Navigation Links
Leprosy microbes lead scientists to immune discovery

With the unusual opportunity that human leprosy infections provide for study of human immune responses, scientists have discovered how the body's early warning system prompts a rapid immune response by two separate armies of defensive cells. The finding helps explain why, when threatened by microbes like the leprosy bug, this initial defense sometimes succeeds in limiting the damage, but in other cases yields to a dangerous, spreading infection.

Led by Stephan R. Krutzik of UCLA, a team of scientists that includes Barry R. Bloom, Dean of the Harvard School of Public Health, reported the work on May 8 in an advance online publication of Nature Medicine.

The researchers isolated immune cells in blood samples from healthy people and exposed the cells to a component of mycobacteria. The large white blood cells known as monocytes rapidly differentiated into the two distinct cell types, forming the body's emergency response to the detection of foreign bacteria. One category of defensive cells, macrophages, seek out and engulf the infectious bugs. The other group consists of dendritic, or "antigen-presenting" cells, which seize distinctive pieces of the enemy and use them to "educate" and stir up a second immune response, known as "adaptive" immunity.

Until now, laboratory dish experiments hadn't revealed that the instantaneous or "innate" immune reaction--discovered less than 10 years ago--is mounted by two differently-specialized cells. It had been thought that the initially responding cells were uniformly macrophages, equipped for the two roles. The innate response swings into action when invading microbes are detected by molecules called Toll-like receptors (TLRs) that stick out of the cell's outer membrane, serving as a trip-wire to raise the alarm. The TLRs spur the monocytes to differentiate into the two rapid response cell types.

Why this matters became strikingly clear when the scientists studied different forms of leprosy for the pr
'"/>

Source:Harvard School of Public Health


Page: 1 2

Related biology news :

1. Leprosy genome tells story of human migrations, French researchers report in Science
2. International Team Determines Geographic Origin of Leprosy
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Harnessing microbes, one by one, to build a better nanoworld
6. Could microbes solve Russias chemical weapons conundrum?
7. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
8. Freeze-dried mats of microbes awaken in Antarctic streambed
9. Understanding the oceans microbes is key to the Earths future
10. Wisconsin scientists discover a master key to microbes pathogenic lifestyles
11. New method for identifying microbes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Leprosy microbes lead scientists immune discovery

(Date:9/29/2014)... President Juan Manuel Santos has presented Dr. Cristin ... Society, with the prestigious Order of San Carlos. ... citizens, foreign civilians and military officers who have ... the field of international relations. , An international ... Samper was invited to the Colombian Residence in ...
(Date:9/29/2014)... article published online in Behavioral Brain Research ... brain as a result of chronic alcohol exposure that ... , Clinical assessments and research indicate that individuals with ... This can occur when people are actively drinking, when ... abstaining. , "Sleep-wake disturbances can last for months, ...
(Date:9/29/2014)... or esoteric. Yet in the modern world, it plays ... and a decisive role in the discovery and development ... UC Santa Barbara,s Paul Atzberger, a professor in the ... engineering, often works in areas where science and math ... Proceedings of the National Academy of Science ...
Breaking Biology News(10 mins):At the interface of math and science 2At the interface of math and science 3At the interface of math and science 4
... Materials engineers have created a new type of membrane ... be used for environmental cleanup, water purification and industrial ... conventional filters for separating oil from water and works ... usually mutually exclusive. Researchers attached the material to a ...
... the Netherlands Royal Academy of Arts and Sciences (KNAW) ... a new research programme: the Joint Scientific Thematic Research ... and the Academy will work together on developing bilateral ... and the Academy launched the joint research programme during ...
... Journal of Preventive Medicine special issue on climate ... Climate Changing People" conference today in Los Angeles. ... MD, DrPH, speaking about the impacts of climate change ... public health challenge. Health professionals need to understand the ...
Cached Biology News:New filtering technology has environmental, industrial applications 2New filtering technology has environmental, industrial applications 3NWO and Academy launch research program with China 2Issues at intersection of climate change and health impact global well-being 2Issues at intersection of climate change and health impact global well-being 3Issues at intersection of climate change and health impact global well-being 4
(Date:9/29/2014)... Claremont, CA (PRWEB) September 30, 2014 ... 1 million burn injuries require medical attention. In ... and brings serious complications to battlefield medical care. ... in Iraq and Afghanistan. Burn wounds heal slowly, ... that can be excessive, physically debilitating and functionally ...
(Date:9/29/2014)... in Iraq and Afghanistan, more than 300,000 soldiers have ... caused by exposure to bomb blasts and in ... of traumatic brain injury can range from the mild, ... impairments in memory and cognition. , Since 2007, ... importance and complexity of this problem, and has made ...
(Date:9/29/2014)... Research and Markets  has announced the ... & Services, End-User , Application - Global Forecast to ... The global oligonucleotide synthesis market is expected to reach ... growing at a CAGR of 9.8% from 2014 to ... the basis of products and services, applications, end users, ...
(Date:9/29/2014)... challenges in food security, emerging diseases and biodiversity ... published online in Science Express that ... of Arizona College of Agriculture and Life Sciences. ... of nine scientists has reviewed progress in addressing ... and environmental management using approaches that consider evolutionary ...
Breaking Biology Technology:Faster Healing with Fewer Scars 2Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3
... Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) management will present at the 2009 BIO International Convention at ... of Building A, Level 3. , ... ... 10:40 AM Eastern/4:40 PM Central European/7:40 AM Pacific, ...
... (OTC Bulletin Board: TBIO) today announced financial results for the ... are presented in the tables that follow.The Company reported a ... first quarter of 2009 as compared to a net income ... of 2008.Net sales from continuing operations were $5.0 million during ...
... Microtest Laboratories , a leading single source provider ... current suite of analytical testing and ... dissolution testing is the perfect complement to ... Scientific Founder of Microtest Laboratories ( www.microtestlabs.com ). ...
Cached Biology Technology:Transgenomic, Inc. Reports First Quarter 2009 Results 2Transgenomic, Inc. Reports First Quarter 2009 Results 3Transgenomic, Inc. Reports First Quarter 2009 Results 4Transgenomic, Inc. Reports First Quarter 2009 Results 5Transgenomic, Inc. Reports First Quarter 2009 Results 6Transgenomic, Inc. Reports First Quarter 2009 Results 7Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 2Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 3
Tumor Suppressor Sampler Kit 10 mu g each...
AMAP Multi Site-directed Mutagenesis Kit Research Focus: other Storage Temperature: -20C Shipping Temperature: dry ice...
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Biology Products: