Navigation Links
Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

f C-peptide, GADA and IA2 antibodies in Type 1 Diabetic Patients with Extreme Duration"]

Since 1970, Joslin Diabetes Center in Boston has awarded medals or certificates to people with type 1 diabetes who have been insulin-dependent continuously for at least 25 years. To date there have been approximately 2,400 50-Year Medals awarded and 17 distinctive 75-Year Medals. The Medalist Study began in April 2005 to identify physiological, clinical, genetic and other factors shared by the Medalists.

The study being presented at the ADA meeting is part of the second phase of the Joslin 50-Year Medalist Study that is assessing these factors in 326 patients with more than 50 years of insulin-dependent diabetes. It evaluated a subset of 125 people with type 1 diabetes for biomarkers of insulin function. Of this group, 12.7 percent had a c-peptide level greater than 0.3 ng/mL, which indicates active islet cells and some residual insulin production. Most of the Medalists have the characteristics associated with type 1 diabetes with or without the presence of c-peptide.

In addition, 23.2 percent of the c-peptide positive participants produced either of two antibodies, GADA and IA2, which attack islet cells. The study also found that 17 percent of participants who were not c-peptide positive produced GADA or IA2 antibodies to the islet cells, another indication that a small amount of islet cells may still be present and/or functioning.

"The findings are phenomenal," said Hillary Keenan, Ph.D., research associate at Joslin and co-investigator on the 50-Year Medalist Study, who will present the findings. "This is the first study to look at the specific biomarkers for islet cell presence in people with a 50-year duration of insulin-dependent diabetes." Other Joslin investigators in the study included Alessandro Doria, M.D., Ph.D., Lloyd Paul Aiello, M.D., Ph.D., Korey Hood, Ph.D., and Jennifer Sun, M.D.

The group also was tested for other cli
'"/>

Source:Joslin Diabetes Center


Page: 1 2 3

Related biology news :

1. Big hips, big belly? Its in your genes, Joslin-led study shows
2. UCSD team discovers specialized, rare heart stem cells in newborns
3. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
4. MIT chemist discovers secret behind natures medicines
5. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
6. Expedition discovers marine treasures
7. Team discovers possible universal strategy to combat addiction
8. Nobelist discovers antidepressant protein in mouse brain
9. Contrary to common wisdom, scientist discovers some mammals can smell objects under water
10. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
11. LSU professor discovers new species
Post Your Comments:
(Date:3/17/2015)... DIEGO , March 17, 2015 ... emotion analytics software, today announced general availability of ... web service for the analysis of facial expressions. ... experience advertising, media content, products and services. It ... attention, engagement and sentiment - as derived from ...
(Date:3/12/2015)... , March 12, 2015 IriTech, a leading ... member of the Texas Instruments Design Network, announced today ... has demonstrated its IriShield USB MK2120U device during a ... for pension distribution. The iris scanner ... be marketed in India through ...
(Date:3/12/2015)... MOUNTAIN VIEW, Calif. , March 12, 2015 ... EDTLOCATION:Online, with Complimentary Registration here: http://bit.ly/1G7Os0L . ... Program Manager Aravind SeshagiriPhoto - http://photos.prnewswire.com/prnh/20150311/181111 ... future in order to compete in several different ... the market is currently witnessing an uptrend. ...
Breaking Biology News(10 mins):New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3
... provides us with a rare glimpse into the softer side of ... shells but one of the most famous fossil locales in ... gills and eyes delicately preserved between the layers of dark rock. ... us a unique perspective on what life was like in the ...
... drugs are taken off the market and a major reason ... reporting the development of a new way to predict those ... which could save patients from severe side effects and save ... of Chemical Information and Modeling . Yoshihiro Yamanishi and ...
... from Lake Victoria are described by biologists ... and the Institute of Biology Leiden (Section Integrative Zoology) ... honour of Tijs Goldschmidt , author of Darwin,s ... dramatic extinction of hundreds of cichlid species in Lake Victoria ...
Cached Biology News:A new fish species from Lake Victoria named in honor of the author of Darwin's Dreampond 2
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... March 26, 2015 Agnition announced today ... of American Farmer, airing for the first time at ... of American Farmer will explore the extremely important role ... producers with a patented Microbial Catalyst™ technology that enhances ... yields. The segment will air again on April 28. ...
(Date:3/25/2015)... The surging prevalence of internet use ... media growth, with over 50% of the world’s ... Insurance companies are making use of social media ... a diversity of their services and products. , ... networking services as part of sales and marketing, ...
(Date:3/25/2015)... -- Accelovance, a therapeutically focused contract research organization (CRO), ... Organization" at the upcoming Vaccine Industry Excellence (ViE) Awards ... This is the eighth consecutive year Accelovance has been ... "Best Contract Research Organization" in 2009, 2010, and 2011, ... "We,re excited to be a finalist for the ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... a high-technology spin-off of the University of Wisconsin-Madison, recorded ... biggest blackout the nation has ever seen. In a ... were recorded in New York and Michigan at approximately ... northeastern United States, with the I-Grid recording over 200 ...
... is experiencing problems with the SoBIG.F e-mail virus ... spread. This virus and others, which have ravaged computers ... has affected the e-mail operations for all users. UW-Madison ... at the height of the virus problem. , ,The ...
... problem , ,Madison, WI- Over 2,200 computers on the ... virus last week. At the same time, it was revealed ... the recipient of a continuous large scale flood of inbound ... Time Protocol (NTP) servers. NTP servers are used to synchronize ...
Cached Biology Technology:Local Company Records Blackout with Web-Based Monitoring System 2Local Company Records Blackout with Web-Based Monitoring System 3UW-Madison Battles Prolific Computer Virus 2Flawed Routers Flood UW Server 2Flawed Routers Flood UW Server 3
...
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
BD BioCoat Laminin 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
Biology Products: