Navigation Links
Knockout Mouse Project

Children's Hospital & Research Center Oakland is leading one of two teams in an international effort to produce thousands of genetically altered mice for a study to understand the role of individual genes in human health. Other members of the team represent the School of Veterinary Science at the University of California, Davis and the Wellcome Trust Sanger Institute in Hinxton, England. The National Institutes of Health (NIH), announced the selection of the hospital's research institute for the Knockout Mouse Project (KOMP) on September 7, 2006.

The $50 million initiative funded by the NIH is intended to help researchers explore the functions of 10,000 mouse genes. Humans and mice share the same characteristics for most of the 10,000 mouse genes identified for this study. Researchers hope to catalogue and confirm the functions of these genes and identify the disease consequences if these genes are defective. Since human and mice genes are similar, it is hoped that by inactivating mouse genes, one-by-one, the altered mice will yield clues about the function of human genes and their similar roles in human diseases.

"The process is a long one, but the rewards are immeasurable," said Pieter de Jong, Ph.D., Children's Hospital Oakland Research Institute scientist and principle investigator for KOMP. "We're at the forefront of understanding the pathology of human genes. By knocking out each gene one-by-one, we will be able to create a central resource for researchers and scientists to use and study," said Dr. de Jong.

Children's Hospital Oakland Research Institute has a recombinant DNA library with more than 30 million DNA samples that are used in research programs around the world. The research institute's DNA library has become a major resource for ongoing global research in the genetics of human diseases. The recombinant DNA library is, for example, being used in Oakland to investigate the genetic differences that make certain peopl
'"/>

Source:Children's Hospital & Research Center at Oakland


Page: 1 2

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Mouse with designer liver has enhanced glucose tolerance, insulin response
6. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
7. Mouse genome much more complex than expected
8. Mouse study: New muscle-building agent beats all previous ones
9. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
10. Mouse to man: The story of chromosomes
11. Mouse mimics chronic leukemia, will aid drug development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Knockout Mouse Project

(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... amounts, it can make teeth stronger and aid in the ... can be a killer a carcinogen that causes bone, ... additive in most American communities, drinking water and an ingredient ... Determining the level of fluoride, be it in water, consumer ...
... and heart attacks have been found to share common genetic ... test on developing the risk of the diseases even at ... the University of Bologna who coordinated the study published in ... test is now ready. "They are already selling it in ...
... at Virginia Tech have discovered some of the key ... inflammatory bowel disease. The results, which help researchers move ... drugs to treat inflammatory and immune-mediated diseases, are reported ... the journal Mucosal Immunology from the Nature ...
Cached Biology News:Researcher develops accurate method for detecting dangerous fluoride 2Researcher develops accurate method for detecting dangerous fluoride 3Researcher develops accurate method for detecting dangerous fluoride 4Medicine: Alzheimer's and heart attacks share the same genes 2Medicine: Alzheimer's and heart attacks share the same genes 3Immune system changes linked to inflammatory bowel disease revealed 2Immune system changes linked to inflammatory bowel disease revealed 3
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... biomaterial market will grow moderately through 2023 as the ... growing awareness of dental biomaterials all spur procedure volumes. ... as China and ... dental procedures within reach for a larger proportion of ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... 3 tropical storm that struck the low-lying and heavily populated coastline ... of the U.S. Department of Agriculture (USDA) began producing a series ... to accompany its commodity intelligence reports. , ... Redlands, ...
... Bio-Pharma Solutions, Inc.,(ABS), a global provider of ... is pleased to announce that Nandini,Hadker, an ... been promoted to,Executive Director and will oversee ... has been appointed,President & CEO of the ...
... Inc., an,acute care specialty pharmaceutical company, today announced the,appointment ... a key senior,executive to the company,s management team. Gary ... biopharmaceutical executive with more than,30 years of experience. Dr. ... the founder and past Chairman and CEO of QRx ...
Cached Biology Technology:Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 2Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 3Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 2Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 3Pacira Pharmaceuticals, Inc. Adds Board Member and Key Senior Management 2
BD BioCoat Osteologic Coverslips that have been sterilized by ETO gas. Coating : Osteologic&trade ,Thickness : 0.16 mm ,Diameter : 12.7 mm ,Gridded : No ...
...
... bis (3-ethylbenzthiazoline-6-sulfonic Acid) Clear to very ... and H 2 O 2 in a ... substrate that is soluble, safe, convenient and has ... develops intense blue-green color that can be measured ...
...
Biology Products: