Navigation Links
Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

f C-peptide, GADA and IA2 antibodies in Type 1 Diabetic Patients with Extreme Duration"]

Since 1970, Joslin Diabetes Center in Boston has awarded medals or certificates to people with type 1 diabetes who have been insulin-dependent continuously for at least 25 years. To date there have been approximately 2,400 50-Year Medals awarded and 17 distinctive 75-Year Medals. The Medalist Study began in April 2005 to identify physiological, clinical, genetic and other factors shared by the Medalists.

The study being presented at the ADA meeting is part of the second phase of the Joslin 50-Year Medalist Study that is assessing these factors in 326 patients with more than 50 years of insulin-dependent diabetes. It evaluated a subset of 125 people with type 1 diabetes for biomarkers of insulin function. Of this group, 12.7 percent had a c-peptide level greater than 0.3 ng/mL, which indicates active islet cells and some residual insulin production. Most of the Medalists have the characteristics associated with type 1 diabetes with or without the presence of c-peptide.

In addition, 23.2 percent of the c-peptide positive participants produced either of two antibodies, GADA and IA2, which attack islet cells. The study also found that 17 percent of participants who were not c-peptide positive produced GADA or IA2 antibodies to the islet cells, another indication that a small amount of islet cells may still be present and/or functioning.

"The findings are phenomenal," said Hillary Keenan, Ph.D., research associate at Joslin and co-investigator on the 50-Year Medalist Study, who will present the findings. "This is the first study to look at the specific biomarkers for islet cell presence in people with a 50-year duration of insulin-dependent diabetes." Other Joslin investigators in the study included Alessandro Doria, M.D., Ph.D., Lloyd Paul Aiello, M.D., Ph.D., Korey Hood, Ph.D., and Jennifer Sun, M.D.

The group also was tested for other cli
'"/>

Source:Joslin Diabetes Center


Page: 1 2 3

Related biology news :

1. Big hips, big belly? Its in your genes, Joslin-led study shows
2. UCSD team discovers specialized, rare heart stem cells in newborns
3. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
4. MIT chemist discovers secret behind natures medicines
5. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
6. Expedition discovers marine treasures
7. Team discovers possible universal strategy to combat addiction
8. Nobelist discovers antidepressant protein in mouse brain
9. Contrary to common wisdom, scientist discovers some mammals can smell objects under water
10. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
11. LSU professor discovers new species
Post Your Comments:
(Date:9/30/2014)... -- Winners of The Economist,s prestigious Innovation awards 2014 ... place at the JW Marriott Hong Kong on Friday, October 10 ... their experiences and the lessons those hold for others. The awards, ... the past decade, will be presented at a ceremony in ... will be the first time the ceremony has come to ...
(Date:9/29/2014)... tar tended to be lower for smokers of slim ... nicotine tended to be lower. , Slim cigarettes are ... around the world. Previous studies have shown that the ... these cigarettes are lower than those in regular cigarettes. ... are not necessarily linked to a reduced exposure to ...
(Date:9/29/2014)... Between 1970 and 2010 populations of mammals, birds, ... 52 percent, says the 2014 Living Planet Report ... biodiversity loss occurs disproportionately in low-income countriesand correlates ... , In addition to the precipitous decline in ... warning signs about the overall health of the ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Slim cigarette smokers not exposed to more harmful chemicals 2Half of global wildlife lost, says new WWF report 2
... another accident as catastrophic as the Deepwater Horizon explosion ... Academy of Engineering and National Research Council says, companies ... approach to anticipating and managing possible dangers at every ... wells to designing blowout preventers that function "under all ...
... model to investigate allergy to fenugreek has been developed by ... cross-reactivity to peanut, soy and lupin, major food allergens with ... the legume family and is used as an ingredient in ... severe yet its presence is rarely declared in ingredient listings. ...
... People and giant snakes not only target each other for ... to a study co-authored by a Cornell University researcher. , ... Filipino hunter-gatherer group have been attacked by giant pythons ... next meal. The study also finds that both the hunters ...
Cached Biology News:Industry, regulators should take 'system safety' approach to offshore drilling in aftermath of Deepwater Horizon accident, says new report 2Industry, regulators should take 'system safety' approach to offshore drilling in aftermath of Deepwater Horizon accident, says new report 3New food allergy model for fenugreek developed 2
(Date:9/30/2014)... Windsor, CT (PRWEB) September 30, 2014 ... distributor of scientific research products, recently opened an ... its comprehensive cell culture product lines developed and ... through its online store include Biological Industries’ Nutristem® ... (hMSC) and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 30, 2014 UFP Technologies, a ... packaging has recently introduced a custom insulated shipping ... . The new insulated shipper solves the issue ... process. UFP Technologies’ BioShell is a universal storage ... storage, handling and shipping. The insulated shipper keeps ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Back in the ... 500 square feet. per employee, which included space for circulation ... then.” says Jeff Howell, partner at Nidea Corporate Real ... in Toronto. “By the year 2000, however, 250 square ... seeing that number come down to 175 to 225 square ...
(Date:9/29/2014)... (PRWEB) September 30, 2014 Each ... burn injuries require medical attention. In the military, ... serious complications to battlefield medical care. More than ... and Afghanistan. Burn wounds heal slowly, remain inflamed ... be excessive, physically debilitating and functionally damaging. While ...
Breaking Biology Technology:Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Faster Healing with Fewer Scars 2
... November 30 NOLabs AB, the Swedish,medtech ... on the NitroSense(R) Technology, today reported that ... development of a new line of,products for ... Methicillin,Resistant Staphylococcus aureus, a bacterium that is ...
... -- A water repellent developed by researchers at the ... at its best and could open a floodgate of ... by John Simpson, is easy to fabricate and uses ... the creation of a new class of water repellant ...
... Inc. (NASDAQ: CALP ) today announced that ... Day at The Hilton Boston,Financial District Hotel on ... Caliper, will participate in a day of one-on-one ... however a copy of,the Corporate Presentation, which will ...
Cached Biology Technology:NOLabs AB Achieves Break-Through in Fight Against MRSA-Bacteria 2ORNL super water repellent could cause big wave in market 2
The filter 530DF28 for the Molecular Imager FX is a band pass filter for ECL Plus, AttoPhos, SYBR Green, Alexa Fluor 488, FITC, Cy2, and Pro-Q Emerald dyes....
... Model 175 tube gel cell is a ... for 2-D electrophoresis applications. The upper buffer ... tubes 9-23 cm long for isoelectric focusing ... buffer chamber and cooling core, lower buffer ...
... ApopTag Fluorescein Direct In Situ ... cells in situ by the ... fragments are tagged with a ... kit provides fluorescence staining for ...
... is a highly advanced digital imaging ... imaging and automation technology that is ... archving/retrieval and colored professional reporting. The ... fastest scanning and detection modules for ...
Biology Products: