Navigation Links
'LEGO-Like' building blocks to halt cell growth wins Hebrew University prize

A method for delivery of drugs to targeted cells through the design of specific molecular structures called SIB (Small Integrated Building Blocks) has won a prestigious scientific prize for a Ph.D. student in organic chemistry at the Hebrew University of Jerusalem

Jerusalemite Nir Qvit, 34, will be one of those receiving the Kaye Innovation Award on June 13, during the 69th meeting of the Hebrew university Board of Governors.

Qvit has shown through his research that it is possible to greatly increase drug delivery efficiency by designing specific molecular structures made up of known pharmaceutically effective peptides (small protein molecules) that are attached to tailor-made, geometric-like structures called "scaffolding."

Each scaffold is specifically designed to combine the peptides in such a way that they will form an effective medicinal combination and so that they will bind to the receptors of specific targeted cells. Qvit refers to his process as somewhat analogous to building different kinds of structures through the use of LEGO.

Qvit, a student of Prof. Chaim Gilon of the Department of Organic Chemistry, has shown, for example, that with a particular combination of peptides and scaffold design, it is possible to create a synthetic molecule that will bind to the IGF-1 (insulin-like growth factor-1) receptor. IGF-1 is a protein that plays a critical role in the proliferation of many cancers, including prostate, lung, breast, colon and brain cancers. The binding action of the molecule to the receptor inhibits the activation of the IGF-1 protein in the cells, thus halting the cancerous growth.

Through this process of "combinational chemistry," involving peptides and scaffold design, Qvit says that many different types of molecules can be built that will reach specifically targeted cells, offering hope for treatment of not only cancer, but other diseases as well, without harming healthy cells.


'"/>

Source:The Hebrew University of Jerusalem


Page: 1

Related biology news :

1. Timing is everything: First step in protein building revealed
2. Structure-building cell signals also may influence learning and memory
3. Scientist uses form to explain function of key building blocks of life
4. Mouse study: New muscle-building agent beats all previous ones
5. Insects and mammals share common fat-building pathway, study suggests
6. Jefferson researchers building a better rabies vaccine
7. Anemone genes reveal versatile building blocks for body plans
8. Bacteria could steady buildings against earthquakes
9. Blood sugars manufacture limited by building blocks supply
10. Brainstem blocks pain to protect key behaviors
11. Cigarette smoke blocks cell repair mechanism, University of Florida study shows
Post Your Comments:
(Date:6/24/2015)... 2015 The biologics safety testing market is ... the market include growth of the pharmaceutical and biological ... Over the years, the number of drug approvals in ... the FDA approved 225 drug applications and Health Canada ... Europe accounted for 3,822 of the pharmaceutical ...
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... out of the University of Alberta for those who may have ... medical researchers have found a way to reduce the amount of ... from food the body metabolizes, a key discovery that could lead ... 2 diabetes and heart disease related to obesity. In ...
... A Web site is a better source of information ... to a study of low-income mothers reported in the January ... http://www.jneb.org/) . Led by Kami J. Silk, Ph.D., of ... mothers with nutrition information in different formats. One group ...
... cause of sudden cardiac death even when it isnt overdosed ... chronic pain or drug addiction withdrawal, a new study by ... findings, described in the January 2008 issue of The American ... sudden cardiac deaths in the greater Portland, Ore., metropolitan area ...
Cached Biology News:University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels 2For nutrition info, moms like the Web best 2Methadone even at therapeutic levels can kill 2Methadone even at therapeutic levels can kill 3
(Date:7/6/2015)... June 29, 2015 ... the addition of the "Biotechnology for the ... Biotechnology for the Non-Biotechnologist, ideal for non-Scientists and ... techniques and potential of biotechnology. Ideal ... basic theory, principles, techniques, and potential of biotechnology ...
(Date:7/6/2015)... July 6, 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... agreement with Novella Clinical (Novella), to conduct ... with newly diagnosed glioblastoma. Novella is a full-service, global ... small to mid-sized oncology companies. The ICT-107 phase 3 ... US, Europe and ...
(Date:7/3/2015)... , July 3, 2015 ... voivat hakea verkossa osoitteessa  http://www.openinnovationinscience.at ... Open Innovation in Science" -jatkokoulutusohjelmaan ... Boltzmann Gesellschaftin (LBG) tekemän, kansainvälisiä ... mukaan terveystieteiden kaksi suurinta haastetta ...
(Date:7/3/2015)... , July 3, 2015 ... 22 september 2015 på  http://www.openinnovationinscience.at till ... in Science" som hålls i ... färsk undersökning med internationella forskare och vetenskapsmän ... är hälsovetenskapens två största utmaningar bristen på ...
Breaking Biology Technology:ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3
... Inc. announced that the launch of a new ... of cancer treatments.  BioSpeciFx® is composed of carefully ... biomarker tests that identify critical molecular targets within ... by BioSpeciFx® in combination with Precision,s sophisticated drug ...
... Texas, April 7, 2011 Wound Management Technologies, Inc., ... leader in advanced wound care solutions, today announced that ... care products within key international markets, has received new ... gel products.  In Lebanon, the subsidiary just completed a ...
... Reportlinker.com announces that a new market research report ... Industrial Biotechnology China News 1103 ... government was reported to continue intensifying the demand ... (2011-2015) Plan. This act is expected to help ...
Cached Biology Technology:Precision Therapeutics Announces New Tumor Profiling Product to Augment Utility of ChemoFx® and Further Personalize Cancer Treatment 2WNDM Secures Additional International Sales; $150 K in New Orders for 2011 2WNDM Secures Additional International Sales; $150 K in New Orders for 2011 3Reportlinker Adds Industrial Biotechnology China News 1103 2Reportlinker Adds Industrial Biotechnology China News 1103 3