Navigation Links
Junk DNA may not be so junky after all

ditionally, DNA sequences are thought to have to look similar to function similarly; this is how scientists identify genes in other species, a strategy best used for studying similar species. From an evolutionary standpoint, the last common ancestor of human and zebrafish lived more than 300 million years ago. Because DNA sequences in each species have changed over time, traditional methods of comparing DNA sequences between humans and zebrafish have failed to identify any potential enhancers around the RET gene because the DNA sequences differ too much.

That drove the Hopkins researchers to seek and develop this new system, by which virtually any DNA sequence can be tested for its ability to turn on a marker gene in zebrafish embryos. The system is a significant advance over current methods in this model species, allowing researchers to study more sequences in a shorter period of time. Using this, they identified several human enhancers able to control expression consistent with the zebrafish ret gene.

Zebrafish have become the ideal system for doing these types of large scale studies. They are small - only about a half inch in length - they grow quickly, and are relatively inexpensive to maintain compared to mice or rats. "Zebrafish are the only vertebrate embryo you can even think about doing this type of work in," says Shannon Fisher, M.D., Ph.D., the study's first author and an assistant professor in cell biology in Johns Hopkins' Institute for Basic Biomedical Sciences.

The researchers' next steps are further study of the RET enhancers they found to identify other mutations that might contribute to Hirschsprung disease and MEN2, and to entice other investigators to collectively build a database of human enhancers. "If there's one thing we've learned here, it's that we are not very good at recognizing enhancers. We just don't know what they look like," says Fisher. "We are anxious for others to use this technology on their favorite gen
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Does vitamin C help prevent or treat the common cold? Maybe not, after all.
3. Stem cell treatment improves mobility after spinal cord injury
4. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
5. New type of rejection blocker protects kidneys after transplant
6. Hurricane aftermath: Infectious disease threats from common, not exotic, diseases
7. Bone marrow stem cells may heal hearts even years after heart attacks
8. Many smokers fail to quit after cancer diagnosis
9. Getting an evolutionary handle on life after reproduction
10. Stroke treatment a step closer after trial
11. Hormonal male contraception reversible after few months for all men
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Junk DNA may not junky after all

(Date:5/18/2015)... Fingerprint Cards (FPC) has received an ... and FPC1035 from one if its module partners. Deliveries are ... 2015 and the sensors will be used by smartphone manufacturers ... 2015 hereby amount to 740 MSEK to date. In addition ... and a number of smaller orders not separately communicated amounting ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
(Date:5/10/2015)... , May 11, 2015 Fingerprint Cards ... FPC1025 and FPC1155 from the distributor World Peace Industrial Group ... distributors in Asia . Deliveries are planned ... be used by smartphone manufacturers in China ... the communicated revenue guidance of + 1 000 MSEK for 2015. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... A new analysis has found that the presence of ... papillary thyroid cancer tumors suggests a likelihood of recurrence ... early online in CANCER , a peer-reviewed journal ... blood levels of the genetic material after surgery may ...
... to attribute two types of tumour almost entirely to specific ... are found in nearly 100 per cent of patients suffering ... of the bone. Chondroblastoma and giant cell tumour of ... young adults, respectively. They can be extremely debilitating tumours and ...
... A new study that decoded the DNA sequence of ... similarities between its 39,040 genes and other plant species, including ... evolutionary events that occurred millions of years ago in the ... fruit crop. It has long been called ,the king of ...
Cached Biology News:Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer 2Novel mutations define 2 types of bone tumor 2Surprises discovered in decoded kiwifruit genome 2
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Markets and Companies"  to their offering.  ... disease remains a challenge in management. With ... in the seven major markets of the ...
(Date:5/28/2015)... DUBLIN , May 27, 2015 /PRNewswire/ ... announced the addition of Jain PharmaBiotech,s new ... to their offering. An ... and biotechnology industries is anticipated. Nanotechnology will ... development - from formulations for optimal delivery ...
(Date:5/28/2015)... The Academy of Model Aeronautics Foundation will ... August 15, 2015. National Model Aviation Day was created to ... model flying to the general public. , The AMA has ... in the celebration by hosting events in their own communities. ... Aviation Day events. View our online event map to ...
(Date:5/28/2015)... May 28, 2015 BioNorth Texas ... and representing the life sciences industry in northern ... Directors meeting at The Foundry in Dallas on ... organization brought together a broad spectrum of biotech ... the organization's early successes in partnering with key ...
Breaking Biology Technology:Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3
... Feb. 4 Diplomat Specialty Pharmacy is,pleased to ... As of January 2009, DSP launched both a ... Reed has joined Diplomat as National,Sales Manager for ... Indiana University and,has over 18 years of ...
... GAITHERSBURG, Md. and ATLANTA, Feb 4 Lentigen ... and manufacture of lentiviral gene delivery technologies, and ... VIII-based therapeutics, today announced a collaborative agreement to ... A.Hemophilia A is an inherited blood clotting disorder ...
... (NYSE: APD ) and Alter NRG Corp. ... Development Agreement (JDA) to pursue renewable energy opportunities in ... Air Products the right to license and incorporate Alter ... renewable energy projects. Air Products will initially focus ...
Cached Biology Technology:Diplomat Specialty Pharmacy Expands National Hemophilia & IVIG Program 2Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement 2Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement 3Air Products and Alter NRG Sign JDA on Renewable Energy Projects 2Air Products and Alter NRG Sign JDA on Renewable Energy Projects 3Air Products and Alter NRG Sign JDA on Renewable Energy Projects 4
... Rotor for use in the ... and Centra-MP4/MP4R. Perfect for ... and other difficult to separate ... containment. Complete with rotor and ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
Biology Products: