Navigation Links
K-State professors discover enzyme responsible for creation of a beetle's hard shell

Kansas State University researchers think their discovery of the enzyme involved in the hardening of a beetle's exoskeleton or cuticle could lead not only to better pest control, but also help create similar strong, lightweight materials for use in aircraft and armor.

After a beetle first molts, its exoskeleton is soft and hydrated. Somehow, it dries out and forms a hard, stiff exoskeleton. Since the 1940s, scientists have wondered which enzyme among several possible candidates was involved in the hardening process.

The K-State researchers have found that by knocking out an enzyme called laccase-2, cuticle tanning, the process of hardening and pigmentation, can be prevented in the red flour beetle, Tribolium castaneum.

A paper, to be released this week in the Proceedings of the National Academy of Sciences, presents the research results. The K-State researchers are Yasuyuki Arakane, research associate in biochemistry; Subbaratnam Muthukrishnan, professor of biochemistry; Richard Beeman, adjunct professor of entomology; Michael Kanost, professor and head of the department of biochemistry; and Karl Kramer, adjunct professor emeritus of biochemistry.

Kramer said K-State researchers wanted to find out what happens between the times when the cuticle is soft and when it is hard. They studied the cuticle's composition and how the components interacted to give it stiffness, flexibility and lightness. The main components in the cuticle are proteins and chitin, which also are found in crustaceans and other invertebrates.

The researchers knew one of two classes of oxidative enzymes, tyrosinases or laccases, is likely responsible for catalyzing the exoskeleton's hardening by cross-linking cuticular proteins, Kanost said.

"When we knocked out tyrosinase, everything was normal," Kramer said. "When we knocked out laccase-2, we prevented tanning from taking place."

When the laccase-2 gene was not expressed, the newly formed cut
'"/>

Source:Kansas State University


Page: 1 2

Related biology news :

1. K-State researchers study insects immune system
2. K-State researchers study gene regulation in insects
3. K-Staters design and build a low-cost remote sensing tool for environmental studies
4. UAB scientists discover the origin of a mysterious physical force
5. Researchers discover way to make cells in the eye sensitive to light
6. Protein discovery could unlock the secret to better TB treatment
7. Newly-discovered class of genes determines ?and restricts ?stem cell fate
8. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
9. Purdue proves concept of using nano-materials for drug discovery
10. Scientists discover the cellular roots of graying hair
11. Researchers discover molecule that causes secondary stroke
Post Your Comments:
(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... Virginia Institute of Marine Science have received a ... to identify the streams and wetlands most vulnerable ... help local governments and citizens conserve these important ... dataset of tidal-marsh observations first gathered by VIMS ... baseline can today,s researchers accurately map the slow ...
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... today center for discovery, economic growth engine, innovation hub, ... prepared for the challenges that lie ahead? , Is America ... , People are our greatest asset how do we ... the fiscal crisis on America,s research enterprise? , , ...
... 2012. Researchers from the University of Maryland School of ... bone marrow in mice to help create tissue cells of ... a scientific step they hope may lead to potential new ... Parkinson,s or Alzheimer,s. The research in collaboration with the University ...
... July 3, 2012 Exposure to childhood maltreatment increases ... many negative consequences of these conditions. This new ... University, Canada, provides important insight into one of the ... expanded our previous work on the epigenetic regulation of ...
Cached Biology News:All Things Research 2012 roundtable discussion 2Study results: Adult stem cells from bone marrow 2Highlighting molecular clues to the link between childhood maltreatment and later suicide 2
(Date:10/22/2014)... SC (PRWEB) October 22, 2014 ... of its cardiovascular pharmacogenetics menu, which enables healthcare ... outcomes. With PCLS’s evidence-based results, healthcare providers ... and optimize their therapy, while minimizing risks for ... the U.S., according to the FDA [1] more ...
(Date:10/22/2014)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... its Oral Amphotericin B program.  The company recently ... work involving samples from HIV/AIDS patients exposed ... pre clinical studies and regulatory filings to move ... utilizing approximately $700,000 of funding and technological advice ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
(Date:10/20/2014)... October 20, 2014 Convey Computer ... a team from Iowa State University won first place ... Using a Convey HC-2ex, the team’s solution achieved the ... faster than the second place finisher. , Experts from ... upon the month long challenge, using a variety of ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... Indoor spraying with the insecticide bendiocarb has dramatically decreased ... that insecticides remain a potent weapon for fighting malaria ... an entire class of mosquito-killing compounds, according to a ... The American Journal of Tropical Medicine and Hygiene ...
... Texas, Oct. 5, 2011 Luminex Corporation (NASDAQ: ... the National Marrow Donor Program – Be The Match to ... the chances of finding a match for the growing number ... 100 Luminex employees joined the National Marrow Donor Registry in ...
... ANN ARBOR, Mich., Oct. 5, 2011 Adeona Pharmaceuticals, Inc. ... medicines for serious central nervous system diseases, announced today that ... and Chairman, will provide a brief update on its Alzheimer,s ... of four featured companies at the invitation-only event on Tuesday ...
Cached Biology Technology:Scientists determine alternative insecticide dramatically reduces malaria transmission 2Scientists determine alternative insecticide dramatically reduces malaria transmission 3Scientists determine alternative insecticide dramatically reduces malaria transmission 4Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 3Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 4Adeona CEO to Present at the NYC Medtech Forum 2
... Analysis Note: The kit contains all the ... determination of NADPH-cytochrome c reductase activity in ... microsomes [endoplastic reticulum (ER)]. It has been ... such as liver, kidney, brain, spleen, and ...
... Strain Competent Cell Sets Sets of ... combinations The most common method ... coli is to use chemically competent ... in the laboratory, greater efficiency, reproducibility and ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... DNA Methylation Kit uses a simplified procedure ... methylation analysis. The kit is based on ... between cytosine and sodium bisulfite where cytosine ... Methylation Kits innovative in-column desulphonation reaction eliminates ...
Biology Products: