Navigation Links
'Killer' B cells provide new link in the evolution of immunity

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered a unique evolutionary link between the most primitive innate form of immune defense, which has survived in fish, to the more advanced, adaptive immune response present in humans and other mammals.

The finding, which appears in the online version of the October issue of Nature Immunology, represents an evolutionary step for the mammalian immune system and offers a potential new strategy for developing much-needed fish vaccines.

In the adaptive immune system in mammals, B cells produce antibodies to fight infection. In the more-primitive innate immunity in fish, the scientists found that B cells take part in a process known as phagocytosis, by which immune system cells ingest foreign particles and microbes.

In modern mammals, the B cell is a highly adapted part of the immune system chiefly responsible for, among other things, the creation of antibodies that tag foreign particles and microbes for destruction.

"When examining fish B cells we see them actively attacking and eating foreign bodies, which is a behavior that, according to the current dogma, just shouldn't happen in B cells," said J. Oriol Sunyer, a professor in Penn Vet's Department of Pathobiology and leader of the research team.

The researchers determined that these attack B cells account for more than 30-40 percent of all immune cells in fish, whereas phagocytic cells make up only a small portion of the total number of immune cells in mammals.

According to Sunyer, the findings are important for not only understanding the evolution and function of immune cells in fish but also may point to novel roles of B cells in mammals. Their findings also have an agricultural implication. Vaccines currently given to farmed salmon, for example, appeal to the fish's adaptive immune response, which this research now shows to be a small part of the overall fish immune system.
'"/>

Source:National Science Foundation


Page: 1 2

Related biology news :

1. Killer B cells demonstrate evolutionary link between fish and mammal immune systems
2. Wisconsin scientists grow critical nerve cells
3. Spleen may be source of versatile stem cells
4. Researchers discover way to make cells in the eye sensitive to light
5. Priming embryonic stem cells to fulfill their promise
6. Lack of enzyme turns fat cells into fat burners
7. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
8. Elusive HIV shape change revealed; Key clue to how virus infects cells
9. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
10. Enzyme allows B cells to resist death, leading to leukemia
11. Scientists rid stem cell culture of key animal cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Killer cells provide new link the evolution immunity

(Date:9/17/2014)... and their environmental impact recently scored a major win. ... on the bags, and Governor Jerry Brown is expected ... not yielding without a fight, according to an article ... newsmagazine of the American Chemical Society. , Alexander Tullo, ... campaign logged its first small victory in 1990 when ...
(Date:9/17/2014)... at IMIM (Hospital del Mar Medical Research Institute) and ... published a study in eLife showing that ... the evolution of new proteins, some of which could ... produce proteins from the instructions found in an RNA ... RNA containing information for the synthesis of proteins, meaning ...
(Date:9/17/2014)... the Catalan Institute of Oncology-Bellvitge Biomedical Research Institute ... genes differentially expressed in normal accompanying cells in ... used to classify colorectal tumors, predict the evolution ... decisions to prevent relapses. , Biomarkers ... in our population considering both sexes. About 30,000 ...
Breaking Biology News(10 mins):Parts of genome without a known function may play a key role in the birth of new proteins 2Five genes to predict colorectal cancer relapses 2
... outbreak of avian or "bird flu" lingers, health officials recognize ... the virus already have developed resistance to the current roster ... Diego scientists - with the help of resources at the ... - have isolated more than two dozen promising and novel ...
... University have found that quantum dot nanoparticles can penetrate ... into potential workplace concerns for healthcare workers or individuals ... research on potential biomedical applications of the tiny nanoparticles. ... different sizes, shapes and surface coatings do not penetrate ...
... German . , Metabolomics aims to determine the totality ... The exponents of bioinformatics analyzed data collected in the framework ... In each case, a subgroup of the animals was treated ... were quantitatively determined in a blood plasma sample of a ...
Cached Biology News:UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 2UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 3UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 4Study shows quantum dots can penetrate skin through minor abrasions 2Healthy or diseased? 2
(Date:9/17/2014)... The global consumption of squalene / squalane is ... natural skin-identical chemical that finds applications in various end user ... and in other applications like high grade lubrication, and fiber ... major players and is regionally segregated. Sophim ( France ... Ltd. ( Japan ), SeaDragon Marine Oils Ltd. ...
(Date:9/17/2014)... Md. (PRWEB) September 17, 2014 ... Comprehensive Two-Dimensional Liquid Chromatograph (2D-LC), which offers ... complex sample matrices. The system provides a ... sample analytes, which is beneficial to scientists ... extracts, and natural products. , Comprehensive 2D-LC ...
(Date:9/17/2014)... Pa. , Sept. 17, 2014 BioClinica®, ... and eClinical Solutions, today announced three of its experts ... for Clinical Data Management to be held September ... Nevada . The Company also announced the innovative ... raise overall quality in clinical trials acquired earlier this ...
(Date:9/17/2014)... Sept. 17, 2014 Hussey Copper , ... 29 antimicrobial copper, announces Gilmour Academy Ice Arena,s ... first EPA-registered antimicrobial solid touch surface to help protect ... reasonably priced surface that kills greater than 99.9% of ... exposure. 1 , ...
Breaking Biology Technology:Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 2Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 3Shimadzu’s New Nexera-e Two Dimensional Comprehensive Liquid Chromatograph Empowers Laboratories to Separate Even the Most Complex Mixtures 2BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3
... Spherix Incorporated (NASDAQ: SPEX ) – ... syndrome and atherosclerosis, and provider of technical and regulatory ... today announced that it has entered into definitive agreements ... stock and warrants to purchase shares of its common ...
... +49(0)69-2222-34066 France: +33(0)1-70-48-01-63 U.K.: +44(0)20-7660-0009 ... is 5634610; to view the webcast, log onto: ... March 13, 2012 - Annual press conference in Goettingen, Germany ... Germany April 24, 2012 - Publication of first-quarter ...
... A relatively fast, easy and inexpensive technique for ... self-assemble into one-, two- and even three-dimensional macroscopic ... researchers with the U.S. Department of Energy (DOE),s ... should enable more effective use of nanorods in ...
Cached Biology Technology:Spherix Announces Registered Direct Offering of $1.15 Million 2Spherix Announces Registered Direct Offering of $1.15 Million 3Preliminary Figures for 2011: Sartorius Grows at Double-Digit Rates and Boosts Operating Earnings by More Than 30% 2Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks 2Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks 3Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks 4
MDMA Mouse Monoclonal Antibody (Clone 3G8)...
Mouse anti-hepatitis delta virus Class: Antibody Product Group: Bacterial and Viral Antigen...
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
Goat polyclonal to PPP2R5D Immunogen: Peptide with sequence KRAEEFLTASQEAL, from C Terminus of the protein sequence according to NP_006236...
Biology Products: