Leukemic cells find safe haven in bone marrow ( p>The study’s findings also suggest tha...)

Leukemic cells find safe haven in bone marrow

p>The study’s findings also suggest that drugs now being developed to block ASNS should be tested to see if they also prevent mesenchymal cells from making this amino acid. In addition, the ability of mesenchymal cells to make asparagine might be decreased by cancer drugs that are already known to disrupt the activity of those cells.

"Because asparaginase is so widely used to treat ALL, this new insight into how mesenchymal cells protect leukemic cells is very important," said Ching-Hon Pui, M.D., chair of the Oncology department and American Cancer Society Professor at St. Jude. "The more we learn about the molecular interactions between these cells, the more likely we’ll be able to enhance the anti-leukemic action of asparaginase and perhaps other anti-leukemic drugs as well," said Pui, a co-author of the paper. "That would reduce the recurrence rate of ALL and continue our successful efforts to increase the survival rate of ALL."

Previous research at St. Jude and elsewhere had shown that direct contact with bone marrow mesenchymal cells is essential for the long-term survival and multiplication of leukemic lymphoblasts. In the current study, the team found that the gene for ASNS was more than 20 times active in producing this enzyme in mesenchymal cells than in ALL cells.

Experiments performed by co-authors Shotaro Iwamoto, M.D., and Keichiro Mihara, postdoctoral fellows in Campana’s laboratory, demonstrated that ALL cells from different patients became much more resistant to asparaginase when cultured on top of a layer of mesenchymal cells. In order to determine whether it was the high levels of asparagine released by mesenchymal cells that protected ALL cells from asparaginase, the St. Jude team repeated the experiment, but blocked the ability of mesenchymal cells to make the ASNS enzyme and produce asparagine. In this case, the protective effect of mesenchymal cells was eliminated. Conversely, when the researchers caused the AS
'"/>

Source:St. Jude Children's Research Hospital

Page: 1 2 3
Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells

Post Your Comments:

(Date:6/18/2013)... the United Kingdom, the Energy Department,s National Renewable ... have recently published a paper describing a novel ... Limnoria quadripunctata , commonly known as the gribble. ... exhibit a relatively unique ability to produce their ... break down the biomass they eat. New biomass-degrading ...

(Date:6/18/2013)... Research Council, Laboratory of Molecular Biology, has been ... Young Investigator Award. Torrent is being recognized for ... algorithm to predict antimicrobial regions in proteins. Luis ... now applying this algorithm to interrogate full genomes ... with very appealing results." , Torrent obtained ...

(Date:6/18/2013)... 18, 2013 The herbal extract of a yellow-flowered ... to increase the lifespan of fruit fly populations by ... researchers. , But it,s how Rhodiola ... that grabbed the attention of study leaders Mahtab Jafari ... works in a manner completely unrelated to dietary restriction ...

Breaking Biology News(10 mins):Novel enzyme from tiny gribble could prove a boon for biofuels research 2 The American Society for Microbiology honors Marc Torrent 2 Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2

[0] Novel enzyme from tiny gribble could prove a boon for biofuels research [0] The American Society for Microbiology honors Marc Torrent [0] Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds

... In nature, ultraviolet radiation from sunlight is not the ... and females who choose to lay their eggs in the ... amphibian species out of harm,s way most of the time, ... of the long-toed salamander received lethal doses of UV across ...

... Researchers from the p53 Laboratory of Singapore,s Agency for ... makes feasible a unique method of cancer treatment. Their work, ... Differentiation today , offers new insight on how to ... genome, , to more effectively kill cancer cells while sparing ...

... 2010) - A technique pioneered in the Tissue Engineering ... Edward V. Zegarelli Professor of Dental Medicine at Columbia ... to a three-dimensional scaffold infused with growth factor, holding ... in as soon as nine weeks once implanted. ...

Cached Biology News:Ultraviolet radiation not culprit killing amphibians, research shows 2 Ultraviolet radiation not culprit killing amphibians, research shows 3 Singapore scientists exploit knowledge of p53 for increasing specificity of cancer treatments 2 Technique yields potential biological substitute for dental implants 2

Ultraviolet radiation not culprit killing amphibians, research shows Singapore scientists exploit knowledge of p53 for increasing specificity of cancer treatments Technique yields potential biological substitute for dental implants

(Date:6/19/2013)... Washington (PRWEB) June 18, 2013 A ... complex materials, costs and other trends will highlight technical ... Monterey, California this fall. In its 33rd year, the ... includes an exhibition of key suppliers, approximately 100 technical ... SPIE, the international society for optics and photonics ...

(Date:6/18/2013)... 18, 2013 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced its preliminary unaudited financial results for the fourth ... March 31, 2013. Fourth Quarter of ... quarter of fiscal 2013 increased by 33.3% to RMB133.0 ...

(Date:6/18/2013)... The human skin is the largest organ, ... human body part. Similar to the liver, or heart, the ... repair and grow. Recent reports from the mankatofreepress.com explained how ... as important as other life supporting organs. The article suggests ... cell reproduction, increase the appearance of skin, and fight off ...

(Date:6/18/2013)... 2013 regulated information — Global biopharmaceutical company UCB, ... announced the launch of a new Pledge campaign for ... The Pledge empowers the millions of Americans ... a personal commitment to demand more: greater understanding of ... and additional partial-onset seizure control. More information is available ...

[0] ‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology [0] China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 [0] Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin [0] Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy

... 4 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ... his research group at The Institute of Cancer ... testing combination treatment schedules,of reovirus and radiation in ... in,vivo. The paper, entitled "Enhanced In vitro and ...

... 2008) -- A University of Waterloo physics and astronomy ... in Science Magazine, shows how some solids behave like ... James Forrest and then-graduate student Zahra Fakhraai, take a ... substances using nanoscale technology. , They explore the properties ...

... 1 MannKind Corporation,(Nasdaq: MNKD ), focused on ... today that it will present at,the Merrill Lynch Global ... at 1:40 PM ET at the Grand Hyatt Hotel ... link to the live web cast of the,presentation in ...

Cached Biology Technology:Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Radiation Therapy 2 UW paper in Science shows how some solids mimic liquids on nanoscale 2

Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Radiation Therapy UW paper in Science shows how some solids mimic liquids on nanoscale MannKind to Present at the Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference

Anti-TWIK-1 Immunogen: Purified peptide from amino acids 53-69 of human TWIK-1 (Accession number O00180)....

Monoclonal 8C2.1 is specific for Bunyavirus G1 as tested by neutralization, immunoprecipitation and immunobinding assays....

BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...

...

Biology Products:

Rabbit Anti-TWIK-1 Antibody, Unconjugated from CHEMICON Anti-Bunyavirus (G1) Monoclonal Antibody, Unconjugated, Clone 8C2.1 from CHEMICON Rabbit Anti-BI-1 Polyclonal Antibody, Unconjugated from BioVision Capped Xef-1 RNA 0.05 ml from Ambion