Navigation Links
Knowledge of dendritic cells branches out

A new type of cell that generates crucial cells of the immune system has been discovered at The Walter and Eliza Hall Institute. With this new knowledge, medical researchers can begin to consider the development of customized immune therapies using this new cell to target specific infections such as HIV, malaria and influenza;certain cancers; and even autoimmune diseases.

Dendritic cells (or "DC" ) are specialised white blood cells that patrol the body, searching for infections. DC seize and then internally break apart any infectiousorganisms that they find. These fragments are then presented on the waving branches or "dendrites" of the DC to activate the immune system's killer T cells. These activated T cells then eliminate the existing infection and resist any future attack by memorizing that infection.

DC also have an important educative role to play in preventing autoimmune diseases, such as type 1 diabetes and Multiple Sclerosis, where the body's immune system mistakes "self " for "foreign " and launches an attack. Since DC are central to many immune responses, they are potential targets for the development of new immune therapies.

Since their discovery in the US in 1975, it has been known that DC, like other white blood cells, develop from stem cells in the bone marrow. Exactly how that process happens has been a mystery ?until now. Using a mouse model, PhD student Shalin Naik, group leader Professor Ken Shortman and a team of colleagues at The Walter and Eliza Hall Institute have discovered the different " precursors " that produce DC. In doing so, they have also determined that the practical operations of DC are more specialized than previously believed. Rather than being generalized "police "within the body, it seems that DC are effectively organized as specialized squads that deal with specific problems ?just as a police force might have different departments to deal with armed robberies, homicides and fraud. These discoveries at W EHI have profoundly altered our understanding of this important aspect of the immune system.

The research received advance online publication on the Nature Immunology website on 7 May 2006.


'"/>

Source:Research Australia


Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Knowledge of infection may prevent spread of herpes virus
3. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
4. Wisconsin scientists grow critical nerve cells
5. Spleen may be source of versatile stem cells
6. Researchers discover way to make cells in the eye sensitive to light
7. Priming embryonic stem cells to fulfill their promise
8. Lack of enzyme turns fat cells into fat burners
9. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
10. Elusive HIV shape change revealed; Key clue to how virus infects cells
11. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... --  ivWatch LLC , a medical device company focused on improving ... of its ISO 13485 Certification, the global standard for medical device ... (ISO®). ... Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it ...
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board ... Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been selected ... member of the winning team for the 2015 Breakthrough Prize in Fundamental physics for ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... and applications consulting for microscopy and surface analysis, Nanoscience Instruments is now ... Analytical offers a broad range of contract analysis services for advanced applications. ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... the healthcare and technology sector at their fourth annual Conference where founders, investors, ... inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health and ...
(Date:10/5/2017)... , ... October 05, 2017 , ... Understanding the microbiome, ... frontiers in human health. Gut Love: You Are My Future, the newest exhibit on ... perspective as it explores the human condition through the lens of the gut microbiome. ...
Breaking Biology Technology: