Navigation Links
Key gene controlling kidney development found

A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital. Differentiation is the process by which a progenitor (unspecialized) cell develops characteristics specific to its job in the body.

The kidney stem cells, called mesenchymal blastemal cells, are the source of cells triggered by chemical signals to differentiate into nephrons--the structures in the kidney that cleanse the blood of waste. The nephrons later become attached to ducts--tubes that collect the filtered blood as urine and direct it to the bladder. The St. Jude team showed that Six2 works by preventing some of the precursor cells from responding to these signals. This ensures there will be a continual source of undifferentiated stem cells available to maintain the growth of the kidney.

"Our work shows that Six2 is critical to preventing the developing kidney from running out of stem cells and collapsing into a mass of underdeveloped tissue," said Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology Department. Oliver is senior author of a report on this finding that appears in the online issue of The EMBO Journal.

"Our discovery of Six2's role in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project.

The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nephrons that in turn produced a useless mass of tissue. Furthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depl eting the population of stem cells that could give rise to differentiated cells needed to form the kidney.

The researchers also found that Six2 works by suppressing a cascade of genetic interactions normally triggered by a gene called Wnt4, which usually drives the normal development of kidneys.

Source:St. Jude Children's Research Hospital

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Key gene controlling eye lens development identified
7. Electronic chip, interacting with the brain, modifies pathways for controlling movement
8. Edge density key to controlling gypsy moth spread
9. Bioartificial kidney under study at MCG
10. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
11. NASA links nanobacteria to kidney stones and other diseases

Post Your Comments:

(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
(Date:11/16/2015)... Nov 16, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced expansion of its TDDI product ... touch controller and display driver integration (TDDI) solutions ... These new TDDI products add to the previously-announced ... TD4302 (WQHD resolution), and TD4322 (FHD resolution) solutions. ...
(Date:11/12/2015)... Mass. , Nov. 12, 2015  Arxspan ... Institute of MIT and Harvard for use of ... discovery information management tools. The partnership will support ... both biological and chemical research information internally and ... will be used for managing the Institute,s electronic ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... PHILADELPIA, PA (PRWEB) , ... November 24, 2015 , ... ... young entrepreneurs at competitive events in five states to develop and pitch their BIG ... student projects from each state are competing for votes to win the title of ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
(Date:11/24/2015)... Telbec/ - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ... Laurin , President and Chief Executive Officer of ProMetic, will ... 27 th Annual Healthcare Conference to be held at ... st , at 8.50am (ET) and ProMetic,s management ... The presentation will be available live via a webcast accessible ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Whitehouse Laboratories ... Laboratory. The new stand-alone facility will be strictly dedicated to basic USP 61, ... and existing clients the chance to have complete chemistry and micro testing performed by ...
Breaking Biology Technology: