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Key mechanism in genetic inheritance during cell division identified

authors say that ring formation is a complicated way to construct a microtubule binding structure, a microtubule binding ring might be uniquely suited to fulfill the functions of the Dam1 complex. In comparison with the purified Dam1, the Dam1 mutants produced partially formed rings that reduced microtubule binding.

"Because the stability of a microtubule is thought to be largely governed by the lateral interactions between adjacent protofilaments," the authors note, "rings that bind orthogonally to the microtubule axis are not only expected to strengthen interprotofilament interactions, but to also prevent protofilament peeling, which in turn would encourage further growth.

Furthermore, the Berkeley researchers showed that binding between the ring and the microtubule is mediated by flexible domains, and is largely electrostatic in nature. This could allow for lateral sliding or diffusion of Dam1 rings along microtubules. Analysis of the Dam1 rings after disassembly of microtubules, revealed an accumulation of rings at the ends of the microtubule, suggesting that the rings do not disassemble but slide back as the microtubule protofilaments peel away from the ends.

Says Nogales, "That the rings remain attached to the microtubule end as it depolymerizes, is a most ingenious mechanism to move chromosome to the two daughter cells during anaphase, without even requiring energy. This is great finding!"


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Source:Eurekalert


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