Navigation Links
Life and death in the hippocampus: what young neurons need to survive

eks later, animals that received the virus showed fewer fluorescent neurons compared to mice injected with a benign virus lacking the shears, meaning fewer new neurons had survived originating from neural stem cells in which the NMDA receptor had been eliminated.

Listening to Gage, one gets the impression that the hippocampus is a dangerous place for a fledgling neuron trying to elbow its way into pre-existing networks. "It's rough in there!" he concedes. "The NMDA receptor-mediated event is a competition between mature cells vying for connectivity and young guys competing with both the mature cells and their peers to fit in. You are selecting for the cell that performs best in this environment."

The Gage lab previously showed that the rate at which new neurons emerge from stem cells depends on an animal's activity. "If you put animals in an enriched environment and give them access to running wheels, you increase survival of new brain cells," says Gage. "Now we show that stimulation may, in part, be mediated through the NMDA receptor."

Those studies had also shown that young and middle-aged "exercised" rats perform better on learning tasks such as maze swimming, indicating that new neurons are more than just a backup supply but actually enhance learning.

"Remarkably, new neurons are born in the hippocampus, a structure whose function is to acquire new information," says Gage. "That suggests that new cells are involved in how we learn."

This ongoing struggle for connections between young and mature neurons is apparently more than just a spectacle designed to keep Mother Nature amused: the fact that enhanced learning is correlated with adult neurogenesis suggests constant rearrangements within neural networks are absolutely necessary for learning to occur.

In fact, data emerging from studies in the Gage lab reinforces the commonly held belief that using one's brain cells is the best way to optimize brain funct
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. Enzyme allows B cells to resist death, leading to leukemia
3. Critical role in programmed cell death identified
4. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
5. The death of a very special chimpanzee
6. The very unexpected life and death of a leukemic cell
7. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
8. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
9. Hanging baskets of sex and death help fruit growers
10. UT Southwestern researchers discover master switch in cell death
11. Prescription pain patch abuse blamed for increase in deaths
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Life and death the hippocampus what young neurons need survive

(Date:9/30/2014)... and farm runoff in Hawaii is causing tumors in ... The study, published Tuesday in the peer-reviewed open-access journal ... ends up in algae that the turtles eat, promoting ... and internal organs. , Scientists at Duke University, the ... Administration (NOAA) conducted the study to better understand the ...
(Date:9/30/2014)... . , Animals ... such as exposure to predators. Researchers from the Max ... study on different populations of great tits that risk-taking ... High metabolic rates and low temperatures were associated with ... more likely to approach potential predators. , The readiness ...
(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
Breaking Biology News(10 mins):Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2Gut bacteria promote obesity in mice 2
... and use of commercial fertilisers and animal waste is ... our aquatic environment. Yet global food and bioenergy supplies ... Agriculture and Ecology at LIFE Faculty of Life ... massive resources at the development of sustainable animal waste ...
... a popular species of game fish in Lake Erie are ... most comprehensive to date on mercury levels in Great Lakes ... a semi-monthly journal. Satyendra Bhavsar and colleagues note ... lakes in the world. The lakes are of significant economic ...
... 20, 2010) -- The Howard Hughes Medical Institute (HHMI) ... Rice University,s successful undergraduate global health program Beyond Traditional ... million HHMI grant in 2006, challenges students to come ... developing world. The program has captured the imagination of ...
Cached Biology News:Massive resources now directed at sustainable animal waste technology 2HHMI renews grant for Rice's global health program 2
(Date:10/1/2014)... 2014 Award winning unified communications ... four new-hosted collaboration bundles that combine next generation ... conferencing experiences for low, flat rate fees. ... businesses have optimized solutions to meet their technology ... audio only minutes (1K, 5K, 10K increments) or ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... German . , ... in a semiconductor layer. Quantum dots are small structures that ... a short laser pulse is fired at the photonic crystal, ... a change in the electromagnetic field around it. This change ... by the dot. As soon as the refractive index recovers ...
(Date:9/30/2014)... Mass. Using a bio-mimicking analog of one ... grass, an international research team led by Alejandro ... taken a major step in developing long-sought polymer ... electricity for use in electronic devices. , ... Amherst and others at Stanford University and Dresden ...
Breaking Biology Technology:SoundConnect Launches New Audio, Web and Video Bundles 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... Berbee Information Networks Corporation , a privately held IT firm, ... an undisclosed sum. , ,Berbee said it expects to keep ... about 630 employees in all. Strategies & Solutions provides hardware, ... of business servers. , ,Berbee has regional offices throughout the ...
... during the 1990s, healthcare again faces the vexing ... in premiums and out-of-pocket costs for consumers ... time now clinical information technology has been seen ... millions of dollars in clinical systems such as ...
... , a business-process IT firm active in supply-chain software, says ... products for manufacturers. , ,RFID involves putting radio tags on ... Wal-Mart, for one, made sweeping mandates that its suppliers begin ... gave them an extension until the end of next 2006 ...
Cached Biology Technology:Innovative health care takes more than just IT automation 2Innovative health care takes more than just IT automation 3Innovative health care takes more than just IT automation 4
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures ... with nitrogen or other ... a low-humidity environment. HEPA ... and ionization modules also ...
... Low-noise, low-vibration filter/fan unit provides continuous vertical ... Class 100 (ISO 5) cleanliness standards ... to clean and disinfect , ... open to allow insertion of filling machines ...
... testing at various temperatures, this chamber ... a clean heating unit to maintain ... 140F. Transparent panels allow full visibility, ... access to the work area. Includes ...
Biology Products: