Navigation Links
Keeping the body in sync -- The stability of cellular clocks

A study in Switzerland uses the tools of physics to show how our circadian clocks manage to keep accurate time in the noisy cellular environment.

In an article appearing March 13 in the journal Molecular Systems Biology, researchers from the Ecole Polytechnique Federale de Lausanne demonstrate that the stability of cellular oscillators depends on specific biochemical processes, reflecting recent association studies in families affected by advanced sleep phase syndrome.

Circadian rhythms are cyclical changes in physiology, gene expression, and behavior that run on a cycle of approximately one day, even in conditions of constant light or darkness. Peripheral organs in the body have their own cellular clocks that are reset on a daily basis by a central master clock in the brain. The operation of the cellular clocks is controlled by the coordinated action of a limited number of core clock genes. The oscillators work like this: the cell receives a signal from the master pacemaker in the hypothalamus, and then these clock genes respond by setting up concentration gradients that change in a periodic manner. The cell “interprets?these gradients and unleashes tissue-specific circadian responses. Some examples of output from these clocks are the daily rhythmic changes in body temperature, blood pressure, heart rate, concentrations of melatonin and glucocorticoids, urine production, acid secretion in the gastrointestinal tract, and changes in liver metabolism.

In the tiny volume of the cell, however, the chemical environment is constantly fluctuating. How is it possible for all these cell-autonomous clocks to sustain accurate 24-hour rhythms in such a noisy environment?

Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University of Geneva, the researchers turned to dynamical systems theory and developed a mathematical model that identified the molecular parameters responsible for the stability of th
'"/>

Source:Ecole Polytechnique F茅d茅rale de Lausanne


Page: 1 2

Related biology news :

1. Keeping the immune system from starting a food fight
2. Enzyme shown to help protect genomic stability
3. A bugs life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist
4. Signature of chromosome instability predicts cancer outcomes
5. Scientists discover the cellular roots of graying hair
6. Vital step in cellular migration described by UCSD medical researchers
7. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
8. New study to explore cellular circuitry
9. Study provides insight into cellular defenses against genetic mutation
10. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
11. Liver cancer linked to cellular repair pathway
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Keeping the body sync The stability cellular clocks

(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/4/2014)... 3, 2014  Crossmatch™, a leading provider of ... DigitalPersona ® Pro Enterprise software and U.are.U ... throughout First Bank branch locations in ... and Virginia. First Bank, a progressive community ... North Carolina , selected the Crossmatch biometrics-based ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... Behaviour Using Accelerometry in Cane Toads Bufo marinus ... were introduced to Australia as a control agent but now ... they enter. Predictive models that can give expansion rates as ... to maximise control efficiency but to date no study has ...
... Does your drinking water smell foul, or are you ... Water treatment facilities currently use chlorine that produces carcinogenic ... University scientists have determined that ultra-violet (UV) light might ... of Tel Aviv University,s Porter School of Environmental Science ...
... supplements has found no evidence that they offer benefits for ... investigated the effects of taking omega-3 long-chain polyunsaturated fatty acid ... of participants aged 70-80 years. The number of people ... by 2040, more than 81 million people globally will have ...
Cached Biology News:Cane toad accelerometry and more 2Cane toad accelerometry and more 3Cane toad accelerometry and more 4Cane toad accelerometry and more 5Cane toad accelerometry and more 6Water, fair and foul 2Fish oil supplements provide no benefit to brain power 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... HEIGHTS, N.J., May 6 Genta,Incorporated (Nasdaq: ... received,notification from the NASDAQ Listing Qualifications Panel that ... sustain compliance with the,minimum stockholders, equity requirement for ... has also determined that de-listing from,The NASDAQ Capital ...
... May 6 Caliper Life,Sciences, Inc. (Nasdaq: ... the,Deutsche Bank,s 33rd Annual Health Care Conference in ... at 8:50 a.m. EDT. Kevin,Hrusovsky, President and CEO ... the,company,s business. The live webcast can be accessed ...
... Leading OAB Drug in China, PLYMOUTH MEETING, ... BJGP ) ("BMP Sunstone" or the "Company") ... Enablex(R),(Darifenacin) was officially accepted by China,s State Food ... SFDA requirement prior to,pursuing a clinical trial and, ...
Cached Biology Technology:Genta Announces Pending Transfer of its Common Stock to the Over-the-Counter Bulletin Board 2Genta Announces Pending Transfer of its Common Stock to the Over-the-Counter Bulletin Board 3BMP Sunstone Receives SFDA Acceptance for Enablex(R) Clinical Trial 2BMP Sunstone Receives SFDA Acceptance for Enablex(R) Clinical Trial 3
... PCR carry-over contamination, which prevents false ... products from previous PCR amplifications without ... improves amplification ,Optimized for use with ... instrument systems , The GeneAmp PCR ...
... that catalyzes the hydrolysis of,starch to ... dextrins. The,level of a-amylase in various ... of,clinical significance in the diagnosis of ... and microbial a-amylases are,important enzymes for ...
... Labsystems Wellmix is a high-quality four-place microplate ... The shaking speed is adjustable from 100 ... speed and a small orbit ensure effective ... time is quick and easy to set ...
Rabbit polyclonal to STUB1 ( Abpromise for all tested applications). entrezGeneID: 10273 SwissProtID: Q9UNE7...
Biology Products: