Navigation Links
Leptin has powerful effect on reward center in the brain

Leptin, a hormone critical for normal food intake and metabolism, exerts a strong effect on appetite by acting in the mid-brain region as well as in the hypothalamus, according to a Yale School of Medicine study in Neuron.

"Finding that metabolic hormones directly regulate the ventral tegmental area (VTA) of the mid-brain has profound implications for how researchers view the integration of metabolic signals in the brain," said the senior author, Ralph DiLeone, assistant professor of psychiatry.

In this study the researchers demonstrated that leptin signaling, via its receptor, occurs in the dopamine neurons in the VTA and that it results in decreased activity of these neurons.

"Metabolic control over dopamine neuron function in the VTA is likely to have consequences for a broad range of behaviors and associated pathologies," DiLeone said. "These include obesity, drug addiction, and other impulsive behavior."

Leptin's effect in the hypothalamus has been well studied, but it was not known how the hormone affected activity in the VTA, which contains dopamine neurons that are important in modulating motivated behavior, addiction and reward.

Reducing the function of the leptin receptor in the VTA region resulted in animals that ate too much and were hypersensitive to highly palatable foods. "Interestingly, despite the increase in food intake, these animals did not gain weight, possibly as a result of increased activity that was also seen in the animals," DiLeone said.

Food intake is influenced by signals that travel from the body to the brain. Leptin is one of the molecules that signals the brain to modulate food intake. It is produced in fat cells and informs the brain of the metabolic state. If animals are missing leptin, or the leptin receptor, they eat too much and become severely obese.


Source:Yale University

Page: 1

Related biology news :

1. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
2. Leptin found to control appetite and limb development in frogs
3. New drug shows promise as powerful anticancer agent
4. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
5. License to kill enables powerful immune attack cells in mice
6. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
7. A more powerful and efficient engine for rice: the C3-C4 challenge
8. Anticipation plays a powerful role in human memory, brain study finds
9. Gladstone investigators identify a new protective action for the powerful anti-HIV factor, APOBEC3G
10. Minuscule molecules pack a powerful punch
11. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
Post Your Comments:

(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... 23, 2016  The Prostate Cancer Foundation (PCF) is pleased to ... faster cures for prostate cancer. Members of the Class of 2016 were selected ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: