Navigation Links
Key brain regulatory gene shows evolution in humans

e -- showed evidence of "negative selection" that would preserve their original structure.

A key experiment, said Wray, was a laboratory demonstration that such regulatory mutations did have functional significance. When the researchers cultured human neural cells with either the human or chimpanzee regulatory PDYN segments, they found that the human segments caused the cells to produce more PDYN neuropeptide.

"So, these experiments told us that those mutations that we flagged by a statistical method as being likely to be under selection actually do something important in terms of function," said Wray. "The human version increases expression of the gene and production of prodynorphin, which is the direction of change we predicted."

The researchers also found evidence of evolutionary selection when they compared the regulatory sequences in people from different populations -- including those from Cameroon, China, Ethiopia, India, Italy and Papua New Guinea. Those analyses showed higher differences among the individual populations, but reduced variation within them. Such a pattern is a signature of evolutionary selection acting on the genetic sequence, said Wray.

Still mysterious, he said, is how the prodynorphin gene changes affect human neural development.

"All we can conclude now is that this gene is a very strong candidate for having a functional role in human evolution, and that its role probably has something to do with cognition. But beyond that, it's very hard to make a clear argument about specifically what that role is.

"We do know that not making enough prodynorphin causes clinical problems, but we don't know what having more of it did for us humans. We're hoping the clinical psychiatrists and psychologists can give us more insight into that aspect."

Wray and his colleagues have already identified a collection of some 250 other candidate genes -- mainly those active in the brain -- that they are beginn
'"/>

Source:Duke University


Page: 1 2 3 4

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key brain regulatory gene shows evolution humans

(Date:4/2/2015)... Md. , April 2, 2015 At ... Salt Lake City , the American College ... of five new directors to its Board.  Members of ... the ACMG and for forming and advancing its policies ... medical genetics profession. "It,s an eventful time ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... not affect how long you will live. Instead it is how ... reveals research from the University of Gothenburg recently published in the ... that people with parents who lived to be very old are ... that,s just not true our study shows that hereditary factors ...
... be a problem of towns and cities but new research published ... shows that binge drinking in rural areas is more of ... Psychiatric University Clinic Erlangen, looked at the drinking patterns of over ... more than 93% of the young people from the countryside and ...
... Kyoto, Japan -- In a complex feat of ... the University of Oxford have succeeded in creating a ... be observed in real time. The results, appearing in ... the door to the development of advanced drug delivery ...
Cached Biology News:Lifestyle affects life expectancy more than genetics 2
(Date:4/20/2015)... , April 20, 2015 PointCross Life ... Ltd. to provide an integrated Big Data and globally ... biomarkers collected in the context of clinical trials and ... precise or multi-targeted drug candidates, stratified patient selection and ... progression free survival. Highlighting the timing ...
(Date:4/20/2015)... ANGELES , April 20, 2015  "Everybody is ... we do to patients is frankly brutal. We,ve got ... in a cancer ward, or witnessed a loved one ... you,ve witnessed firsthand the devastation chemotherapy and other treatments ... most people want to give up and succumb to ...
(Date:4/20/2015)... 2015 /CNW/ - Portage Biotech Inc. ("Portage" or "the ... pleased to announce that its wholly owned subsidiary, Portage ... that showed one of its proprietary human-derived CPP sequences ... through inhibition of NFkB signalling even if administered when ... of the blood brain barrier (BBB) in mice was ...
(Date:4/20/2015)... 20, 2015   Meditope Biosciences, Inc ., a ... technology, today announced presentation of data demonstrating the use ... antibody-drug conjugates (ADCs). The data were presented in an abstract ... 18-22 in Philadelphia . ... point to the many commercial applications that may be ...
Breaking Biology Technology:PointCross Life Sciences and InterpretOmics partner for Clinical and Genomic Biomarker Management for Drug Development 2Is Dr. Craig Dionne the Steve Jobs of Cancer Research? 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 3Meditope Biosciences Presents Data At The American Association Of Cancer Research (AACR) Annual Meeting Validating Its SnAP Technology Platform 2
... IL - SecurePipe , a provider of ... an agreement to acquire the assets of Mycom's ... management technologies from Cincinnati-based Mycom Group, Inc. , ,SecurePipe ... sectors such as manufacturing, education, health care and financial ...
... Madison, Wis. - R&D Magazine has ... a 2005 R&D 100 Award, which recognizes the most ... past year. , ,The VANTEC-2000 system is an advanced ... science, materials science and nanotechnology research fields. It enables ...
... been utilized by thousands of U.S. companies since the ... fact, lawmakers in more than 35 states have introduced ... as an effective cost-cutting tool has begun to soar. ... offshore outsourcing, it was often viewed as ...
Cached Biology Technology:Consider the legal issues before outsourcing offshore 2Consider the legal issues before outsourcing offshore 3Consider the legal issues before outsourcing offshore 4Consider the legal issues before outsourcing offshore 5
... amber to slightly cloudy liquid. Yellow, ... per set, each containing 10 ml ... the following proportions by weight: 85% ... monooleate emulsifier), and 0.1% Mycobacterium ...
... been many modifications to the original formulas in ... still play an important role in tissue,culture. A ... and osmotic balance in the medium and to ... ions, is as valuable today as when it ...
Request Info...
... ion trap mass spectrometer enables high-throughput solutions ... LXQ linear ion trap mass spectrometer is ... delivering the fast cycle time and increased ... at an attractive price. The combination ...
Biology Products: