Navigation Links
Jefferson researchers uncover new way nature turns genes on and off

nstead can repress Ubx activity by blocking its activity in certain types of cells in the developing embryo.

"Importantly, non-coding RNAs are very tightly developmentally regulated, as we show in case of bxd RNAs," Dr. Mazo notes. "These create an enormous potential to regulate the neighboring coding genes in a time- and tissue-specific manner. This is a new type of transcriptional regulation mechanism for higher eukaryotes, and it is very likely that it is conserved in mammals."

Understanding the details of the TrxG system could someday have implications for ALL, a dangerous type of childhood leukemia. The disease stems from gene rearrangements in utero. MLL, the gene that is affected in humans, corresponds to Trithorax in fruit flies. "ALL is thought to be a disease of misregulated HOX genes," says Dr. Mazo.

HOX gene groups have long been known to be "transcriptional regulators" that control the multitude of genes involved in embryonic development, Dr. Mazo says. He and his group would like to ultimately better understand the early stages of such development.


'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson scientists find aging gene also protects against prostate cancer development
9. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jefferson researchers uncover new way nature turns genes and off

(Date:7/28/2014)... 100 drugs already approved by the U.S. Food and ... the growth of certain bacterial pathogens inside human cells, ... spotted fever. The findings, published in mBio , ... Microbiology, demonstrate a new way of identifying non-antibiotic drugs ... , A handful of drugs on the list inhibit ...
(Date:7/28/2014)... reached the South Pole in 1911, but new research ... human. , Using data from 16 ice cores collected ... the South Pole, a group led by Joe McConnell ... created the most accurate and precise reconstruction to date ... record, described in an article published today in the ...
(Date:7/28/2014)... in the United States have a circulatory problem of ... painful and may even require surgery in serious cases. ... and, in turn, limb amputation. , At The University ... School, scientists tested a non-surgical preventative treatment in a ... with increased blood circulation. Their proof-of-concept study appears ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... American Academy of Pediatrics National Children,s Art Contest drew hundreds ... With the theme of "My Healthy Lifestyle," the 2011 ... obesity, diet, exercise, sleep and limiting screen time. This was ... of the three age groups each receive a $500 cash ...
... grown apple may hold within it a tiny bit of ... teamed up on a startup that promises to turn slash ... for farmers that helps their soil hold water and nutrients. ... for farmers. "Wine growers, organic farmers and gardeners of all ...
... generally considered to be a good thing for people ... too risky for women who are also pregnant. Some ... the risk of women developing preeclampsia, a condition that ... this might happen has remained unknown. New research using ...
Cached Biology News:Turning slash piles into soil benefit 2Exercise before and during early pregnancy increases two beneficial proteins for mothers-to-be 2
(Date:7/29/2014)... 2014 DisasterTalk is a texting app which ... phone masts or other transmitters are down. The app can ... without the need for any Wi-Fi, and can also use ... new app has launched as a housing report ... high risk of being affected by natural disasters. With the ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 G-CON Manufacturing ... modular cleanrooms, today announced a new leadership appointment designed ... United States and abroad. , Maik Jornitz, Chief ... the company’s President charged with leading the pioneering company ... we enter this stage of development and look forward ...
(Date:7/29/2014)... The prestigious "Discovery or Exploration in ... awarded to Juliana Hillis and Kaylie O’Connell, students at ... “From an Egg, Everything: America’s First IVF Baby". This ... the National History Day program during a week-long final ... in Washington, D.C. , The growing popularity of the ...
(Date:7/29/2014)... Acres, FL (PRWEB) July 29, 2014 ... ex situ lift out specimen preparation solutions, has been ... Trademark Office for specimen manipulation methods incorporating a unique ... 8,740,209. This is the second company patent for ... A. Giannuzzi. , These complementary patents extend ...
Breaking Biology Technology:DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2
... like when it was a baby. They know what it ... looked in its youth. Thanks to technological advances, however, scientists ... of how the cosmos developed into the kind of place ... They plan to gather these never-before-obtained insights with a potentially ...
... BOTHELL, Wash., June 30, 2011 SCOLR Pharma, Inc. ... second and final tranche of its previously-announced private placement ... (the "Debentures").  The Company raised a total of $1,190,200 ... net proceeds for working capital and other general corporate ...
... OXIS International, Inc. (OTC Bulletin Board: OXIS ; ... Saloff to its Board of Directors.  The Company,s Board now ... are very pleased to have David Saloff, an outstanding businessmen ... said Anthony J. Cataldo, Chairman of OXIS International. "OXIS is ...
Cached Biology Technology:Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 2Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 3Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 4SCOLR Pharma, Inc. Announces Final Closing of Private Placement 2SCOLR Pharma, Inc. Announces Final Closing of Private Placement 3OXIS International Names Healthcare Industry Entrepreneur David Saloff to Board of Directors 2OXIS International Names Healthcare Industry Entrepreneur David Saloff to Board of Directors 3