Navigation Links
Keeping the body in sync -- The stability of cellular clocks

A study in Switzerland uses the tools of physics to show how our circadian clocks manage to keep accurate time in the noisy cellular environment.

In an article appearing March 13 in the journal Molecular Systems Biology, researchers from the Ecole Polytechnique Federale de Lausanne demonstrate that the stability of cellular oscillators depends on specific biochemical processes, reflecting recent association studies in families affected by advanced sleep phase syndrome.

Circadian rhythms are cyclical changes in physiology, gene expression, and behavior that run on a cycle of approximately one day, even in conditions of constant light or darkness. Peripheral organs in the body have their own cellular clocks that are reset on a daily basis by a central master clock in the brain. The operation of the cellular clocks is controlled by the coordinated action of a limited number of core clock genes. The oscillators work like this: the cell receives a signal from the master pacemaker in the hypothalamus, and then these clock genes respond by setting up concentration gradients that change in a periodic manner. The cell “interprets?these gradients and unleashes tissue-specific circadian responses. Some examples of output from these clocks are the daily rhythmic changes in body temperature, blood pressure, heart rate, concentrations of melatonin and glucocorticoids, urine production, acid secretion in the gastrointestinal tract, and changes in liver metabolism.

In the tiny volume of the cell, however, the chemical environment is constantly fluctuating. How is it possible for all these cell-autonomous clocks to sustain accurate 24-hour rhythms in such a noisy environment?

Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University of Geneva, the researchers turned to dynamical systems theory and developed a mathematical model that identified the molecular parameters responsible for the stability of th
'"/>

Source:Ecole Polytechnique F茅d茅rale de Lausanne


Page: 1 2

Related biology news :

1. Keeping the immune system from starting a food fight
2. Enzyme shown to help protect genomic stability
3. A bugs life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist
4. Signature of chromosome instability predicts cancer outcomes
5. Scientists discover the cellular roots of graying hair
6. Vital step in cellular migration described by UCSD medical researchers
7. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
8. New study to explore cellular circuitry
9. Study provides insight into cellular defenses against genetic mutation
10. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
11. Liver cancer linked to cellular repair pathway
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Keeping the body sync The stability cellular clocks

(Date:9/15/2014)... One of Australia,s leading coral reef ecologists fears that ... for ecosystem survival that we once thought. , In ... the ARC Centre of Excellence for Coral Reef Studies ... the most important species within reef ecosystems. , In ... are vital jobs that keep the ecosystem safe and ...
(Date:9/15/2014)... professor in the Department of Science and Technology in ... Sciences at Virginia Tech, has won a 2014 National ... the prospects and problems of creating a global nuclear ... Fukushima I Nuclear Power Plant in March 2011 was ... nuclear emergencies, Schmid said. Three of the plant,s six ...
(Date:9/15/2014)... of the cheetah: The big predator is the fastest land ... just a few seconds. As it ramps up to top ... it reaches a full gallop. , Now MIT researchers have ... a robotic cheetah a sleek, four-legged assemblage of gears, ... its feline counterpart. The team recently took the robot for ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2Run, cheetah, run 2Run, cheetah, run 3
... of climate change on the microbial communities of two ... in Alaska, a University of Oklahoma research group has ... According to Jizhong Zhou, OU professor of botany ... Genomics, the results of these studies could potentially contribute ...
... WORCESTER, Mass. Researchers at the University of Massachusetts Medical ... which is implicated in 20 percent of inherited cases of ... a part in sporadic forms of the disease. Discovery of ... edition of Nature Neuroscience . While the SOD1 ...
... 18 October 2010, Singapore A total of 15 world ... in their respective fields at the 6th Decade of the ... 20 October 2010. Jointly organised by A*STAR,s Institute of ... (DRTech) and NUS,s Temasek Laboratories, it is the first such ...
Cached Biology News:UMMS researchers identify protein associated with sporadic ALS 2UMMS researchers identify protein associated with sporadic ALS 3Singapore hosts first 'Decade of the Mind' conference in Asia 2Singapore hosts first 'Decade of the Mind' conference in Asia 3
(Date:9/15/2014)... Hydro Dynamics, Inc. (HDI) of Rome, ... will be partnering with Proteaf Technologies (Proteaf) of ... implementing its Shock Wave Power Reactor (SPR) cavitation ... flow chemistry through process intensification has been widely ... for decades. The continuous chemistry has been ...
(Date:9/14/2014)... wide variety of ways, including by modifying the protein ... another form and perform no or even the "wrong" ... serious diseases such as Alzheimer,s, Parkinson,s or cystic fibrosis. ... "infect" other molecules of the same type and congregate ... can damage cells and tissues and make people ill. ...
(Date:9/13/2014)... Boehringer Laboratories Inc., with a forty year history ... successful broadcast of a live surgery by St. Luke’s ... FAMBS, and Maher El Chaar, MD, FACS, FAMBS, using ... This sleeve gastrectomy surgery was performed and broadcast live ... surgeons from around the world during the 5th International ...
(Date:9/12/2014)... 2014   Arthur Kay , the 23-year-old British ... Postcode Lottery Green Challenge 2014. The jury, chaired by ... USD) at the final in Amsterdam ... Kay,s company uses a patented process to upcycle ... and biomass pellets, used for powering buildings and transport ...
Breaking Biology Technology:Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Measuring modified protein structures 2Measuring modified protein structures 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3
... is,strengthening its customer-focused biomarker services portfolio to,pharmaceutical, ... Xie will lead those efforts as Battelle,s ... a suite of biomarker services, including biomarker,discovery, ... clients,better define molecular mechanisms of diseases, toxicity, ...
... against management - with six million, votes revoked ... change rules, TORONTO, June 25 /PRNewswire/ - The ... be in court today and will seek a,declaration that ... Meeting,was illegally held and will request that a proper ...
... probiotic ingredient, GanedenBC30, to power new raisin bran probiotic muffins. ... ... Main Street Gourmet, one of the fastest growing manufacturers of gourmet ... muffin fortified with the high-survivability probiotic, GanedenBC30 (Bacillus coagulans ...
Cached Biology Technology:Battelle Selects Xie to Develop Biomarker Services 2Main Street Gourmet Launches New Probiotic Muffins 2Main Street Gourmet Launches New Probiotic Muffins 3
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... The new TC-412 thermal cycler, flexible on your ... is a high performance, high sample throughput instrument ... , Flexible block format: The truly user-friendly ... exchanged in a matter of seconds without the ...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
Biology Products: