Navigation Links
Lab research may one day lead to cancer treatment using patient's own immune cells

A new line of developing research is underway that hopes to use a patient's own immune cells to fight cancer. The field, known as adoptive immunotherapy, is a specialty procedure performed in only a handful of institutions, which may one day include University Hospitals Case Medical Center.

Julian A. Kim, M.D., chief of surgical oncology at UH Ireland Cancer Center, has received a $660,000 grant from the National Institutes of Health for a five-year study that hopes to lead to new treatments using a set of immune cells, called T cells, to fight skin cancer (melanoma) and breast cancer. The research project is called "Molecular studies of T cell clones for adoptive therapy."

The pre-clinical trial, which means it will be used only in human tissues in the laboratory at this stage, will focus on identifying and harvesting T cells within the lymph nodes of patients, activating these T cells and growing them in culture in the laboratory over one to two weeks. The T cells are activated with molecular agents called interleukin-2 and anti-CD3 antibody (OKT3).

It is hoped that results from this research could lead to a safety study, called a Phase I study, in humans using this process. This pre-clinical research will help researchers learn how to most effectively select and obtain the T cells for this form of therapy. In future use with humans, the cells would be grown in the cell processing facility located in the Iris S. and Bert L. Wolstein Research Building, which opened in 2003. The activated T cells would be reinfused into the bloodstream of the same patient to train their immune system to fight the cancer.

According to Kim, the Phase I study would involve about 20 patients and would open in about five years. "If these trials prove successful, a similar approach could be developed in patients with other types of cancer as well," said Kim.


'"/>

Source:University Hospitals of Cleveland


Page: 1

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. New research questions basic tenet of neuron function
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 ... and 23andMe , the leading personal genetics company, ... Zipongo can now provide customers with personalized nutrition plans ... and biometrics, but also genetic markers impacting how their ... Zipongo,s personalized food decision support platform uses biometrics such ...
(Date:3/7/2017)... , March 7, 2017   HireVue , ... top global companies identify the best talent, faster, today ... Chief Sales Officer (CSO) and Diana Kucer ... round out a seasoned executive team poised to drive continued ... building on a year of record bookings in 2017. ...
(Date:3/2/2017)... , March 2, 2017 Summary This ... Perrigo and its partnering interests and activities since 2010. ... Read the ... and Alliance since 2010 report provides an in-depth insight into ... sciences companies. On demand company reports are prepared ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... March 24, 2017 Agenus Inc. (NASDAQ: AGEN), ... antibodies and cancer vaccines, today announced participation at the ...  Annual William Blair and Maidstone Life Sciences conference "Cancer ... in New York, NY . Agenus ... 29 at 9:40 am: Robert B. Stein , ...
(Date:3/23/2017)... 23, 2017  Northwest Biotherapeutics (OTCQB: NWBO) (NW ... therapies for solid tumor cancers, today announced that ... it announced last Friday, March 17, 2017. ... investors securities totaling 28,843,692 shares, comprised of 18,843,692 ... shares of Class C Warrants pre-funded at the ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... was recently selected by the Connecticut Technology Council (CTC) as a 2017 Women ... CTC’s thirteenth annual Women of Innovation Awards Dinner. , The dinner recognizes women ...
(Date:3/23/2017)... , March 23, 2017  Agriculture technology company Cool ... financing and note conversion to commercialize its Cool Terra ... focused on developing products that are simultaneously profitable as ... in the last 18 months. This latest round of ... Venture Partners. The company,s primary product, ...
Breaking Biology Technology: