Navigation Links
Keeping the body in sync -- The stability of cellular clocks

A study in Switzerland uses the tools of physics to show how our circadian clocks manage to keep accurate time in the noisy cellular environment.

In an article appearing March 13 in the journal Molecular Systems Biology, researchers from the Ecole Polytechnique Federale de Lausanne demonstrate that the stability of cellular oscillators depends on specific biochemical processes, reflecting recent association studies in families affected by advanced sleep phase syndrome.

Circadian rhythms are cyclical changes in physiology, gene expression, and behavior that run on a cycle of approximately one day, even in conditions of constant light or darkness. Peripheral organs in the body have their own cellular clocks that are reset on a daily basis by a central master clock in the brain. The operation of the cellular clocks is controlled by the coordinated action of a limited number of core clock genes. The oscillators work like this: the cell receives a signal from the master pacemaker in the hypothalamus, and then these clock genes respond by setting up concentration gradients that change in a periodic manner. The cell “interprets?these gradients and unleashes tissue-specific circadian responses. Some examples of output from these clocks are the daily rhythmic changes in body temperature, blood pressure, heart rate, concentrations of melatonin and glucocorticoids, urine production, acid secretion in the gastrointestinal tract, and changes in liver metabolism.

In the tiny volume of the cell, however, the chemical environment is constantly fluctuating. How is it possible for all these cell-autonomous clocks to sustain accurate 24-hour rhythms in such a noisy environment?

Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University of Geneva, the researchers turned to dynamical systems theory and developed a mathematical model that identified the molecular parameters responsible for the stability of th e cellular clocks. Stability is a measure of how fast the system reverts to its initial state after being perturbed.

“To my knowledge we are the first to discuss how the stability of the oscillator directly affects bioluminescence recordings,?explains Felix Naef, a systems biology professor at EPFL and the Swiss Institute for Experimental Cancer Research. “We found that the phosphorylation and transcription rates of a specific gene are key determinants of the stability of our internal body clocks.?

This result is consistent with recent research from the University of California, San Francisco involving families whose circadian clocks don’t tick quite right. These families?clocks are shorter than 24 hours, and they also have mutations in oscillator-related genes. The current results shed light on how a genetically-linked phosphorylation event gone wrong could lead to inaccurate timing of our body clockworks.
'"/>

Source:Ecole Polytechnique F茅d茅rale de Lausanne


Related biology news :

1. Keeping the immune system from starting a food fight
2. Enzyme shown to help protect genomic stability
3. A bugs life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist
4. Signature of chromosome instability predicts cancer outcomes
5. Scientists discover the cellular roots of graying hair
6. Vital step in cellular migration described by UCSD medical researchers
7. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
8. New study to explore cellular circuitry
9. Study provides insight into cellular defenses against genetic mutation
10. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
11. Liver cancer linked to cellular repair pathway

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... 31, 2016 BioRap Technologies Ltd ... Biomedical Research at the Technion - Israel Institute of Technology, ... with Pfizer Inc. (NYSE: PFE ) that aims ... treatment options for a number of chronic autoimmune diseases. ... by Prof. Nathan Karin and his research team, ...
(Date:5/31/2016)... MB (PRWEB) , ... May 31, 2016 , ... ... develops and markets molecular imaging systems, today announced that their compact PET scanner ... (Magnetic Resonance Imaging) has been selected by the University of Arizona (UA). , ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Weeks after hosting ... in Phoenix, Dr. Michael Fitzmaurice, hand surgeon and founder of the Fitzmaurice Hand Institute, ... The Wrist MRI machine is a state-of-the-art technology and only 1 of about 3 ...
(Date:5/27/2016)... Jersey and READING, ... -- Indegene ( http://www.indegene.com ), ... marketingorientierten Lösungen für die Life-Science-Branche, Pharmaunternehmen und ... bekannter weltweiter Anbieter von innovativen wissenschaftlichen Support-Services ... des Starts von IntraScience heute den Ausbau ...
Breaking Biology Technology: