Navigation Links
Leptin has powerful effect on reward center in the brain

Leptin, a hormone critical for normal food intake and metabolism, exerts a strong effect on appetite by acting in the mid-brain region as well as in the hypothalamus, according to a Yale School of Medicine study in Neuron.

"Finding that metabolic hormones directly regulate the ventral tegmental area (VTA) of the mid-brain has profound implications for how researchers view the integration of metabolic signals in the brain," said the senior author, Ralph DiLeone, assistant professor of psychiatry.

In this study the researchers demonstrated that leptin signaling, via its receptor, occurs in the dopamine neurons in the VTA and that it results in decreased activity of these neurons.

"Metabolic control over dopamine neuron function in the VTA is likely to have consequences for a broad range of behaviors and associated pathologies," DiLeone said. "These include obesity, drug addiction, and other impulsive behavior."

Leptin's effect in the hypothalamus has been well studied, but it was not known how the hormone affected activity in the VTA, which contains dopamine neurons that are important in modulating motivated behavior, addiction and reward.

Reducing the function of the leptin receptor in the VTA region resulted in animals that ate too much and were hypersensitive to highly palatable foods. "Interestingly, despite the increase in food intake, these animals did not gain weight, possibly as a result of increased activity that was also seen in the animals," DiLeone said.

Food intake is influenced by signals that travel from the body to the brain. Leptin is one of the molecules that signals the brain to modulate food intake. It is produced in fat cells and informs the brain of the metabolic state. If animals are missing leptin, or the leptin receptor, they eat too much and become severely obese.


'"/>

Source:Yale University


Page: 1

Related biology news :

1. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
2. Leptin found to control appetite and limb development in frogs
3. New drug shows promise as powerful anticancer agent
4. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
5. License to kill enables powerful immune attack cells in mice
6. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
7. A more powerful and efficient engine for rice: the C3-C4 challenge
8. Anticipation plays a powerful role in human memory, brain study finds
9. Gladstone investigators identify a new protective action for the powerful anti-HIV factor, APOBEC3G
10. Minuscule molecules pack a powerful punch
11. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest ... ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials in ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... new line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC ... in Chicago. The result of a collaboration among several companies with expertise in ...
(Date:6/23/2016)... 2016 ReportsnReports.com adds 2016 ... its pharmaceuticals section with historic and forecast data ... more. Complete report on the Cell ... 15 companies and supported with 261 tables and ... . The Global Cell Culture Media ...
(Date:6/22/2016)... 22, 2016 Research and Markets has announced ... report to their offering. ... from $29.3 billion in 2013. The market is expected to grow ... 2015 to 2020, increasing from $50.6 billion in 2015 to $96.6 ... during the forecast period (2015 to 2020) are discussed. As well, ...
Breaking Biology Technology: