Navigation Links
Junk DNA may not be so junky after all

ditionally, DNA sequences are thought to have to look similar to function similarly; this is how scientists identify genes in other species, a strategy best used for studying similar species. From an evolutionary standpoint, the last common ancestor of human and zebrafish lived more than 300 million years ago. Because DNA sequences in each species have changed over time, traditional methods of comparing DNA sequences between humans and zebrafish have failed to identify any potential enhancers around the RET gene because the DNA sequences differ too much.

That drove the Hopkins researchers to seek and develop this new system, by which virtually any DNA sequence can be tested for its ability to turn on a marker gene in zebrafish embryos. The system is a significant advance over current methods in this model species, allowing researchers to study more sequences in a shorter period of time. Using this, they identified several human enhancers able to control expression consistent with the zebrafish ret gene.

Zebrafish have become the ideal system for doing these types of large scale studies. They are small - only about a half inch in length - they grow quickly, and are relatively inexpensive to maintain compared to mice or rats. "Zebrafish are the only vertebrate embryo you can even think about doing this type of work in," says Shannon Fisher, M.D., Ph.D., the study's first author and an assistant professor in cell biology in Johns Hopkins' Institute for Basic Biomedical Sciences.

The researchers' next steps are further study of the RET enhancers they found to identify other mutations that might contribute to Hirschsprung disease and MEN2, and to entice other investigators to collectively build a database of human enhancers. "If there's one thing we've learned here, it's that we are not very good at recognizing enhancers. We just don't know what they look like," says Fisher. "We are anxious for others to use this technology on their favorite gen
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Does vitamin C help prevent or treat the common cold? Maybe not, after all.
3. Stem cell treatment improves mobility after spinal cord injury
4. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
5. New type of rejection blocker protects kidneys after transplant
6. Hurricane aftermath: Infectious disease threats from common, not exotic, diseases
7. Bone marrow stem cells may heal hearts even years after heart attacks
8. Many smokers fail to quit after cancer diagnosis
9. Getting an evolutionary handle on life after reproduction
10. Stroke treatment a step closer after trial
11. Hormonal male contraception reversible after few months for all men
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Junk DNA may not junky after all

(Date:8/31/2014)... for sniffing the highly infectious bacteria C. diff ... been developed by a team at the University of ... has demonstrated that it is possible to identify the ... lead to rapid diagnosis of the condition., What is ... to identify different strains of the disease simply from ...
(Date:8/31/2014)... are not busy attacking us, germs go after each ... spell disaster for the infected microbes: Sometimes viruses actually ... say, expand its diet or better attack its own ... an immune system would robotically destroy anything it recognized ... University have now revealed that one variety of the ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current trends ... the global targets for total greenhouse gas (GHG) emissions in ... think carefully about the food we choose and its environmental ... just one of a number of actions that need to ... is enough food for all. , As populations rise ...
Breaking Biology News(10 mins):Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4
... of Defence (MINDEF) and the Nanyang Technological University (NTU) ... strengthen Singapore,s defence science and technology research and development ... by inking a Memorandum of Understanding (MOU) at the ... the setting up of the Temasek Research Fellowship and ...
... Pharmaceutical Scientists (AAPS) is a professional, scientific society ... government and other research institutes worldwide. Founded in ... the exchange of knowledge among scientists to enhance ... scientific programs, on-going education, information resources, opportunities for ...
... tropical butterfly that potentially makes it able to distinguish between ... from the University of Bristol, UK. The team ... detection of predators, in particular birds. The Blue Morpho ... America, are more famous for their amazing wing colouration and ...
Cached Biology News:MINDEF, NTU join hands to boost Singapore's defense R&D capabilities 2
(Date:8/30/2014)... The Global and China Electrical ... study on the current state of the Electrical ... The report provides a basic overview of the ... Global market analysis and Chinese domestic market analysis ... trends and competitive landscape of the market. A ...
(Date:8/29/2014)... According to a new market report published ... market was valued at USD 3,754.6 million in 2012 and ... 2019at a CAGR of 5.9% from 2013 to 2019. , ... is afflicted by bone and joint disorders, and this number ... has and will continue to increase the demand for orthobiologics. ...
(Date:8/29/2014)... Three Lawrence Livermore researchers have ... Production R&D Award for their research in ... sunlight. , Shared with collaborators from the National ... Nevada, Las Vegas (UNLV), the award recognizes the ... solar-hydrogen production and corrosion processes. , These models ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... A new, one-year, double-blind controlled clinical study shows that ... risk in postmenopausal women with type 2 diabetes [1] ... Peter J. Curtis, Ph.D., et al , funded by ... Ltd., Israel, and Barry Callebaut, the world,s leading manufacturer of ...
... polymers will offer unprecedented control over the final polymer structure ... study published last week in the prestigious journal Nature ... in Sydney and the University of Warwick in the UK ... a combination of segregation and templating a pair of ...
... integrated circuits are found in many applications, from large ... integration is due in part to the semiconductor industry,s ... for decades. However, while silicon-based circuits continue to ... Law the prediction that the number of transistors ...
Cached Biology Technology:New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients 2New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients 3Bio-inspired polymer synthesis enhances structure control 2Next-generation nanoelectronics: A decade of progress, coming advances 2Next-generation nanoelectronics: A decade of progress, coming advances 3
Request Info...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
Rabbit polyclonal to Somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
... an essential component of the COP9 signalosome ... cellular and developmental processes. The CSN complex ... (Ubl) conjugation pathway by mediating the deneddylation ... ligase complexes. The complex is also involved ...
Biology Products: