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Jefferson scientists find aging gene also protects against prostate cancer development

e frequently an indication of prostate cancer growth or recurrence, whereas falling levels indicate tumor shrinkage.

“This study shows that there is potentially new opportunity for these cancer patients with drugs that regulate SIRT1,?Dr. Pestell says.

“The discovery is a true breakthrough in our field,?says Chawnshang Chang, Ph.D., George Hoyt Whipple Professor of Pathology and Laboratory Medicine and professor of urology and of biochemistry at the University of Rochester.

Dr. Pestell and his co-workers also found a single amino acid within the androgen receptor that reacts with SIRT1’s enzymatic activity and proved in the laboratory that it was key to its cancer-halting effect. The work could lead to a model for drug screening, Dr. Pestell notes.


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Source:Thomas Jefferson University


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