Navigation Links
Key brain regulatory gene shows evolution in humans

Researchers have discovered the first brain regulatory gene that shows clear evidence of evolution from lower primates to humans. They said the evolution of humans might well have depended in part on hyperactivation of the gene, called prodynorphin (PDYN), that plays critical roles in regulating perception, behavior and memory.

They reported that, compared to lower primates, humans possess a distinctive variant in a regulatory segment of the prodynorphin gene, which is a precursor molecule for a range of regulatory proteins called "neuropeptides." This variant increases the amount of prodynorphin produced in the brain.

While the researchers do not understand the physiological implications of the activated PDYN gene in humans, they said their finding offers an important and intriguing piece of a puzzle of the mechanism by which humans evolved from lower primates.

They also said that the discovery of this first evolutionarily selected gene is likely only the beginning of a new pathway of exploring how the pressure of natural selection influenced evolution of other genes.

They also said their finding demonstrates how evolution can act more efficiently to alter the regulatory segments, or "promoters," that determine genes' activity, rather than on the gene segment that determines the structure of the protein it produces. Such regulatory alteration, they said, can more readily generate variability than the hit-or-miss mutations that alter protein structure and function.

Proteins constitute the molecular machinery of the cell, for example, catalyzing the multitude of chemical reactions in the cell. DNA genes constitute the blueprints for such proteins, with the regulatory segments of these genes determining how actively the genes churn out proteins.

The researchers published their findings in the December 2005 issue of the Public Library of Science. They were Gregory Wray and David Goldstein of Duke University; Matthew Rockma
'"/>

Source:Duke University


Page: 1 2 3 4

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key brain regulatory gene shows evolution humans

(Date:8/27/2014)... of the human genome was unveiled today in the ... comparison yet of how the genomes of the fruit ... appearing August 28 in in the journal Nature ... species, genomes is "read out," and how their DNA ... add billions of entries to a publicly available archive ...
(Date:8/27/2014)... be getting effective doses of the HIV drug maraviroc, ... dosing studies, completed before the drug was licensed in ... that is key to removing maraviroc from the body. ... of the protein including nearly half of African-Americans ... compared to those who lack the protein even when ...
(Date:8/27/2014)... SALT LAKE CITY, Aug. 27, 2014 University of ... in his native Turkey, has won that nation,s highest ... Medal of Science. , Sekercioglu is among five researchers ... Scientific and Technical Research Council of Turkey. Three researchers ... won the Special Award, which is equivalent to ...
Breaking Biology News(10 mins):Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Dosage of HIV drug may be ineffective for half of African-Americans 2University of Utah biologist wins Turkey's top science prize 2
... levels of greenhouse gases, particularly carbon dioxide (CO2), ... fuels, deforestation, cultivation of grasslands, drainage of the ... shifts in climate patterns have led scientists to ... and to develop methods to evaluate how changes ...
... On Monday 4 February, Dennis J. Selkoe and five other ... Leuven. The promoters for this honorary doctorate VIB-KU Leuven ... Dennis J. Selkoe for his scientific insights, but also for ... and other conditions that cause severe damage in the brain. ...
... RayBiotech, Inc. announced today that it has executed ... Institute (BSHRI) of Sun City, Arizona.  Under the terms ... the biochemical analysis of disease markers in biological samples.  ... the characterization of key biomarkers for the study of ...
Cached Biology News:New protocol recommendations for measuring soil organic carbon sequestration 2New protocol recommendations for measuring soil organic carbon sequestration 3New protocol recommendations for measuring soil organic carbon sequestration 4Prevention is better than cure. Also for Alzheimer's disease! 2Prevention is better than cure. Also for Alzheimer's disease! 3Prevention is better than cure. Also for Alzheimer's disease! 4RayBiotech, Inc. Executes Neuroscience Biomarker Master Services Agreement with Banner Sun Health Research Institute 2RayBiotech, Inc. Executes Neuroscience Biomarker Master Services Agreement with Banner Sun Health Research Institute 3
(Date:8/27/2014)... 27, 2014 Research and Markets  has ... Ratio Mass Spectrometer Industry Report 2014" report to ... Ratio Mass Spectrometer Industry Report 2014 is a professional ... global isotope ratio mass spectrometer industry. The ... definitions, classifications, applications and industry chain structure. The isotope ...
(Date:8/27/2014)... 27, 2014 Riviera Beach, Florida ... the creation of the Sancilio Scientific Advisory Board ... SCI’s philosophy of looking to nature for pharmaceutical ... actions are based on sound scientific data, analyses, ... Board provides a vehicle for SCI to receive ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 According to ... continues to reshape the look and feel of markets ... demand for higher-quality ingredients will push for more branded, ... market have experienced strong market growth in the last ... in their food and cosmetics to fit a more ...
(Date:8/27/2014)... August 27, 2014 Budding Biomedical ... University School participated in the Scientific ... Reserve University’s School of Medicine . ... an unparalleled professional experience in the sciences and ... Medicine faculty and students for both academic and ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... . Most people value large chunks of gold ... gold at the smallest possible scale, because single gold atoms are ... atoms are placed on a surface they tend to ball up ... scientists now managed to fix single gold atoms on special sites ...
... May 30, 2012  Luminex Corporation (NASDAQ: LMNX ... Jefferies 2012 Global Healthcare Conference to be held June ... ) The investor presentation by Patrick J. ... 1:30 p.m. Eastern time on Wednesday, June 6, 2012.  The ...
... Inc. (Nasdaq: AUXL ) today announced that executive ... to be held June 4-7, 2012 at the Grand Hyatt ... and President, is scheduled to present an overview of the ... Monday, June 4, 2012. A breakout session will be held ...
Cached Biology Technology:The finest gold dust in the world 2Luminex Corporation to Present at Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 3Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 4
... Situ Assay Kit is a fluorescent-based assay ... undergoing apoptosis. The kit is for research ... or therapeutic procedures. CHEMICON®s CaspaTag™ Pan-Caspase In ... to detect active caspases. The methodology is ...
... INTERFERin is a new-generation siRNA transfection ... efficiency at 1 nM siRNA in a ... with excellent cell viability. Using low siRNA ... effects observed when transfecting siRNA at higher ...
... R&D Systems Cell and Tissue Staining Kits ... a broad range of histological and cytological ... primary IgG antibodies manufactured by either R&D ... is based on the formation of the ...
... measurements in an easy-to-use benchtop package. ... spectrometer (ESI-oa-TOF) concentrates the performance of ... which fits on your bench. The ... 10,000 FWHM and mass accuracy of ...
Biology Products: