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Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

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The group subsequently showed in laboratory studies that in mouse mammary cells lacking caveolin and certain growth-stimulating factors, estrogen receptors were again increased, leading them to conclude that two factors may be required for estrogen receptor upregulation: Caveolin gene inactivation and growth factor depletion.

The findings may have clinical implications. According to Dr. Lisanti, those breast cancer patients who are estrogen receptor-positive and who have caveolin mutations are much more likely to have a cancer recur than are such individuals who don't carry caveolin gene mutations. "It's a risk factor," he notes.


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Source:Thomas Jefferson University


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