Navigation Links
Learning the language of DNA

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

A senior member of the consortium and IMB researcher Professor David Hume said transcriptome describes all of the information read from the genome by a cell at any given time.

"Essentially, we need to understand the language that cells use to read DNA in order to know how processes in the body are controlled," Professor Hume said.

"This knowledge will be a major resource to the biomedical research community."

Part of understanding the language of cells lies in identifying promoters - the DNA regions at the start of genes that regulate their activity.

"We have identified the core promoters of the large majority of genes in the mouse and human genomes, expanding the number of known promoters by five- to ten-fold," Professor Hume said.

The findings of the consortium have also upended the traditional view that each gene has a single promoter and a single starting position.

The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of start sites.

This new model may help explain why some organisms, such as humans, are much more complex than simple organisms such as worms, despite having a similar number of genes.

If some genes have a broad range of start sites, individual species can differ subtly in the way they control these genes, meaning the genes can evolve faster, and organisms with these genes can become more complex.

The consortium also found that many pseudogenes ?traditionally thought to be "fossils" of ancient genes ?are actually active , and are therefore likely to have some as yet unknown function.

The results obtained by the FANTOM consortium, led by the Japanese scientific institute RIKEN and Genome Network Project, have been published in the current edition of the prestigious journal Nature Genetics in a paper of which Professor Hume is corresponding author and first co-author.


'"/>

Source:Research Australia


Related biology news :

1. Learning to fight an adversary that wont stay down
2. Bird Brains Show How Trial and Error May Contribute to Learning
3. Learning how SARS spikes its quarry
4. Learning to love bacteria: Stanford scientist highlights bugs benefits
5. Learning and memory stimulated by gut hormone
6. Learning during sleep?
7. RNA project to create language for scientists worldwide
8. Uniquely human component of language found in gregarious birds
9. Warbling whales speak a language all their own
10. Computer scientists unravel language of surgery
11. Uniform language for describing genes of pathogenic and beneficial microbes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility supports the American ... bringing new hope for prospective parents who are challenged with costs of treatment. ... World Health Organization’s designation in hopes of changing the way health insurers, governments ...
(Date:6/22/2017)... ... June 22, 2017 , ... RURO, Inc., a ... version 6.5, a content-packed update to the Limfinity® framework. , LimitLIS® and other ... more diverse base of customers among labs and other businesses. Limfinity® 6.5 adds ...
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/20/2017)... ... June 20, 2017 , ... GigaGen Inc ., ... immune repertoires, announces launch of its new Surge(TM) Discovery service at ... of GigaGen, will present on Surge at the conference. , Surge is the ...
Breaking Biology Technology: