Navigation Links
Key gene controlling eye lens development identified

hickening, an initial critical step in lens formation.

"Our discovery helps to better unravel the regulatory pathway that controls normal lens formation," said the paper's senior author, Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology department. "Specifically, it puts the Six3 gene at the top of the genetic cascade that controls the development of the lens. Understanding the early steps leading to lens formation will help us determine what goes wrong in disorders in which the lens does not form, or forms abnormally. That kind of information is often the first step in designing both preventive and treatment strategies for congenital diseases."

The St. Jude team further showed that the proteins coded for by Six3 are present in the PLE before those coded by Pax6. This was evidence that production of Pax6 proteins in that region of the head starts after Six3 proteins are made, further supporting the idea that the Six3 gene controls the Pax6 gene. The researchers also demonstrated that the Six3 protein directly controls the expression of the Pax6 gene by binding to some of the DNA regions that regulate Pax6 activity.

"Our work confirms the early and vital role Six3 plays in the overall development of the eye, and gives us important insights into the interplay of genes during this time," said Wei Liu, Ph.D., a postdoctoral fellow in Oliver's laboratory. Lui is first author of the paper.
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Electronic chip, interacting with the brain, modifies pathways for controlling movement
7. Edge density key to controlling gypsy moth spread
8. Key gene controlling kidney development found
9. A much-needed shot in the arm for HIV vaccine development
10. Clam embryo study shows pollutant mixture adversely affects nerve cell development
11. Zebrafish may hold key to understanding human nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key gene controlling eye lens development identified

(Date:5/22/2013)... Trial (NLST) investigators also conclude that the 20 ... computed tomography (LDCT) versus chest X-ray (CXR) screening ... achievable at experienced screening centers in the United ... share with their patients about the benefits and ... publication in the New England Journal of ...
(Date:5/22/2013)... a major new effort to educate the public and ... with clean water that looms ahead in the 21st ... the current edition of Chemical & Engineering News ... (ACS), the world,s largest scientific society. , Bassam Z. ... Schnoor, Ph.D., explain that shortages of reliable supplies of ...
(Date:5/22/2013)... environmental and human health effects from disposal of ... led scientists to recommend stronger government policies to ... battery materials. That,s the conclusion of a new ... & Technology . , Oladele A. Ogunseitan and ... mainstays for powering everything from smart phones to ...
Breaking Biology News(10 mins):NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 2NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 3
... Those vegetables you had for dinner may have ... the one that helps you fight disease. Scientists from ... (Berkeley Lab) and the Netherland,s Wageningen University found that ... to defend themselves against pathogens, much the way mammals ...
... Academy of Sciences has elected James Birchler, Curators, Professor ... & Science, as a member. Birchler will be inducted ... in Washington, D.C. The National Academy of Sciences ... engaged in scientific and engineering research, dedicated to furthering ...
... An international team of researchers co-led by a University ... pathogens -- one that threatens global wheat supplies and another ... future source for biofuel. The sequencing of the ... ) and poplar leaf rust pathogen ( Melampsora larici-populina ) ...
Cached Biology News:It takes a community of soil microbes to protect plants from disease 2It takes a community of soil microbes to protect plants from disease 3MU professor elected to membership in National Academy of Sciences 2MU professor elected to membership in National Academy of Sciences 3Scientists sequence genomes of 2 major threats to American food and fuel 2
(Date:5/22/2013)... May 22, 2013 Alton Housing Authority was ... 15, 2013 said that their presence has already caused ... bug sufferers avoid such big spending, My Cleaning Products shared ... , It was said in the report that to clear ... related. Apart from that, its employees also attended a mandatory ...
(Date:5/22/2013)... A recent study from researchers in Tasmania ... those who took probiotics were able to run for an ... that in extreme heat conditions, probiotics were able to improve ... treatment explains what this new discovery means for those ... condition. , While researchers tote the benefits of probiotics ...
(Date:5/22/2013)... May 22, 2013  Moderna Therapeutics, the pioneering company ... to enable the in vivo production of ... will join Moderna in early July as ... is a proven leader in the design and implementation ... from discovery to translation, clinical operations and commercial preparedness. ...
(Date:5/21/2013)... 21, 2013  On May 9, 2013, FTI ... global business advisory firm dedicated to helping organizations ... announced that it has combined the healthcare and ... within the Corporate Finance/Restructuring segment with those in ... a single integrated practice whose financial results and ...
Breaking Biology Technology:Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2
... French agency Agence de Medecine,Preventive (AMP) announced today ... for the SIVAC (Supporting Independent Immunization and,Vaccine Advisory ... development of national immunization technical advisory groups in ... Asia. These committees will help,national health authorities to ...
... PARK, Ill. and SANTA ANA, Calif., Jan. 12 ,Abbott ... EYE ) announced,today a definitive agreement for Abbott ... total transaction value of approximately $2.8 billion, inclusive,of estimated net ... Ana, Calif., AMO,is a global leader in ophthalmic care, comprised ...
... /PRNewswire-Asia-FirstCall/ -- China,Pharma Holdings, Inc. ("China Pharma") ... markets specialty pharmaceutical products in China,today announced ... ("SFDA"),approved the production of Tiopronin Enteric-Coated Capsules. ... Insurance Program, thus allowing patients to,obtain reimbursement. ...
Cached Biology Technology:French Agency AMP Appoints Dr Kamel Senouci as Director of SIVAC Initiative (Supporting Independent Immunization and Vaccine Advisory Committees) 2French Agency AMP Appoints Dr Kamel Senouci as Director of SIVAC Initiative (Supporting Independent Immunization and Vaccine Advisory Committees) 3Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 2Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 3Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 4Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 5Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 6Abbott Expands Its Growing Medical Device Business With Acquisition of Advanced Medical Optics (AMO) 7China Pharma Holdings, Inc. Receives SFDA Production Approval for Tiopronin Enteric-Coated Capsules 2China Pharma Holdings, Inc. Receives SFDA Production Approval for Tiopronin Enteric-Coated Capsules 3
... derived from the Spodoptera frugiperda Sf21 cell line ... transfections, plaque assays, virus production, and protein expression. ... optimizes recovery of viable cells after thawing. They ... Cell Medium and can also be grown in ...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
... thermal cycler is a dual-bay expansion for ... operated independently, using a PC. The Dyad ... units (sample-holder, heat-pump assemblies), which hold different ... real-time detector. Peltier heat pumps provide exceptional ...
...
Biology Products: