Navigation Links
Lead with a poisonous electron shield

It has been speculated that lead poisoning may have played a role in the fall of the Roman Empire: it is thought to have been caused by the concentration of grape juice in lead containers. Though the introduction of lead-free gasoline has reduced damage to the environment, the annual production of lead continues to increase worldwide because lead is still used in batteries, glass, and electronic components. However, there has thus far been little research into what, at a molecular level, causes the toxic effects of lead. French researchers have now applied quantum chemistry to very simple enzyme models and gained new insights. As they have reported in Angewandte Chemie, it seems that the lead's "electron shield" is the main culprit.

Lead does the most damage to the nervous system, kidneys, liver, brain, and blood. These kinds of damage are especially severe for children as they can be irreversible. Complexation agents that grab onto the metal cations are used as antidotes. However, these agents are not lead-specific, meaning that they also remove other important metal cations from the body.

C. Gourlaouen and O. Parisel (Laboratoire de Chimie Théorique, Université Paris 6) took a closer look at two proteins to which lead likes to bind. Calmodulin, a calcium-binding protein, plays an important role in regulating and transporting the calcium cation in the human body. A calcium ion binds to seven ligands at the active centers of the enzyme. If one of the four possible calcium ions of calmodulin is replaced by lead, the lead ion remains roughly heptacoordinated, but this active center becomes distorted and inefficient; the three remaining sites get a reduced efficiency.

d-Aminolevulinic acid dehydratase is essential for the biosynthesis of hemoglobin. Inhibition of this enzyme disrupts the formation of blood to the point of anemia. At the active center, a zinc ion binds to four ligands, three of which involve a sulfur atom. When lead replaces z
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. CU, USDA team to curb two invasive, poisonous vines
2. Bioelectronic ‘signatures?hold key to DNA mutations
3. Researchers make long DNA wires for future medical and electronic devices
4. UC Davis researchers move biotechnology closer to replacing electronic pacemakers
5. Juiced-up battery fueled by sugar could power small portable electronics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lead with poisonous electron shield

(Date:9/2/2014)... With their long, spiky legs and their propensity for ... stuff of nightmares. And now research from North Carolina ... spread into homes across the eastern United States. , ... or pose any kind of threat to humans," says ... State and lead author of a paper about the ...
(Date:9/1/2014)... An increasing amount of research shows an association between ... sedentary lifestyle. Now, a new Cornell University study points ... programs might lead people to eat twice as much ... an action movie while snacking your mouth will see ... on the new article just published in the ...
(Date:9/1/2014)... after birth, every child in the U.S. undergoes a ... conditions, including sickle cell disease. Thousands of children born ... many suffer and die from the disease each year. ... to at least some of those deaths. , ... in the lab of George Whitesides, the Woodford L. ...
Breaking Biology News(10 mins):Researchers find Asian camel crickets now common in US homes 2Can action movies make you fat? 2Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3
... Who is related to whom, who begat whom, how did ... reptiles. In 2011, his fieldwork in Sri Lanka studying ... identity of 60 known species of snakes. With Sri Lankan ... amphibians and reptiles, and Dushantha Kandambi, a local naturalist and ...
... Copenhagen, Denmark, Shenzhen, China. Tue., 12 March 2013 ... world,s largest genomics organization, will be working together aiming ... genomics and bioinformatics capabilities of both institutions. This partnership ... food security, energy and health. , Prof Richard Cogdell, ...
... to have an ambiguous, obscure or hidden meaning. In ... are hidden inside their genes. Two University of ... tiny clams, long believed to be members of the ... along the rocky shores of southern Australia for millions ...
Cached Biology News:Sri Lankan snake study reveals new species, rich biodiversity in island country 2BGI and TGAC join efforts to tackle global challenges in food security, energy and health 2Cryptic clams: U-M biologists find species hiding in plain view 2Cryptic clams: U-M biologists find species hiding in plain view 3
(Date:9/2/2014)...  Technology Applications International Corporation (the "Company" or "NUUU")(OTC ... Int,l, Inc. has signed an additional exclusive licensing agreement ... the Johnson Space Center in Houston ... Charles J. Scimeca , ... our latest, exclusive agreement with NASA. In addition to ...
(Date:9/2/2014)... Orexigen Therapeutics, Inc. (Nasdaq: OREX ... Office (PTO) has issued a patent related to NB32, ... NB32 is a fixed-dose combination of naltrexone sustained release ... 8,815,889 claims methods for treating insulin resistance using a ... 2024. If NB32 is approved for use in ...
(Date:9/2/2014)... 2014  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... candidates targeting specific pathogens that cause serious infections ... final preclinical toxicology study of SYN-004. Per U.S. ... study was required to move the Company,s lead ... devastating effects of Clostridium difficile (C. difficile), ...
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an intellectual ... of intellectual property, today announced that the United States ... the Company in the month of August that are ... The issued patents are: ... issued August 19, 2014; and , U.S.RE45,095 issued ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2
... AdvanceBio LLC, a Cincinnati-based advanced biofuel technology company, ... fuel ethanol process. The process is capable ... sugar beet and other similar crops as feedstock for ... generating zero liquid waste. When built in ...
... TIRAT CARMEL, Israel, August 31, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Aug. 30 Marrone Bio Innovations (MBI) ... for the control of invasive mussels, at the ... San Diego, California, August 29 to September 2, 2010. ... representing academia, industry, government agencies, NGOs and other stakeholders ...
Cached Biology Technology:Zero Discharge Sweet Sorghum Ethanol Process Development 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 3InSightec Treats First Prostate Cancer Patients in Clinical Trials 4InSightec Treats First Prostate Cancer Patients in Clinical Trials 5InSightec Treats First Prostate Cancer Patients in Clinical Trials 6InSightec Treats First Prostate Cancer Patients in Clinical Trials 7InSightec Treats First Prostate Cancer Patients in Clinical Trials 8Marrone Bio Innovations to Present Invasive Mussel Control Solution 2
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
The F40 pump maintenance kit is used to service one F40 pump of a BioLogic DuoFlow workstation. It includes 2 piston seals, 4 check valves, seal removal tool, and 2 O-rings....
...
...
Biology Products: