS ... University of Southern California,s strengthened,commitment to advancing breakthrough research ... today the opening of an office,in the new Harlyne ...
Cached Biology Technology:Inverness Medical Innovations Agrees to Acquire Panbio Ltd. 2Leading Pharmaceutical Communication Executives Gather for the 1st Annual Pharmaceutical Public Relations Symposium 2The USC Stevens Institute for Innovation Opens Shop on US Health Sciences Campus 2The USC Stevens Institute for Innovation Opens Shop on US Health Sciences Campus 3The USC Stevens Institute for Innovation Opens Shop on US Health Sciences Campus 4
...
... high-density serum biomarker chip to profile the ... antibody chip containing 120 human cancer serum ... biomarker discovery scientists to study panels of ... therapy and the likelihood of recurrence of ...
... Ventilates and removes chemical fumes, ... exhaust. Bonded charcoal filters remove ... ensure safe exhaust flow speed ... access opening. Includes air speed ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
Biology Products: