Navigation Links
Leukemia Drug Breakthrough Study In New England Journal Of Medicine

Alan List, M.D., leader of the Hematologic Malignancies Program at the H. Lee Moffitt Cancer Center & Research Institute, recently conducted a phase I/II trial of the experimental drug Revlimid showing promise as an innovative way to treat patients with myelodysplastic syndrome (MDS), a form of pre-leukemia. Given in pill form, Revlimid simultaneously blocks the growth of new blood vessels that nourish tumors (anti-angiogenesis) and stimulates the immune system to fight cancer cells. The study is reported in the Feb.10 issue of the New England Journal of Medicine.

Nearly 90 percent of MDS patients are anemic and require regular transfusions of red cells. In this study, 91 percent of the MDS patients with a chromosome abnormality named 5q minus syndrome became transfusion independent. The defective 5q chromosome abnormality may be linked to other serious cancers, including leukemias and small cell lung cancer.

In another finding of the same study, all the patients with the 5q deletion who became transfusion independent also went into cytogenetic remission, meaning that the chromosome abnormality disappeared.

List, a professor of interdisciplinary oncology at the University of South Florida, initially developed the phase I clinical trial of Revlimid for treatment of MDS following his laboratory observations that the agent improved the growth of red blood cell precursors from MDS bone marrow. Celgene will submit the seminal findings of List's phase I trial - along with data from two recent confirmatory phase II clinical trials performed nationwide involving more than 350 patients with red blood cell transfusion-dependent MDS - to the U.S. Food and Drug Administration in a new drug application (NDA) for Revlimid as an innovative approach to treat the anemia of MDS patients with the 5q minus deletion.

In 2001, the National Cancer Institute awarded Moffitt the status of a Comprehensive Cancer Center in recognition of its excellence in re
'"/>

Source:University Of South Florida Health Sciences Center


Page: 1 2

Related biology news :

1. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. Loosen up, DNA: Leukemia gene changes genetic packaging
4. Leukemia drug turns mini-molecules up, cancer genes down
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
7. Breakthrough isolating embryo-quality stem cells from blood
8. Breakthrough System for Understanding Ocean Plant Life Announced
9. Breakthrough: Scientists create worlds tiniest organic particles
10. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
11. Sciences Breakthrough of the Year: Watching evolution in action
Post Your Comments:
(Date:7/2/2009)... DNA-based reconstruction of the giant extinct moa...aves and rock shelters in New Zealand. , Researc...Research in New Zealand have identified four diffe... moa feathers believed to be at least 2500 years o...s and weighing 250 kilograms were the dominant an...
(Date:7/1/2009)...nson today announced that Axel Ullrich, Ph.D., dir...e Max Planck Institute of Biochemistry in Germany,...ies including Herceptin (trastuzumab) , is the win...cal Research. An independent committee of world-r...ptember 8 will receive a $100,000 prize during a c...
(Date:7/1/2009)...e European Molecular Biology Laboratory,s European... a major new e-science resource for biologists wh...H1N1 flu and cancer. , Biocatalogue.org , a cen...ices, is being officially launched today (Wednesda...nce on Intelligent Systems for Molecular Biology a...
(Date:7/1/2009)...f Science Education-Biology at the University of H...igating" mechanism of the desert rhubarb, which en...han otherwise expected for a plant in this region ...s is the first example of a self-irrigating plant ...ntains of Israel,s Negev desert, where average pre...
Breaking Biology News(10 mins):Scientists 'rebuild' giant moa using ancient DNA 2Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research 2New e-science service could accelerate cancer research 2Desert rhubarb -- a self-irrigating plant 2Women Believe Economy Is Top Issue in 2008 Election 10803 1Women Believe Economy Is Top Issue in 2008 Election 10803 2Women Believe Economy Is Top Issue in 2008 Election 10803 3Quit Smoking Drug May Raise Suicide Risk 10800 1Quit Smoking Drug May Raise Suicide Risk 10800 2Quit Smoking Drug May Raise Suicide Risk 10800 3NASA data link pollution to rainy summer days in the southeast 2101 1NASA data link pollution to rainy summer days in the southeast 2101 2NASA data link pollution to rainy summer days in the southeast 2101 3T cell immunity enhanced by timing of interleukin 7 therapy 10796 1T cell immunity enhanced by timing of interleukin 7 therapy 10796 2T cell immunity enhanced by timing of interleukin 7 therapy 10796 3
...swana, Harvard School of Public Health researchers...source-poor settings, who receive antiretroviral (...ose in the developed world. A fully supported heal...sure this success, according to data published in ...une Deficiency Syndromes (JAIDS). , More than 95 p...
... in animal models ?to treat cancer by disrupting t...of Pennsylvania School of Medicine completed a stu...ee a tumor,s blood perfusion and then to treat it ...ter three minutes of treatment at an intensity sim...about 2.5 watts), researchers observed that the tu...
...mechanism that regulates the way an internal organ...pare to divide, according to a report in Science E...ogy , and his colleagues at Yale study Trypanosoma...s. Like many parasites, it is exceptionally stream... making it ideal for studying processes of more co...
.... Really old, in fact, which comes as a surprise t...dying tree growth in the world,s largest tropical ...am, which includes UC Irvine,s Susan Trumbore, fou...ntimeters in diameter are more than 300 years old....750 to 1,000 years old. Study results appear in th...
Other Biology News:HIV-infected adults in Botswana respond positively to ARV therapy public treatment program 2Penn researchers study the use of ultrasound for treatment of cancer 2Sleeping sickness parasite shows how cells divide their insides 2Amazon trees much older than assumed, raising questions on global climate impact of region 2
(Date:7/2/2009)...rope have united to build the largest quantum key ...1 research and industrial organisations were reali...ent over an eight node, mesh network. , With an ...e longest link being 83 kilometres, the researcher...itute of Technology (formerly Austrian Research Ce...
(Date:7/2/2009)...swire-FirstCall/ - avVaa World Health Care Product... company, manufacturer and distributor of national...re products, announced the engagement of Koeppel D.... , Lorie Campbell-Farley, President/COO of avVaa...h Koeppel Direct, a world-class direct response te...
(Date:7/2/2009)...ecutes Master Services Agreement Covering Highly A..., Rochester, New York (PRW... leader in advanced cardiac safety biomarker devel...t has executed a master services agreement with a ...ac,s Highly Automated QT as well as Dynamic QTbtb ...
(Date:7/1/2009)...Newswire-Asia/ -- WuXi PharmaTech (Cayman) Inc.,(...an award from BASF for,excellent service and outs...esis for new crop-protection active ingredients. ,...h/20040705/CNM002LOGO ) , "We had been loo...s, and,today I think we have found one, a top-not...
Breaking Biology Technology:Researchers unite to distribute quantum keys 2avVaa World Health Care Products, Inc. Announces Engagement of Koeppel Direct for their DRTV-Direct Response Television Media Buying Campaign 2iCardiac Selected by Top 10 Pharmaceutical Company 2WuXi PharmaTech Receives Award from BASF 2
...- Ask a Wisconsin entrepreneur what,s vital to the...ely to get a shopping list as a definitive answer....g health insurance, protecting intellectual proper...mmon replies. , ,Holding down taxes? That,s on the...g order depends on the entrepreneur. Those who are...
...t one of our exclusive interview with new TDS Tel...rmation technology will play in transforming TDS f...is second part of the interview, he addresses the ...DS employee has a role to play in the innovation p...u describe your approach to driving the innovation...
...In an effort to address the lack of an effective d...erence, Mirus Bio Corp. has entered into a two-yea... to develop gene silencing methods in animal model...d the lack of effective delivery methods has been ... interference, a cellular process that regulates g...
...is is part II of a four-part series on intellectua...addressed how corporate officers can mitigate risk...s the same for trademarks and patents. , , Trade...In the trademark context, in order for an officer ...t personally take part in infringing activities or...
Other Biology Technology:High taxes and low rates of entrepreneurship - is there a relationship? 2High taxes and low rates of entrepreneurship - is there a relationship? 3New CEO at TDS on creating a culture of innovation (Part 2) 2New CEO at TDS on creating a culture of innovation (Part 2) 3New CEO at TDS on creating a culture of innovation (Part 2) 4Mirus Bio, Pfizer enter multimillion-dollar research agreement 2Intellectual Property: Are you an infringer? 2Intellectual Property: Are you an infringer? 3Intellectual Property: Are you an infringer? 4
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4.
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity.
...ersArray ChipWriter Pro systems are high-precision...or other biological samples. VersArray ChipWriter ... density, and reproducibility to deliver unparalle...ir modular component design and flexible software ...
Thermal printer paper is used with the thermal printer for the VersaFluor fluorometry systems. Supplied as 10 rolls.
Biology Products: