Navigation Links
Learning the language of DNA

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

A senior member of the consortium and IMB researcher Professor David Hume said transcriptome describes all of the information read from the genome by a cell at any given time.

"Essentially, we need to understand the language that cells use to read DNA in order to know how processes in the body are controlled," Professor Hume said.

"This knowledge will be a major resource to the biomedical research community."

Part of understanding the language of cells lies in identifying promoters - the DNA regions at the start of genes that regulate their activity.

"We have identified the core promoters of the large majority of genes in the mouse and human genomes, expanding the number of known promoters by five- to ten-fold," Professor Hume said.

The findings of the consortium have also upended the traditional view that each gene has a single promoter and a single starting position.

The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of start sites.

This new model may help explain why some organisms, such as humans, are much more complex than simple organisms such as worms, despite having a similar number of genes.

If some genes have a broad range of start sites, individual species can differ subtly in the way they control these genes, meaning the genes can evolve faster, and organisms with these genes can become more complex.

The consortium also found that many pseudogenes ?traditionally thought to be "fossils" of ancient genes ?are actually active , and are therefore likely to have some as yet unknown function.

The results obtained by the FANTOM consortium, led by the Japanese scientific institute RIKEN and Genome Network Project, have been published in the current edition of the prestigious journal Nature Genetics in a paper of which Professor Hume is corresponding author and first co-author.


'"/>

Source:Research Australia


Related biology news :

1. Learning to fight an adversary that wont stay down
2. Bird Brains Show How Trial and Error May Contribute to Learning
3. Learning how SARS spikes its quarry
4. Learning to love bacteria: Stanford scientist highlights bugs benefits
5. Learning and memory stimulated by gut hormone
6. Learning during sleep?
7. RNA project to create language for scientists worldwide
8. Uniquely human component of language found in gregarious birds
9. Warbling whales speak a language all their own
10. Computer scientists unravel language of surgery
11. Uniform language for describing genes of pathogenic and beneficial microbes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences ... life sciences and healthcare industries, is pleased to announce Holger Braemer as ... subsidiary “USDM Europe GmbH” based in Germany. , Braemer is an integral part ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... advanced technology applications, announced today that Chief Executive Officer (CEO) Debbie Gustafson has ... is the global industry association connecting the electronics manufacturing supply chain. The ...
(Date:4/20/2017)... Israel , April 20, 2017  BrainStorm Cell ... cell technologies for neurodegenerative diseases, announced today that Chaim ... for Regenerative Medicine,s (ARM) 5 th Annual Cell & ... 09:40 EDT in Boston . ... Medical Officer & Chief Operating Officer, will participate in a ...
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... Alisa Wright, ... Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , ... Pharmacy Program for achievements in their careers and other scientific endeavors. , Wright ...
Breaking Biology Technology: