Navigation Links
Key mechanism in genetic inheritance during cell division identified

A key mechanism in the passing of genetic material from a parent cell to daughter cells appears to have been identified by a team of Berkeley researchers. Their study may explain how a complex of proteins, called kinetochores, can recognize and stay attached to microtubules, hollow fibers in the walls of biological cells that are responsible for the faithful segregation of chromosomes during cell division.

"In test tube experiments, we've found that the kinetochore proteins form rings around the microtubules and this ring formation promotes microtubule assembly, stabilizes against disassembly, and promotes bundling," says Eva Nogales, a biophysicist who holds joint appointments with the Lawrence Berkeley National Laboratory (Berkeley Lab), the University of California at Berkeley, and the Howard Hughes Medical Institute (HHMI). "If ring formation takes place in vivo, it could be the mechanism by which chromosomes are kept segregated during mitosis."


Nogales is one of the co-authors of a paper reporting the results of this research which appears in the January 21, 2005 issue of the journal Molecular Cell. Other authors of the Molecular Cell paper were Georjana Barnes, David Drubin and Stefan Westermann, with UC Berkeley's Department of Molecular and Cell Biology, who were the lead investigators on this work, plus Agustin Avila-Sakar and Hong-Wei Wang, with Berkeley Lab, and Hanspeter Niederstrasser and Jonathan Wong with UC Berkeley.

Says Barnes, "Mistakes in chromosome segregation during mitosis contribute to cancer and birth defects. From various genetic experiments we know that the activity of a 10-protein complex of kinetochores, called Dam1, is responsible for the faithful segregation of chromosomes during mitosis. While we don't know at this time that ring formation occurs in vivo, we do see in our in vitro tests that Dam1 ring formation strengthens the microtubules."

Thousands of microtubule fibers are woven togethe
'"/>

Source:Eurekalert


Page: 1 2 3

Related biology news :

1. A new mechanism of regulating RNA degradation
2. Plants, animals share molecular growth mechanisms
3. PET/MRI scans may help unravel mechanisms of prenatal drug damage
4. Researchers discover molecular mechanism that desensitizes us to cold
5. Chemists identify immune system mechanism for methamphetamine binges
6. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
7. Mouse gene shows new mechanism behind cardiac infarction in man
8. UCSD research reveals mechanism involved with type of fatal epilepsy
9. Ancient immune defense mechanism is no match for HIV-1
10. Malaria mechanism revealed
11. Researchers discover mechanism for multiplying adult stem cells
Post Your Comments:
(Date:7/24/2014)... is available in German . ... 300 million asthma sufferers worldwide, a further 600 million ... of the global population contending with allergic rhinitis (allergic ... also affect other organs and parts of the body ... intestine (in the form of inflammatory bowel diseases such ...
(Date:7/24/2014)... is available in German . ... recognize and respond to threats to health, and to ... understanding of the mechanism underlying immunologic memory, however, has ... converged to support the hypothesis that the persistence of ... with stem-cell-like potential. Until now, there was no conclusive ...
(Date:7/23/2014)... of identical twins has found that early reading skill ... the journal Child Development , was conducted by ... London. , "Since reading is an ability that can ... according to Stuart J. Ritchie, research fellow in psychology ... "Early remediation of reading problems might aid not only ...
Breaking Biology News(10 mins):New drugs to combat asthma and the like 2New drugs to combat asthma and the like 3Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3Stronger early reading skills predict higher intelligence later 2
... (LOS ANGELES, CA) -- The Disability Rights Legal Center ... civil rights of people with disabilities, has recognized Ossur, ... non-invasive orthopaedic products and services, with the Charles D. ... of Prosthetics for Ossur Americas, accepted the award on ...
... soft drink is 20 ounces and contains 17 teaspoons of ... fruit drinks are more erosive than hydrochloric or sulfuric acidwhich ... acids found in soda and citrus juice promote tooth erosion, ... the enamel. Once tooth enamel is lost, it,s gone forever. ...
... INDIANAPOLIS Although its been over a decade since ... the blood repairing and replacing the cells that line ... EPCs are now being studied as biomarkers to assess ... agents for vascular regeneration. Researchers from ...
Cached Biology News:Disability Rights Legal Center honors Ossur 2Drink brewed tea to avoid tooth erosion 2Understanding how oxidative stress impairs endothelial progenitor cell function 2
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... Yushan Yan, Distinguished Professor of Engineering at the ... nanomaterials to solve problems in energy engineering, environmental ... focused on zeolites, porous rock with a well-defined, ... size is so precisely decided that zeolites can ... fraction of an angstrom (one-tenth of a nanometer), ...
(Date:7/24/2014)... Research and Markets has announced ... Analytical Instruments Market 2014-2018" report to their offering. ... Genomics is the study of the gene and its ... and functions of proteomes or sets of proteins by ... involves the mapping of genes and DNA sequencing to ...
(Date:7/24/2014)... BRIDGEWATER, N.J. , July 24, 2014 /PRNewswire/ ... focused on developing and commercializing therapeutic products for ... disease, today announces receipt of notice on July ... that the NYSE-MKT has accepted the CorMedix plan ... the NYSE-MKT. As a result, the NYSE-MKT is ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2University of Delaware researcher describes new approach for creating organic zeolites 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3
... , SAN DIEGO, June 8 , , ... 51 speakers and panelists discussing life sciences and the business relationships ... WHAT: , CALAsia is an international 2-day forum that ... and the Asia Pacific region to identify, explore, and further trans-Pacific ...
... on Testing OVAR Effectiveness , , PITTSBURGH, June ... ), manufacturers of noninvasive medical evaluation equipment used ... disorders, said today that the University of Michigan ... has purchased and installed its I-Portal(R) NOTC (Neuro-Otologic Test ...
... 8 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NYSE Amex: SVA ... that it,begins the production of a vaccine against influenza A (H1N1) ... to the company on June 8, 2009. , ... ,In,the midst of a global outbreak and transmission of H1N1, our ...
Cached Biology Technology:BIOCOM's Inaugural CALAsia Forum 'Bridging the Pacific' 2University of Michigan Installs Neuro Kinetics' I-Portal(R) NOTC System 2University of Michigan Installs Neuro Kinetics' I-Portal(R) NOTC System 3Sinovac Begins the Production of Influenza A (H1N1) Vaccine 2Sinovac Begins the Production of Influenza A (H1N1) Vaccine 3
... high experimental throughput, minimum input of ... 4 up to 16 culture vessels ... users with proven fermentation results when ... fungi or any other microbial application. ...
... Experion system, 100-120 and 220-240 V, is ... steps of gel-based electrophoresis, including some data ... is used for protein analysis (it does ... RNA analysis). The system includes the electrophoresis ...
... in the submicron range are part of ... and control of particle size is important ... can reliably detect the component populations in ... Particle Size Analyzer uses Photon Correlation Spectroscopy ...
... Binding: High, 400 ng IgG/cm 2 ... Interaction: Hydrophobic/Ionic , Performance Certified: Well-to-Well, CV ... Maximum Well Volume: 360 µl , Packaging: ... ,Features, Special optically clear polystyrene formulation , ...
Biology Products: