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Left-right wiring determined by neural communication in the embryonic worm

Most animals appear symmetrical at first glance, but we're full of internal lop-sidedness. From the hand used to pick up a pencil or throw a baseball, to where language is generated in the brain, to the orientation of our internal organs, humans are a glut of asymmetries. Worms aren't so different: The roundworm Caenorhabditis elegans has nerves on its left and right sides that perform different functions. Like handedness, the determination of which nerves develop on which side seems random from worm to worm.

But now, Rockefeller University and Howard Hughes Medical Institute scientists working to demystify the worm's asymmetry have discovered that the arbitrary left-right configurations of two types of olfactory neurons are established during development. In a study released in the May 18 issue of Cell, the researchers show that embryonic worms have a system of gap junctions -- "broadband" communication channels through which cells pass many kinds of molecules and electrical signals -- that allow growing neurons on the left and right to communicate with each other, a system that dissolves as the worm develops.

Every neuron in the adult C. elegans has been mapped and named. Handedness researchers are particularly interested in two olfactory neurons, AWCON and AWCOFF, one each on the left and right side of the worm's body. AWCON has one set of responsibilities, while AWCOFF has a totally different set of functions. Which side houses each of the nerves -- right or left -- appears to be random, with their positions reversed about 50 percent of the time. "What makes this an interesting puzzle to solve is understanding how the left and the right side become different from each other, and how they coordinate their activity so that every worm still has exactly one of each type of cell," says the paper's senior author Cori Bargmann, Torsten N. Wiesel Professor and head of the Laboratory of Neural Circuits and Behavior at Rockefeller. "What is it that sets u
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Source:Rockefeller University


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