Navigation Links
Key to acute lung injury lies in Ang2 protein

Acute lung injury caused by cell death, high and potentially toxic concentrations of oxygen (hyperoxia), and the resulting excess fluid in the lungs (pulmonary edema), may be controlled by modulating levels of the angiopoietin2 (Ang2) protein, researchers at Yale School of Medicine report in the November 5 online issue of Nature Medicine.

The study, which was completed in the laboratory of senior author Jack Elias, M.D., the Waldemar Von Zedtwitz Professor and chair of internal medicine at Yale, looked at the response to hyperoxic acute lung injury (HALI), first in mice and then in human adults and babies. The team found that mice in which the Ang2 gene was genetically eliminated or silenced lived longer and had evidence of decreased lung injury compared to mice in which the gene and protein were intact.

Levels of the Ang2 protein were then measured in the blood and lung fluid of adult patients and babies with acute lung damage and pulmonary edema. The team found that levels of Ang2, which is known to increase leaks in blood vessels and causes the death of endothelial cells that line the blood vessels, were higher in adult patients with acute lung injury and in babies born with respiratory distress syndrome who either went on to develop bronchopulmonary dysplasia or died.

"Mice without Ang2 seemed to be protected against hyperoxia," said first author Vineet Bhandari, M.D., assistant professor of pediatrics at Yale School of Medicine. "This protein seems to be a mediator of cell death in the settings of high oxygen concentrations in the lung causing acute lung injury and pulmonary edema."

Bhandari said the study is an example of true bench-to-bedside translational research. "All the work was initially done on mice in which we found that the Ang2 protein was involved in HALI," said Bhandari. "We also defined how the protein creates lung injury and then we showed its clinical relevance by documenting its presence in human patients w
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Stem cells bring fast direct improvement, without differentiation, in acute renal failure
2. UNC launches study of liver injury caused by drugs
3. Brain-injury rehabilitation depends on acetylcholine circuitry
4. Stem cell treatment improves mobility after spinal cord injury
5. Combination therapy leads to partial recovery from spinal cord injury in rats
6. Study reveals genomics of inflammation from severe injury
7. Clinical trial to test stem cell approach for children with brain injury
8. Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
9. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
10. Cincinnati surgeons report new treatment for often-fatal injury
11. Spinal cord bridge bypasses injury to restore mobility
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key acute lung injury lies Ang2 protein

(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   LaunchKey ... built for the post-password and Internet of Things era, ... seed funding. The venture round was led by Metamorphic ... Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has ...
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the travel experience ... borders. Over the past decade, ePassports, biometric readers, and ... process through border control via eGates and Automated Passport ... seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... (Santa Barbara, Calif.) Scientists at UC Santa Barbara have ... affect giant kelp forest ecosystems at unprecedented spatial and temporal ... divers with satellite images of giant kelp canopies taken by ... the feature article of the May 16 issue of ...
... the University of Alberta have taken an important step in ... have implications for medical care and both the pharmaceutical and ... impact journal Nature Structural & Molecular Biology , Andrew ... step of the immune response of bacterial cells. Scientists had ...
... of a prolonged tropical storm in the Panama Canal ... Research Institute and research hydrologist at the U.S. Geological ... organized four flights over the watershed to create a ... of heavy rain inundated the Panama Canal watershed between ...
Cached Biology News:UCSB scientists track environmental influences on giant kelp with help from satellite data 2UCSB scientists track environmental influences on giant kelp with help from satellite data 3Understanding a bacterial immune system 1 step at a time 2Landslides: How rainfall dried up Panama's drinking water 2Landslides: How rainfall dried up Panama's drinking water 3
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
(Date:12/24/2014)... Wash. , Dec. 24, 2014   BioLife Solutions , ... and marketer of proprietary clinical grade hypothermic storage ... shipping products for cells and tissues  ("BioLife" or the ... Meeting of Stockholders on May 4, 2015 (the "Annual Meeting"). ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... is designed to introduce cutting edge communication technology, ... of platform upgrades. This webinar series demonstrates online ... quest to leverage web conferencing’s most innovative and ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George A. ... Reproductive Medicine (ASRM), a leading professional organization committed to advancing ... role as treasurer, Dr. Hill also fills a seat on ... the mission of ASRM. , Dr. Hill has actively ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
Request Info...
... Star strains are high-performance ... improved protein yield in ... (Figure 1). Because the ... mRNA more rapidly than ...
... small volume applications, including pediatric, neonatal, geriatric, general adult, veterinary and experimental animals. Automatic Calibration with ... ... ... ...
X-Gal (5-Bromo-4-Chloro-3-Indoyl-beta -D-Galactopyranoside)...
Biology Products: