Navigation Links
Leading reason for corneal transplants comes into focus

Guided by families with an unusual number of cases, scientists at Johns Hopkins have discovered the genetic origins of at least one form of Fuchs corneal dystrophy, FCD, the leading reason for corneal transplantation in the United States.

In one form or another, FCD's trademark deterioration of the cells covering the clear, outermost lens of the eye affects more than 4 percent of the population over 40. Late in life, the dystrophy causes swelling of the cornea and can severely affect vision, making it impossible to see well even with glasses or contact lenses. It's believed that various forms of FCD are due to multiple gene mutations.

In a report in the September issue of Investigative Ophthalmology, a team led by Hopkins ophthalmologist John Gottsch, M.D., says they were able to map a common form of Fuchs, found most often in women, to chromosome 18.

"Finding this chromosomal locus is putting us in the right neighborhood to find culprit genes," says Gottsch. "Now we have to start knocking on every door."

Gottsch is heartened by success with earlier Fuchs gene-hunting studies. The Hopkins group tracked down its first FCD-related gene in a Virginia family with multiple, early onset cases. That gene, labeled COL8A2, was mapped to chromosome 1.

Prior to that, a large Indiana family with FCD, including a boy of 10, led the team to yet another gene variant, on chromosome 13.

The scientists use linkage analysis, a process-of-elimination gene-hunting technique that analyzes inheritance patterns in families with relatively large numbers of affected individuals and trace genetic traits co-inherited or "linked" with the disorder. Researchers search for a common location for all the linked traits until they wind up with a single chromosome address.

In his latest study, Gottsch used not only linkage analysis but also a method of identifying variations in DNA sequences to examine three FCD families in which
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Leading scientists rank endangered dolphins, porpoises most in need of immediate action
2. Leading lampreys to slaughter: Pheromone for scourge of Great Lakes identified
3. Bobbing birds do it for a reason
4. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
5. A reason why video games are hard to give up
6. Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease
7. Stem cell transplants improve recovery in animal models for stroke, cerebral palsy
8. Predicting successful outcomes in living-donor liver transplants
9. What animals can tell us about hemorrhage, organ transplants and aging
10. Protein may hold key to decreasing organ dysfunction rates in heart transplants
11. Stem cell transplants explored at Stanford as a possible treatment for hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Leading reason for corneal transplants comes into focus

(Date:8/18/2015)... 17, 2015 Research and Markets ( ... "Global Biometric Authentication & Identification Market: Focus ... Forecast, 2015-2020" report to their offering. ... systems market is expected to grow at an ... and generate over $25 billion (approximately) by 2020 ...
(Date:8/12/2015)... 12, 2015 As the digital ... innovation and advanced biometrics technology is accelerating beyond expectations.  ... rely on using their credit cards, the digital currency, ... for payment services led by companies in the space ... Google, Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
(Date:8/11/2015)... August 11, 2015 Today, ZUK announced its ... as well as expected revenues in 2015 that relate to sales ... revenue guidance of approximately 2,200 MSEK for 2015. Jörgen ... prominent smartphone manufacturer in China ... selected FPC1 155 for Z1 ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... has renewed its prestigious Clinical and Translational Science ... (STSI) in the amount of $29 million over ... in genomics, wireless technology and bioinformatics toward individualizing ... between Scripps Health and The Scripps Research Institute ...
... In the dog days of summer, female edible dormice ( ... immediately after this energy-intensive period they start to replenish their ... habit seems to give the animals a pleasant taste and ... Romans even kept them in captivity to fatten them up ...
... a high school student led to the youngest, smallest ... iconic tube-crested dinosaur Parasaurolophus . The discovery, announced ... at The Webb Schools, shows that the prehistoric plant-eater ... birthday. Three-dimensional scans of nearly the entire fossil are ...
Cached Biology News:NIH awards Scripps Translational Science Institute $29 million grant 2NIH awards Scripps Translational Science Institute $29 million grant 3Fat and fit 2High school student discovers skeleton of baby dinosaur 2High school student discovers skeleton of baby dinosaur 3
(Date:9/3/2015)... , Sept. 3, 2015 /PRNewswire/ - bioLytical Laboratories ... to announce its study " Sensitivity of a rapid ... is enhanced by its affinity for HIV gp41 IgM ... Clinical Virology.  This study highlights INSTI,s ability to detect ... their findings at the 8 th annual International ...
(Date:9/3/2015)... MA (PRWEB) , ... September 03, 2015 , ... If ... conference in Boston this October, you will also want to sign up for ... Sunday, October 18th. The tour includes a walk through of the (8) chemistry ...
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biochips and Microarrays - ... This report is an analysis of ... report starts with a description of technologies as ... array comparative genomic hybridization (CGH), copy number variation ...
(Date:9/2/2015)... Biovista Inc. is glad to ... BeHEARD science challenge, a global competition hosted by the ... to the latest life science innovations and technologies. ... analytics capability to support Steven Laffoon and ... of Niemann-Pick Disease Type A (NPA), a rare and ...
Breaking Biology Technology:bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 2bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 3Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2
... Inc. (Nasdaq: EXEL ) announced today that it will ... from 10:00 a.m. ET / 7:00,a.m. PT to 2:00 p.m. ... will,discuss updates to its development pipeline, its collaborations, including,those with ... Speakers: -- George Scangos, PhD, President & ...
... Life scientists are highly,engaged users of a variety ... worldwide study of more than 1,500 scientists released ... research services. The,survey, co-sponsored by BioInformatics, LLC and ... and marketing,agency, found that 77 percent of life ...
... antibody,engineering company developing novel antibodies and antibody fragments,based on ... raised EUR 3.0 million from Novo A/S in a ... by Aescap Venture and Atlas Venture.,After this Second Closing, ... EUR 9.0 million. In total, the Company has raised ...
Cached Biology Technology:Reminder: Exelixis Announces December 5 Webcast of Its Third Annual R&D Day 2Scientists Using Social Media to Inform Lab Purchasing Decisions 2Antibody Engineering Company f-star Raises EUR 3.0 Million in a Second Closing of its Series A Financing Round From Novo A/S 2Antibody Engineering Company f-star Raises EUR 3.0 Million in a Second Closing of its Series A Financing Round From Novo A/S 3
... faster than Bromophenol blue,or methylene blue ... dye migrates with DNA between 10 ... this size,prevents the obscuring of smaller ... of DNA migration.,The Orange G Loading ...
... for JASCO HPLC systems. , Integrated Instrument Control , ... EZChrom Elite can be ... HPLC systems. This provides a completely integrated system to control instrument's ... run. , ...
... Gel loading solution, Type ... non-denaturing polyacrylamide and agarose ... acids and offers the ... dyes (bromphenol blue and ...
Rabbit polyclonal to QKI...
Biology Products: