Navigation Links
Jefferson researchers uncover new way nature turns genes on and off

Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. If they're right, and the same processes are at work in higher organisms, including mammals, the findings could eventually have implications for improving the understanding of a range of diseases, including childhood cancer.

Reporting in the journal Cell, Alexander Mazo, Ph.D., professor of biochemistry and molecular biology at Jefferson Medical College, Svetlana Petruk, Ph.D., and their co-authors focused on pieces of genetic material called non-coding (nc)RNAs. About two-thirds of the human genome is converted into such RNAs (the better known messenger RNAs are translated into proteins), though the function of the majority is unknown. The researchers detailed a possible mechanism by which ncRNAs briefly control the functioning of homeotic, or HOX, genes, which guide the master developmental plan of the organism.

"We think that this new mechanism operates early in embryogenesis," says Dr. Mazo.

According to Dr. Mazo, the researchers found that one of the likely mechanisms behind ncRNAs' ability to regulate essential coding genes is through a "transcription interference" mechanism. "Such mechanisms are known in bacteria and yeast, but not much is known in higher organisms," he explains.

In the fruit fly, HOX gene activity is maintained by genes and proteins in the Trithorax group (TrxG). These proteins are thought to act through so-called maintenance elements, one of which, in a nearby region, bxd, is located between two HOX genes, Ubx and abd-A. Dr. Mazo explains that several "long" ncRNAs are transcribed through bxd maintenance elements. They were thought to be expressed in the same cells as Ubx, and to regulate HOX gene coding sequence expression. But the researchers found something different: ncRNAs i
'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson scientists find aging gene also protects against prostate cancer development
9. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jefferson researchers uncover new way nature turns genes and off

(Date:1/22/2015)... 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics ... its new website design. "When we launched FindBiometrics ... Peter O,Neill , founder and CEO of FindBiometrics. "Now ... involvement from the key players on a very broad scale.  ...
(Date:1/22/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the recent success of the Wocket™ smart wallet at CES 2015 ... wallet was named as one of the "11 Hot Products at CES" ... Launched At CES So Far" by Newseveryday.com and "The top 10 gadgets ...
(Date:1/22/2015)... YORK , Jan. 22, 2015   EyeLock, Inc. , ... it has appointed Steve Gerber to the new ... will be responsible for leading development of mobile platforms and ... years of success and innovation in the semiconductor industry to ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... scientists believe an Oregon State University graduate student ... Pacific Southwest Research station on the Tahoe National ... presence has not been confirmed in California since ... was conducting research on another carnivore called the ...
... Friday, March 7, 2008) New research from ... American diet of eating lots of meat and not much ... pose a risk to infant neurological development. Omega-3 fatty acids ... and herring and in smaller amounts in eggs and chicken. ...
... - A newly defined biochemical pathway in plants may ... yield larger quantities of alternative transportation fuels than currently ... The pathway moves materials that determine cell shape and ... Szymanski, a plant geneticist and cellular biologist. By learning ...
Cached Biology News:Scientists believe photograph depicts wolverine in California 2Typical North American diet is deficient in omega-3 fatty acids 2Newly defined signaling pathway could mean better biofuel sources 2Newly defined signaling pathway could mean better biofuel sources 3Newly defined signaling pathway could mean better biofuel sources 4
(Date:1/22/2015)... (PRWEB) January 22, 2015 GEA Niro ... table top laboratory homogenizer, the PandaPLUS 2000, which is ... nanoemulsions , and cell disruption . This compact ... products, fruit juices, liquid food, food additives and ingredients ...
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
(Date:1/22/2015)... Geneva, Switzerland (PRWEB) January 22, 2015 ... for characterized mammalian Research Cell Banks (RCBs) used for ... generated Research Cell Banks will include Next-Generation Sequencing ... cell’s genetic architecture de-risks biologic manufacturing by ensuring the ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... biometrics company enabling applications for the real ... with Methode Electronics, Inc. One of the ... being a solid Tier 1 automotive supplier ... devices. Together, Methode and Lumidigm will bring ...
... ... alternatives, WALTHAM, Mass., Aug. 5 ... Company is focusing its,day-to-day operations exclusively on obtaining financing or consummating ... Company,s employees were released from employment, except,for Shawn Cain, the Company,s ...
... to Curb Unsafe Sex and Drug, Use ... Response, MEXICO CITY, Aug. 5 In a ... calls on global leaders to aggressively,expand HIV prevention programs ... use. Citing hundreds of clinical trials and,observational studies, the ...
Cached Biology Technology: Lumidigm Signs Strategic Agreement with Methode Electronics : Automotive Supplier Invests in Biometric Component Development 2Arbios Announces It Has Suspended Operations 2Arbios Announces It Has Suspended Operations 3Arbios Announces It Has Suspended Operations 4Arbios Announces It Has Suspended Operations 5Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 2Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 3Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 4
Geneticin Selective Antibiotic liquid...
Immunogen: Extract of pigmented melanoma metastases from lymph nodes. Storage: -20 C, Avoid Freeze/Thaw Cycles...
alpha N-catenin (C-19)...
... Clone/PAD: ZMD.257. Immunogen: Synthetic peptide ... the human Connexin 36 protein This ... used to generate another Zymed polyclonal Connexin ... Reacts with mouse Connexin 36. Reactivity: ...
Biology Products: