Navigation Links
Jefferson scientists find high glucose before surgery raises risk of dangerous complications

Patients who have high blood sugar before undergoing surgery run an increased risk of developing blood clots, deep vein thrombosis and even pulmonary embolism after surgery.

Boris Mraovic, M.D., assistant professor of anesthesiology in the Artificial Pancreas Center at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his colleagues examined records of nearly 6,500 hip or knee replacement surgery patients at Thomas Jefferson University Hospital who were admitted between 2003 and 2005. They asked what happened to patients with high blood sugar that wasn't well controlled prior to surgery.

Of these patients, 38 had very high blood glucose ?more than 250 mg/dl ?on the day of preoperative testing and the day of surgery. The team found that approximately 10.5 percent of the patients with high blood sugar developed a pulmonary embolism, a life-threatening condition in which blood clots travel to the lungs, after surgery, a rate that is 6.2 times greater than would be expected in the general population. The researchers report their results on October 15, 2006 at the annual meeting of the American Society of Anesthesiologists in Chicago.

"These data suggest that if an individual has high blood glucose and is coming for surgery, he or she should correct it first and probably postpone the surgery," says Dr. Mraovic.

Physicians should also be aware of these risks, he notes, and should make it a priority to be sure that patient glucose levels are under control prior to and during surgery.

Dr. Mraovic says that as many as 25 percent of all surgery patients come to the hospital with high blood sugar. Another 10 percent have raised levels due to pre-surgery stress. Deep vein thrombosis occurs in approximately two million Americans each year. Pulmonary embolism (PE), which can cause sudden death, occurs when a clot dislodges from the vein and circulates into the lungs. Each year some 600,000 patients develop PE , which causes or contributes to as many as 200,000 deaths annually in the U.S.

He notes that recent studies have begun to show connections between increased blood sugar and a greater risk of dying or of medical complications for hospital patients in intensive care or cardiac care units. Tightening glucose control dramatically cuts those risks, as well as reduces hospital stays.

Because the current study was retrospective, Dr. Mraovic says, drawing firm conclusions from the results can be difficult. The findings need to be confirmed in a randomized, prospective trial.

He would like to next find out whether controlling blood sugar before and during surgery could actually result in a lower risk of blood clots and pulmonary embolism. He also would like to explore some of the potential physiological mechanisms related to increased blood glucose and blood clotting.


'"/>

Source:Thomas Jefferson University


Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson researchers uncover new way nature turns genes on and off
9. Jefferson scientists find aging gene also protects against prostate cancer development
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/14/2016)... AVIV, Israel , April 14, 2016 ... Behavioral Authentication and Malware Detection, today announced the appointment ... already assumed the new role. Goldwerger,s leadership ... BioCatch, on the heels of the deployment of its ... addition, BioCatch,s behavioral biometric technology, which discerns unique cognitive ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... Amgen, will join the faculty of the University of North Carolina Kenan-Flagler ... of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: