Navigation Links
Knowledge of dendritic cells branches out

A new type of cell that generates crucial cells of the immune system has been discovered at The Walter and Eliza Hall Institute. With this new knowledge, medical researchers can begin to consider the development of customized immune therapies using this new cell to target specific infections such as HIV, malaria and influenza;certain cancers; and even autoimmune diseases.

Dendritic cells (or "DC" ) are specialised white blood cells that patrol the body, searching for infections. DC seize and then internally break apart any infectiousorganisms that they find. These fragments are then presented on the waving branches or "dendrites" of the DC to activate the immune system's killer T cells. These activated T cells then eliminate the existing infection and resist any future attack by memorizing that infection.

DC also have an important educative role to play in preventing autoimmune diseases, such as type 1 diabetes and Multiple Sclerosis, where the body's immune system mistakes "self " for "foreign " and launches an attack. Since DC are central to many immune responses, they are potential targets for the development of new immune therapies.

Since their discovery in the US in 1975, it has been known that DC, like other white blood cells, develop from stem cells in the bone marrow. Exactly how that process happens has been a mystery ?until now. Using a mouse model, PhD student Shalin Naik, group leader Professor Ken Shortman and a team of colleagues at The Walter and Eliza Hall Institute have discovered the different " precursors " that produce DC. In doing so, they have also determined that the practical operations of DC are more specialized than previously believed. Rather than being generalized "police "within the body, it seems that DC are effectively organized as specialized squads that deal with specific problems ?just as a police force might have different departments to deal with armed robberies, homicides and fraud. These discoveries at W EHI have profoundly altered our understanding of this important aspect of the immune system.

The research received advance online publication on the Nature Immunology website on 7 May 2006.


'"/>

Source:Research Australia


Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Knowledge of infection may prevent spread of herpes virus
3. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
4. Wisconsin scientists grow critical nerve cells
5. Spleen may be source of versatile stem cells
6. Researchers discover way to make cells in the eye sensitive to light
7. Priming embryonic stem cells to fulfill their promise
8. Lack of enzyme turns fat cells into fat burners
9. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
10. Elusive HIV shape change revealed; Key clue to how virus infects cells
11. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... Amgen, will join the faculty of the University of North Carolina Kenan-Flagler ... of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
Breaking Biology Technology: