Navigation Links
Killing the messenger RNA -- But which one?

ne species of microRNA against data banks of known gene sequences, the scientists identified two different groups of about 80 genes each likely to be targeted by the two versions of the molecule. They then selected three genes from each group for a closer look, testing to see whether their expression was in fact altered, up or down, by the microRNAs. It was.

Then they chose one potentially affected gene at random to explore the ramifications of microRNA editing in depth. As it turned out, the gene they selected, known as PRPS1, codes for an essential enzyme involved in synthesizing uric acid. If levels of the enzyme are poorly regulated, a number of health problems can arise. For example, too-high levels of the enzyme can cause uric acid levels to rise in the blood, triggering painful episodes of gout. Similarly, in the brain, excess uric acid can damage sensory neurons and cause deafness.

Working with a strain of transgenic mice unable to perform RNA editing and normal control mice, the researchers found that a complete lack of the edited version of the microRNA in question had the effect of driving production of the PRPS1 enzyme to about double its normal levels. This, in turn, drove levels of uric acid up to about two times what they should be.

"This confirmed that our original computer prediction of differential targeting by unedited and edited microRNAs of different sets of genes is likely to be correct," Nishikura says. "And in at least the case of the one gene we investigated, this differential has physiological consequences seen in the elevated uric acid levels."

Given the fact that the PRPS1 gene was randomly selected for investigation by the researchers, the findings suggest that a number of other as-yet unidentified disorders may also have their roots in this newly identified microRNA editing process.
'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Duke Experiments Boost Radiations Cancer-Killing Effects
2. Killing brain tumors from within: A Trojan horse approach
3. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
4. Second messenger NAADP shows fast, dose-related impact on satiety cycle
5. Notorious cancer gene may work by destroying messenger
6. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
7. Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals
8. Bacteria which sense the Earths magnetic field
9. Researchers discover which organs in Antarctic fish produce antifreeze
10. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
11. Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Killing the messenger RNA But which one

(Date:9/30/2014)... environmental effects of moorland burning is published today in ... the aim of relieving tensions on both sides of ... (Effects of Moorland Burning on the Ecohydrology of River ... which is practised predominantly to support red grouse populations ... hydrology, peat chemistry and physical properties, river water chemistry ...
(Date:9/30/2014)... captured the popular attention of both children and aquarium ... sold as dehydrated eggs, these tiny brine shrimp readily ... tank of salt water. , Physicists, though, are ... shrimp vertically migrate in large groups in response to ... night and retreating deeper during the day. , Two ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
Breaking Biology News(10 mins):Grouse moor burning causes widespread environmental changes 2Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... 20, 2012   Cell Therapeutics, Inc. ("CTI") (NASDAQ and ... European Medicines Agency,s ("EMA") Committee for Medicinal Products for ... on CTI,s Marketing Authorization Application ("MAA") for Pixuvri in ... with the CHMP on the Summary of Product Characteristics ...
... of scientists has found one of the rarest and least ... was believed to be extinct or on the verge of ... of Primatology , confirms the continued existence of this endangered ... it was previously not known to exist. Miller,s Grizzled ...
... flow channels offer a chemically unique environment, which at first ... in the crust of the earth, through which water flows, ... And yet it is precisely this extreme environment, where ... root of all life: The multiplication of biomolecules (reproduction) and ...
Cached Biology News:Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February 2Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February 3'Extinct' monkey rediscovered in Borneo by new expedition 2Avalanche of reactions at the origin of life 2Avalanche of reactions at the origin of life 3
(Date:10/1/2014)... PHILADELPHIA , October 1, 2014 ... plans to software invited to engage around the theme, ... 29-30     Elsevier ... information products and services, will host a gathering of ... discuss issues and trends impacting healthcare today and in ...
(Date:9/30/2014)... 30, 2014 Applying a well-known optical phenomenon ... Harvard University has demonstrated the ability to "paint" ... that holds promise for making future, flexible electronic ... sides of next-gen rocket ships and spacecraft with ... through oil in water, it becomes iridescent, revealing ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of ... an international research team led by Alejandro Briseno ... a major step in developing long-sought polymer architecture ... for use in electronic devices. , Briseno, ... and others at Stanford University and Dresden University ...
(Date:9/30/2014)... 2014 Report Details Biosimilar drugs ... revenues Do you want to find sales potentials ... predictions for those biological drugs from 2014, helping ... financial data, R&D trends, opportunities and selling prospects. ... to 2024 at overall world market, therapeutic class, ...
Breaking Biology Technology:Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Taking thin films to the extreme 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... all over the globe. Most have a lot of ... about their relevant experiences and capabilities with upfront personalities. ... what is missing is the proof about who really ... management the staff and their true particulars. This information ...
... her series of entrepreneurial profiles, this week Teresa reviews ... was published by O'Reilly Press in 2004. , ,Nerds ... good thing. , ,The first essay in Hackers & ... junior high school cafeteria, mapping out lunch tables according to ...
... Children's Hospital announced on Tuesday that they have ... purchase the information system CardioIMS. The system will be ... which addresses the needs of children and adults with ... an in-depth study of the Center's administrative and clinical ...
Cached Biology Technology:Whats Hush-Hush Marketing? 2Whats Hush-Hush Marketing? 3Hackers & Painters: Big Ideas from the Computer Age 2Hackers & Painters: Big Ideas from the Computer Age 3Hackers & Painters: Big Ideas from the Computer Age 4Hackers & Painters: Big Ideas from the Computer Age 5Children's Hospital chooses Camtronics for cardiology IT system 2
96 Well Plate UB, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
... Incubated Console Orbital Shakers combine high ... unequalled programming power. The patented ... the unit to run with heavy ... filtration system reduces contamination. The ...
...
... combine high durability and capacity with ... use. The patented triple-counterbalanced heavy-duty mechanism ... run at high speed with heavy, ... range is delivered with tight uniformity ...
Biology Products: