Navigation Links
Jump-starting T Cells In Skin Cancer

Advanced melanoma, the most deadly form of skin cancer, can be successfully treated in some cases by vaccinating patients with tumor proteins. How these vaccines work and why they are only effective in some patients remains unclear. Pierre Coulie and colleagues now show, in two articles in the January 17 issue of the Journal of Experimental Medicine, that these vaccines work by increasing the number of immune cells called killer T cells that can attack the tumor. In an unexpected finding, however, they discovered that that these cells mostly recognize tumor proteins that were not contained in the vaccine. Understanding the characteristics of the T cell populations that are expanded after vaccination may help in the development of more effective anti-tumor vaccines.

Tumor-specific T cells can be detected in the blood and the tumors of many melanoma patients, and yet these cells are unable to kill the tumor. What causes the impotence of these T cells is a mystery. Equally mysterious is why vaccination against tumor-specific proteins sometimes causes tumor regression without expanding large numbers of vaccine-specific killer T cells.

Pierre Coulie's group studied anti-tumor T cells in patients vaccinated with a tumor antigen called MAGE-3. In one patient whose tumor regressed after vaccination, the authors found significantly more T cells specific for non-vaccine tumor proteins than were detected before vaccination. Vaccine-specific T cells, on the other hand, became detectable but did not expand to large numbers. Thus, reinvigoration of existing tumor-specific T cells after vaccination did not require large numbers of vaccine-specific T cells.

Although it is not known how these tumor-specific cells get activated, Coulie thinks that the few T cells stimulated by the vaccine may change the local, suppressive environment of the tumor such that other T cells can snap out of their stupor and attack the tumor.


'"/>

Source:Journal of Experimental Medecine


Page: 1

Related biology news :

1. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
2. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
3. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
4. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
5. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
6. Placenta Is A Rich Source Of Blood Stem Cells
7. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
8. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
9. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
10. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
11. Human Cells Filmed Instantly Messaging for First Time
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jump starting Cells Skin Cancer

(Date:7/29/2014)... Territories in Canada and have sent smoke drifting down ... NASA,s Aqua satellite collected this natural-color image with ... 26, 2014. Actively burning areas, detected by MODIS,s thermal ... are drifting northward in this image. Smoke is ... has caused power outages in the area and because ...
(Date:7/29/2014)... from scientists at the University of Kent has shown ... are regulated a breakthrough that could have a ... from Kent,s School of Biosciences uncovered the mechanism whereby ... known as actin filaments are ,fine-tuned, to ... filaments appear to completely stable, providing a framework for ...
(Date:7/29/2014)... that brings together two of the major disciplines behind ... insect fossils through stunning photographs and unique illustrations. , ... Jepson, details the incredible preservation and diversity of fossilised ... what these remarkable fossils can tell us about the ... our planet. Like the mosquito in Jurassic Park, many ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2
... The naked mole rat, a curiously strange, hairless rodent, ... Scientists at The University of Texas Health Science Center San ... explore this mystery. On May 2 a Barshop Institute ... protein disposal called proteasome assemblies differ in composition ...
... UPTON, NY Hydrogen gas offers one of ... fuels. But traditional methods of producing pure hydrogen face ... releasing harmful carbon dioxide into the atmosphere or requiring ... Now, scientists at the U.S. Department of Energy,s (DOE) ...
... announced today that it is a Grand Challenges Explorations winner, ... Dr. Gregor Reid and his team are the first ... The research project will study the impact of ... on the health outcomes of pregnant women and their children. ...
Cached Biology News:Scientists find differences in naked mole rat's protein disposers 2Low-cost nanosheet catalyst discovered to split hydrogen from water 2Low-cost nanosheet catalyst discovered to split hydrogen from water 3Low-cost nanosheet catalyst discovered to split hydrogen from water 4Lawson recieves Grand Challenges Explorations grant for groundbreaking research 2
(Date:7/30/2014)... 2014 Adding to their already extensive ... special – Buy 2 of any Weighing Boats ... benefit lab technicians looking for durable and reliable weighing ... for multiple applications including weighing liquids, solid, or granulated ... including diamond-shaped, hexagonal, square, aluminum weighing, and standard boats. ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... According to the new research report  "Digital ... Software), Delivery Modes (Web Based/Cloud Based) & Whole Slide ... published by MarketsandMarkets, analyzes and studies the major market ... North America , Europe , ... the World (RoW). Browse 78 market data ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3
... In a recent report that probably went unnoticed outside ... Managers released figures that show why the rest ... a hotbed for scientific research. The numbers demonstrate that ... in labs; it's about creating jobs for the 21st ...
... Madison, Wis. - CytoDyn , a New ... Bio-Manufacturing facility to manufacture its DNA-based, pre-flu vaccine. ... Waisman Center , the biomanufacturing facility is designed ... and II human clinical trials. CytoDyn hopes to have ...
... Area Technical College would like to see more women going ... of women in IT careers has declined from a high of ... MATC. And at MATC, enrollment of women in IT programs has ... in IT Expo at the college on Wednesday was Patricia ...
Cached Biology Technology:Tapping hidden assets: Wisconsin researchers who can create jobs 2Tapping hidden assets: Wisconsin researchers who can create jobs 3Tapping hidden assets: Wisconsin researchers who can create jobs 4MATC seeks to turn around falling tech enrollment among women 2
96 Well Plate Sterile, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... Console Orbital Shakers combine high durability ... programming power. The patented triple-counterbalanced ... unit to run with heavy out-of-balance ... system reduces contamination. The heavy ...
... orbital shakers combine high durability and capacity ... triple-counterbalanced heavy-duty mechanism prevents vibration, allowing the ... loads. Every other part, from the large ... thick machined aluminum platform is designed to ...
Biology Products: