Navigation Links
LIAI scientists make major finding on potential smallpox treatment

Research could lead to treatment that would help stop a smallpox outbreak

Researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have made a major advancement toward protecting society against a smallpox outbreak by identifying an antibody in humans that quickly fights the smallpox virus.

"This is a very important finding because it has the potential to be an effective treatment for smallpox in humans and therefore could help quickly stop a smallpox outbreak," said Mitchell Kronenberg, Ph.D, LIAI President. The finding is contained in a paper entitled "Vaccinia H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice" that was published in the September issue of the Journal of Virology. LIAI scientist Shane Crotty, Ph.D., a viral disease expert, led the team of LIAI scientists which made the finding. Dr. D. Huw Davies and Dr. Phil Felgner of the University of California, Irvine Center for Vaccine Research were also major contributors.

Dr. Crotty and his team have discovered a protein in the smallpox virus ?the H3 protein -- that elicits a particularly strong human antibody response. "Out of the 200 or so proteins contained in the smallpox virus, we found that the H3 protein is a major target for antibodies that kill the virus," he said. No actual smallpox virus was used in the studies in order to avoid any potential danger of transmission.

Dr. Crotty made the findings by studying blood samples from people who had received the smallpox vaccine. "We used new techniques that we developed that made it easier to identify and isolate antibodies from the blood of immunized humans. Then we carefully screened for the antibodies that fight the smallpox virus," he said. The researchers then tested their findings by creating a batch of the anti-H3 protein antibodies, which they injected into mice. "We were able to protect them from a strain of vaccinia pox virus that is very similar to smallpox and which is lethal to mice."

The National Institutes of Health is now funding further research by Dr. Crotty to better understand the molecular processes surrounding the finding. He said one focus of the research will be to fully develop anti-H3 antibodies in the lab that can be given to humans. "We'll be working to further characterize and develop the use of this antibody as a treatment for smallpox," Dr. Crotty said.

The smallpox virus has been the subject of intense research interest worldwide in the last several years, prompted by bioterrorism concerns. The virus was eradicated in the U.S. by 1950 and vaccinations for the general public were ended in 1972. But in the aftermath of 9-11, new concerns have arisen that the smallpox virus could be used as a bioterrorist agent. Disease experts fear that samples of the smallpox virus may have fallen into the hands of terrorists at some point. This concern has led to the creation of worldwide stockpiles of the smallpox vaccine over the last several years.

Kronenberg said that if further study continues to validate the safety and effectiveness of Dr. Crotty's finding, "we may one day see high-quality batches of anti-H3 antibody stockpiled around the world right along side the supplies of smallpox vaccine.

"While we do have a smallpox vaccine, there are concerns because people who are immuno-compromised cannot use the current vaccine," he added, "including infants and the aged." Additionally, if there were a smallpox outbreak, there would be a certain time lapse before all people who have not been inoculated could receive the vaccine. Unlike the vaccine, the antibody would work to provide immediate, although short-term protection, similar to how an antibiotic treats and for a short time protects against a bacterial infection.

"This makes Dr. Crotty's research even more interesting because his findings appear to offer a w ay to successfully treat the virus," Kronenberg said. "This could be very important should people become infected before they have a chance to be vaccinated."


Source:La Jolla Institute for Allergy and Immunology

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:

(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... 2015 Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ... , so that they can be quantitatively analyzed with ... Munich, Germany , October 28-29, 2015. SMI,s Automated ... mobile eye tracking videos created with SMI,s Eye ...
(Date:10/26/2015)... , October 26, 2015 ... --> adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
Breaking Biology Technology: