Navigation Links
Leukemia drug turns mini-molecules up, cancer genes down

New research shows that a form of vitamin A used to treat acute promyelocytic leukemia induces changes in an unusual class of small molecules called microRNAs (miRNAs) in the leukemic cells.

The study also shows that three of these miRNAs inhibit the action of two genes important for cancer development, helping to explain how the drug works.

The drug is called all-trans-retinoic acid (ATRA) and it is considered the gold standard for treating the disease.

The study showed that ATRA raises the levels of three particular miRNAs in leukemia cells and that this rise coincides with a fall in activity of two important cancer-causing genes. The three are identified as miRNA-15b, miRNA-16-1 and let-7.

Two of these, miRNA-15b and miRNA-16-1, reduce the activity of the Bcl-2 gene, which is over-active in many kinds of cancer. The protein produced by this gene blocks the normal process of cell death and helps keep cancer cells alive long after they should have died.

The remaining miRNA molecule, let-7, lowered the activity of the Ras oncogene, an important cancer-causing gene. (Oncogenes are normal genes that when mutated lead to cancer.)

Researchers at the Ohio State University Comprehensive Cancer Center led the study, which was published in a recent issue of the journal Oncogene.

"The findings are important because they tell us that some miRNAs switch off genes that promote cancer," says first author Ramiro Garzon, a hematologist and oncologist at Ohio State's James Cancer Hospital and Solove Research Institute.

Acute promyelocytic leukemia occurs when cells that give rise to a form of white blood cell become stuck at an immature stage. The immature cells accumulate until they crowd out healthy white cells in the blood and bone marrow.

"Our findings suggest that these three miRNAs help re-program the malignant cells to a more normal state," Garzon says, "and that they are also impo
'"/>

Source:Ohio State University


Page: 1 2

Related biology news :

1. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
2. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
3. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
4. Loosen up, DNA: Leukemia gene changes genetic packaging
5. Lack of enzyme turns fat cells into fat burners
6. Programmable cells: Engineer turns bacteria into living computers
7. Gene therapy turns off mutation linked to Parkinsons disease
8. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
9. Jefferson researchers uncover new way nature turns genes on and off
10. Viral DNA sequence a possible trigger for breast cancer
11. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Leukemia drug turns mini molecules cancer genes down

(Date:8/26/2014)... a pen a New Zealand endemic tree has for the ... group of ,weedy, Australian shrubs and small trees. A New ... surprises and discover astonishing cryptic diversity behind what was long ... the open access journal PhytoKeys . , ... was one of the many discoveries made in the north-western ...
(Date:8/26/2014)... such as global warming and poverty the result ... fall on our failure as consumers to make ... in the Journal of Consumer Research , ... problems from governments to consumers and ultimately benefits ... politicians to encourage responsible consumption instead of implementing ...
(Date:8/26/2014)... planet can produce much more land-plant biomass the ... other terrestrial plant parts than previously thought. , ... and Technology , recalculates the theoretical limit of terrestrial ... than many current estimates allow. , "When you try ... to make some simplifying assumptions," said University of Illinois ...
Breaking Biology News(10 mins):And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 3An inconvenient truth: Does responsible consumption benefit corporations more than society? 2Study: Earth can sustain more terrestrial plant growth than previously thought 2Study: Earth can sustain more terrestrial plant growth than previously thought 3
... A new study by civil engineers at MIT shows that using ... by as much as 3 percent a savings that could ... or $15.6 billion at today,s oil prices. This would result in ... tons. The study, released in a recent peer-reviewed report, ...
... JOSE, Calif., May 22, 2012 /PRNewswire-iReach/ -- ... announces that Chief Technology Officer, Sebastien Taveau, will participate ... at NFC Solutions Summit 2012. The session will take place ... San Francisco Airport, in Burlingame, CA. At ...
... Hebrew University of Jerusalem have achieved, for the first ... of Fragile X patients. The discovery paves the way ... expression in Fragile X patients. Fragile X syndrome ... affecting hundreds of thousands of patients worldwide. The syndrome ...
Cached Biology News:Civil engineers find savings where the rubber meets the road 2Civil engineers find savings where the rubber meets the road 3Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012 2Stem cell research paves way for progress on dealing with Fragile X retardation 2
(Date:8/26/2014)... A team of engineers from Singapore has successfully ... (WSN) for satellite communications. , With the weight ... design, constructing a lightweight, low power-consuming, wireless communication ... satellite has always been a challenge for system ... Research Centre of Nanyang Technological University in Singapore ...
(Date:8/26/2014)... -- An analysis by Replikins, Ltd. of Pubmed data ... in Pubmed, has revealed extensive conservation and sharing of ... sharing of specific Replikin gene structures has permitted the ... did for the H5N1 influenza vaccine and the Taura ... to be effective (1,2). This Dengue ...
(Date:8/26/2014)... , Aug. 26, 2014 Technology ... the symbol (NUUU) has two (2) wholly- owned ... two subsidiaries harness scientifically advanced technology to provide ... NUUU,s Renuell Int,l, Inc. is launching ... skin care products that is made possible because ...
(Date:8/26/2014)... 2014 Genedata, a leading provider ... life science research, today announced the Genedata ... held in Asia, Europe, and North America during ... and leading research organizations will gather for annual ... studies, and upcoming challenges in all areas of ...
Breaking Biology Technology:ZigBee in the Sky 2Technology Applications International Corporation, Trading Symbol NUUU now trading on NASDAQ's Over the Counter Bulletin Board (OTC BB) 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3
... whopping portfolio of 16 Nanotechnology products and processes ... Release" organized to mark the fifty-second anniversary celebrations ... the portfolio, Director, Center of Excellence in Nanotechnology ... set of products and processes demonstrates potential development ...
... EAST LANSING, Mich. Researchers at Michigan State University ... while cleaning up nuclear waste and other toxic metals. ... and patented, are published in the current issue of ... The implications could eventually benefit sites forever changed ...
... WEST LAFAYETTE, Ind. - Researchers are making progress in ... sidestepping an obstacle thought to dramatically limit the material,s ... a one-atom-thick layer of carbon that conducts electricity with ... 2004 - which earned a Nobel Prize in physics ...
Cached Biology Technology:AIT unveils portfolio of 16 nanotechnology products 2Microbes generate electricity while cleaning up nuclear waste 2Innovation is step toward digital graphene transistors 2
Collected from 8-12 week old sexually mature rats. Pricing: $100/unit for 1 - 10 units...
PlusOne Acrylamide PAGE, 1 kg. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
... The RiboGreen RNA Quantitation Kit is ... systems for the quantitation of RNA ... approximately 1000-fold more sensitive than absorbance ... can be detected with fluorescence microplate ...
... GenoStat Inducible Expression System provides tightly regulated ... cells and is capable of repeated on/off ... mediated by the highly specific interaction between ... nuclear receptor complex. Gene expression levels are ...
Biology Products: