Navigation Links
Largest synthetic gene ever built offers insights into anti-malarial drug resistance

and divides there, and then ruptures liver cells, spewing many new parasites into the blood. A fever results from the infection, and this is followed by repeated cycles of mounting parasitic reproduction within red blood cells and accompanying fever. During red blood cell infection, P. falciparum degrades the hemoglobin in the red cell, producing a toxic byproduct known as heme, which the parasite then crystallizes so that it won't be poisoned by it. Eventually, however, an infected person can die from cerebral hemorrhages or anemia that are consequences of red cell infection.

Natural products such as quinine, extracted from the cinchona tree, and leaves from the artemisinin shrub were the only options available to treat the infection until World War II, when both Germany and the United States started massive drug discovery programs based on the toll the parasite was having on soldiers − more U.S. soldiers died from malaria in the Pacific than from all enemy fire, Roepe said. The Germans first invented chloroquine (CQ), a synthetic version of quinine, which quickly became the treatment of choice because it was inexpensive − now seven cents a dose − and needs no refrigeration. The drug works by preventing heme crystallization, which destroys the parasite by building up toxic levels of non crystalline heme.

But because of the overuse of chloroquine, isolates of P. falciparum from around the globe have developed genetic mutations that make them resistant to that drug as well as other similar agents. Not all mutations found in all resistant isolates are the same, however. Parasites in different geographic regions have developed unique patterns of mutations in the three genes mentioned above. Now, researchers can tell where a drug resistant parasite comes from depending on the varied mutations in the three different resistance genes, Roepe said. "There are patterns of mutations in these genes that can tell you if the parasite came from Africa
'"/>

Source:Georgetown University Medical Center


Page: 1 2 3 4

Related biology news :

1. Largest computational biology simulation mimics life’s most essential nanomachine
2. Largest study of human interactome reveals a novel way
3. Largest genomic search finds genes that may contribute to autism
4. Inexpensive, mass-produced genes core of synthetic biology advances at UH
5. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
6. Tagging pathogens with synthetic DNA barcodes
7. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
8. Heparin prepared synthetically could replace animal-derived drug
9. Williams College biologist explores photosynthetic apparatus
10. New synthetic self-assembling macromolecules mimic nature
11. Locusts built-in surface analysis ability directs them to fly overland
Post Your Comments:
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... market, reports on the recent success of the Wocket™ smart wallet at ... Wocket smart wallet was named as one of the "11 Hot Products ... Best Products Launched At CES So Far" by Newseveryday.com and "The top ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) ... Wearable Technologies Market and Applications, Opportunities, Industry Analysis, ... 2014-2020" report to their offering. , ... can be worn on the user,s body and ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces it ... Robbins for the 2015 International CES debut of the ... will be at the NXT-ID booth January 6th and ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... an automated literature search tool for the multidisciplinary ... as a free plug-in to Cytoscape 2.1, an ... a visual map of complex biological networks, increasing ... causes of disease. , The Agilent Literature Search ...
... who last year won a Presidential Award, the nation's ... cell research one step closer to reality. , Arinzeh, ... researching the use of stem cells to induce bone ... will not properly heal. She is using adult stem ...
... University in St. Louis have discovered an entirely new ... in plant flowering and DNA methylation, a key chemical ... headed by Craig Pikaard, Ph, D., Washington University professor ... fourth kind of RNA polymerase found only in plants ...
Cached Biology News:Agilent Technologies releases automated literature search tool for biology researchers 2Agilent Technologies releases automated literature search tool for biology researchers 3NJIT Presidential Award winner takes stem cell research another step 2NJIT Presidential Award winner takes stem cell research another step 3New RNA polymerase discovered in plants 2New RNA polymerase discovered in plants 3
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data ... was a record-breaking year across the board for the company. ... Data Platform and our Smart Data solutions, our customers were ... which led to record growth for the company in 2014,” ...
(Date:1/22/2015)... zFlo Motion , a US leader ... exciting product from a new partner. STT-Systems has ... past 15 years, with offerings in the optical-motion capture, 3D ... system (inertial measurement unit), iSen, is opening eyes around the ...
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:12/25/2014)... report “Service Quality Management and Telco Customer Experience Management ... Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and segments ... revenues. , Browse 152 market data tables, 19 ... “Service Quality Management (SQM) and Telco Customer Experience Management ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... 2011 /PRNewswire-iReach/ -- Advanced Technological Education Television (ATETV), ... National Science Foundation , returns with 40 new videos ... is a free Web video series featuring up to ... and employment opportunities. The series debuted in 2009 and ...
... An online library of cellular images freely available ... its one-year anniversary on August 9, 2011 by winning ... website. The Scientist announced the readers, choice ... the judges. The Cell has more than 3,000 searchable ...
... SAN FRANCISCO, Calif., Sept. 1, 2011 Veracyte, Inc., ... molecular cytology, today announced that new data from researchers ... routine use of its Afirma® Gene Expression Classifier for ... (FNA) samples will improve patient care and save the ...
Cached Biology Technology:New Videos Spotlight Science/Technology Careers and Educational Path To Secure Jobs in Them 2Free Online Library of Cell Images Wins 'The Labby' 2New Data Suggest Veracyte's Afirma® Gene Expression Classifier Cost-Effectively Resolves Inconclusive Thyroid Nodule FNA Biopsy Results 2New Data Suggest Veracyte's Afirma® Gene Expression Classifier Cost-Effectively Resolves Inconclusive Thyroid Nodule FNA Biopsy Results 3
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
...
Biology Products: