Navigation Links
Jefferson researchers uncover new way nature turns genes on and off

Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. If they're right, and the same processes are at work in higher organisms, including mammals, the findings could eventually have implications for improving the understanding of a range of diseases, including childhood cancer.

Reporting in the journal Cell, Alexander Mazo, Ph.D., professor of biochemistry and molecular biology at Jefferson Medical College, Svetlana Petruk, Ph.D., and their co-authors focused on pieces of genetic material called non-coding (nc)RNAs. About two-thirds of the human genome is converted into such RNAs (the better known messenger RNAs are translated into proteins), though the function of the majority is unknown. The researchers detailed a possible mechanism by which ncRNAs briefly control the functioning of homeotic, or HOX, genes, which guide the master developmental plan of the organism.

"We think that this new mechanism operates early in embryogenesis," says Dr. Mazo.

According to Dr. Mazo, the researchers found that one of the likely mechanisms behind ncRNAs' ability to regulate essential coding genes is through a "transcription interference" mechanism. "Such mechanisms are known in bacteria and yeast, but not much is known in higher organisms," he explains.

In the fruit fly, HOX gene activity is maintained by genes and proteins in the Trithorax group (TrxG). These proteins are thought to act through so-called maintenance elements, one of which, in a nearby region, bxd, is located between two HOX genes, Ubx and abd-A. Dr. Mazo explains that several "long" ncRNAs are transcribed through bxd maintenance elements. They were thought to be expressed in the same cells as Ubx, and to regulate HOX gene coding sequence expression. But the researchers found something different: ncRNAs i
'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson scientists find aging gene also protects against prostate cancer development
9. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jefferson researchers uncover new way nature turns genes and off

(Date:3/31/2015)... , March 31, 2015   Guidepoint , ... launch of the Post-Surgical Pain Management TRACKER, part of ... tracking usage trends in the medical device and therapeutics ... to data including treatment volumes, market share, and adoption ... pain associated with joint surgery. The Post-Surgical ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced ... Strategic Business Report" report to their offering. This ... US$ Thousands by the following Segments: Face Biometrics, and Voice Biometrics. ... Canada , Japan , Europe ... & Africa , and ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... found at Dinosaur Cove in Victoria, Australia, were likely ... the oldest known bird tracks in Australia. The ... the footprints led by Anthony Martin, a paleontologist at ... which include tracks, burrows and nests. The study was ...
... sandpipers ( Calidris pusilla ) feeding during low tide ... Beauchamp, an ornithologist and research officer at the University ... the periphery remained alert and used short pecks to ... the group relaxed their vigilance and fed on a ...
... This news release is available in French ... activity during a cognitive task even in some people who are ... University of Montreal and Boston,s Brigham and Women,s Hospital. The findings ... how quickly light impacts on cognition. "We were stunned to discover ...
Cached Biology News:Tell-tale toes point to oldest-known fossil bird tracks from Australia 2Tell-tale toes point to oldest-known fossil bird tracks from Australia 3Bird buffet requires surveillance 2Study with totally blind people shows how light helps activate the brain 2
(Date:5/4/2015)... --  Intrexon Corporation (NYSE: XON ) today ... after the market closes on May 11, 2015.  The ... 5:30 PM ET to discuss the results and provide ... may be accessed by dialing 1-888-346-3959 (Domestic US) and ... Call."  Participants may also access the live webcast through ...
(Date:5/1/2015)... - BioAmber Inc. (NYSE: BIOA ), an industrial ... priced an underwritten registered offering of 3,900,000 shares of ... share, and granted the underwriters in the offering a ... shares of its common stock. The gross proceeds to ... to close on May 6, 2015, subject to customary ...
(Date:5/1/2015)... ALBANY, N.Y. , May 1, 2015 ... today that William S. Marth , AMRI,s President ... of America Merrill Lynch 2015 Health Care Conference on ... A live audio webcast of the presentation can ... http://ir.amriglobal.com/events.cfm?CalendarID=2          The webcast will be ...
(Date:4/30/2015)... , April 30, 2015   Tamir Biotechnology , ... an update on its Ebola antiviral therapy program. ... candidates, TMR004, is currently being evaluated and considered by ... battle against Ebola. During the first quarter of 2015, ... Meeting To Accelerate The Evaluation of Potential Treatments and ...
Breaking Biology Technology:Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 3AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4
... Better Option for Humans, EGG HARBOR TOWNSHIP, ... first time, The British Institute of Homeopathy, U.S.A. ... U.S. medical and,homeopathic practitioners for a low-introductory cost ... therapy is more advantageous because,it does not carry ...
... Inc. (Nasdaq and SWX: BMRN) announced today the ... Research. Former Vice President of,Research and Development for ... biotechnology patents and the recipient of a,collection of ... Year Awards from Intellectual Property Owners, Inc., ...
... (Nasdaq: KNDL ), a,leading, global full-service clinical ... Officer Candace Kendle, PharmD,will participate in the Wachovia ... the Langham Hotel in Boston, Jan. 29-31, 2008. ... 1:30 p.m. Eastern Time., (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ...
Cached Biology Technology:BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 2BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 3Kendle to Present at the Wachovia 2008 Healthcare Conference 2
... PCR System is the only PCR system ... and every time. It provides accuracy, consistency, ... source or the property of the DNA ... Enzyme Mix, a unique blend of thermostable ...
ID clarifier: With ethidium bromide (50 μg/ml)...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... Buffer is a convenient, premixed, ... samples and Perfect RNA Markers. ... no dilution and is suitable ... Simply mix equal volumes of ...
Biology Products: