Navigation Links
Legume compounds may help cancer treatment

The ARC Centre of Excellence for Integrative Legume Research (CILR) has lodged a complete patent application for compounds to treat cancer.

CILR researchers screened legumes (plants which obtain useable nitrogen from soil bacteria in their roots) for biological activity and they identified a number of compounds which could potentially prevent the formation of a blood supply to tumours. Without an adequate blood supply tumours stop growing and ultimately can regress.

The research has attracted major international interest for intensive collaboration and joint development.

The discovery has resulted in a formal research collaboration which is currently underway with French "CSIRO-equivalent" Centre National de la Recherche Scientifique. Co-investment discussions are also in progress with a New Zealand company.

The CILR formed a commercialisation business "Meristomics" last October to commercialise plant research discoveries. CILR's partner universities (the University of Queensland, Australian National University, University of Newcastle and University of Melbourne) passed on their commercialisation rights to Uniquest Pty Ltd, the University of Queensland's main commercialisation company.

Meristomics Chief Executive Officer Ian Harris said successful completion of this patent demonstrated that Meristomics was an effective model for commercialisation involving multiple partner universities.

"Through UniQuest, Meristomics had immediate access to substantial commercial expertise and is looking to build on its patent success by attracting further funding to progress the research," Mr Harris said.

The anti-cancer molecules are produced by legumes during the early symbiotic relationship with soil bacteria known as rhizobia. Rhizobia induce legumes to form tiny new root organs called "root nodules." The bacteria live in the nodules and provide the plant with useable nitrogen it can convert into proteins.

CILR Chief Investigator Professor Chris Parish's group, based at ANU's John Curtin School of Medical Research, developed the bioassay used to identify the compounds as potential therapeutic agents.

"We have identified several compounds derived from the legume interaction with rhizobium bacteria that show strong anti-angiogenic activity.

"They are promising therapeutic molecules which clearly warrant further investigation," Professor Parish said.

CILR Director Professor Peter Gresshoff said the current research success highlighted the importance of a critical mass of multidisciplinary biological scientists working together.

"The CILR was formed in 2003 through the Australian Research Council (ARC) Centres of Excellence scheme to create the scale and focus required to build on existing research strengths through collaboration, and to be internationally competitive.

"ARC core funding and major support through Queensland Government Smart State research funding has been vital in building capacity. It has enabled this marvellous research outcome," Professor Gresshoff said.


'"/>

Source:Research Australia


Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Metal-containing compounds show promise as HIV weapon
7. Seaweed yields new compounds with pharmaceutical potential
8. Phenolic compounds may explain Mediterranean diet benefits
9. Marijuana-like compounds suppress the immune response
10. Microbes transform safest PBDEs into more harmful compounds
11. Harvard scientists identify compounds that stimulate stem cell growth in the brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
(Date:3/15/2016)... New York , March 15, 2016 ... new market report published by Transparency Market Research "Digital Door ... Trends and Forecast 2015 - 2023," the global digital door ... US$ 731.9 Mn in 2014 and is forecast to grow ... 2023. Growth of micro, small and medium enterprises (MSMEs) across ...
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... http://www.apimages.com ) - --> - Renvoi : ... - --> --> ... solutions biométriques, fournit de nouveaux lecteurs d,empreintes digitales ... LF10 de DERMALOG sera utilisé pour produire des ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Md. (PRWEB) , ... May 25, 2016 , ... ... request for information (RFI) issued by the Office of the National Coordinator for ... patient experience, and determines if clinically relevant data were available when and where ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Lady had been ... tore her cruciate ligament in her left knee. Lady’s owner Hannah sought the help ... Florida board-certified veterinary surgeon, to repair her cruciate ligament and help with the pain ...
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
(Date:5/23/2016)... ... ... The need for blood donations in South Texas and across the nation is growing. , ... Center, blood donations are on the decline. In fact, donations across the country are at ... South Texas in the last four years alone. , There is no substitute for blood. ...
Breaking Biology Technology: